A5043151692- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Sexual Differentiation and Disorders
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Allergic Rhinitis and Sensitization
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Urological Disorders and Treatments
- Adrenal Hormones and Disorders
- Childhood Cancer Survivors' Quality of Life
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Mobile Health and mHealth Applications
- Diabetes Treatment and Management
- Child Nutrition and Feeding Issues
- Reproductive Biology and Fertility
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Celiac Disease Research and Management
- Clostridium difficile and Clostridium perfringens research
Tel Aviv University
2014-2024
Assaf Harofeh Medical Center
2015-2024
University of Washington Medical Center
2019
Shaare Zedek Medical Center
2018
Bikur Cholim Hospital
2018
Hebrew University of Jerusalem
2018
Hospital for Sick Children
2005-2013
Zero to Three
2011
In-Q-Tel
2011
Pediatrics and Genetics
2007
The causes of ovarian dysgenesis remain incompletely understood. Two sisters with XX carried compound heterozygous truncating mutations in the BRCA2 gene that led to reduced protein levels and an impaired response DNA damage, which resulted chromosomal breakage failure RAD51 be recruited double-stranded breaks. also had microcephaly, one sister was long-term remission from leukemia, been diagnosed when she 5 years old. Drosophila mutants were null for orthologue sterile, gonadal present both...
OBJECTIVE Previous studies have demonstrated an association between gut microbiota composition and type 1 diabetes (T1D) pathogenesis. However, little is known about the function of microbiome in adults with longstanding T1D or its host glycemic control. RESEARCH DESIGN AND METHODS We performed a metagenomic analysis obtained from fecal samples 74 T1D, 14.6 ± 9.6 years following diagnosis, compared their microbial to 296 age-matched healthy control subjects (1:4 ratio). further analyzed taxa...
Billions of people have been under lockdown in an attempt to prevent COVID-19 spread. Lifestyle changes during could lead deterioration glycemic control type 1 diabetes (T1D). We aimed assess the impact on pediatric patients with T1D.This observational real-life study from AWeSoMe Group assessed continuous glucose monitoring (CGM) metrics 102 T1D (52.9% males, mean age 11.2 ± 3.8 years, duration 4.2 years) who used Dexcom G5. The data were accessed without any interface between patients,...
Objective To evaluate the incidence and severity of ketoacidosis (DKA) at type 1 diabetes diagnosis during first wave coronavirus disease 2019 (COVID-19) pandemic in Israel. Research Design Methods A population-based study product a national collaboration Israeli pediatric centers investigated presentation childhood-onset diabetes. The frequencies DKA severe observed COVID-19 period from March 15, 2020 (commencement nationwide lockdown) until June 30, were compared with same periods 2019,...
OBJECTIVE Despite technological advances, results from various clinical trials have repeatedly shown that many individuals with type 1 diabetes (T1D) do not achieve their glycemic goals. One of the major challenges in disease management is administration an accurate amount insulin for each meal will match expected postprandial response (PPGR). The objective this study was to develop a prediction model PPGR T1D. RESEARCH DESIGN AND METHODS We recruited T1D who were using continuous glucose...
Background and Aims: Achieving good glycemic control is a major challenge for adolescents with type 1 diabetes (TID). The introduction of the MiniMed 780G system, an advanced hybrid closed-loop (AHCL) that enables automatic correction insulin, gave hope improved outcomes in adolescents. We assessed specific characteristics associated measures youth T1D switching to Minimed 780G. Methods: This retrospective observational real-life multicenter study from AWeSoMe Group continuous glucose...
Background Moulds are ubiquitous indoor as well outdoor allergens and therefore potential candidates for environmental control measures. However, very few studies have been performed to examine the significance of moulds in allergic diseases effectiveness measures reduce quantity has not established. Objective To determine contribution manifestations. Methods Prevalence rhinitis asthma 395 members a rural community were examined by questionnaire examination medical files. The atopic status...
The 34th annual meeting of the International Society for Pediatric and Adolescent Diabetes (ISPAD), held in Durban, South Africa, was entitled ‘Advancing Care’ aimed at reflecting need continuous improvement care world’s children with diabetes. In his opening remarks, conference president Dr Kuben Pillay defined magnitude problem diabetes world today: currently, there are 440 000 aged 0–14 yr type 1 mellitus (T1DM) all over a 3% increase estimated number 70 newly diagnosed cases per year...
Intentional insulin omission is a unique inappropriate compensatory behavior that occurs in patients with type 1 diabetes mellitus, mostly females, who omit or restrict their required doses order to lose weight. Diagnosis of this underlying disorder difficult. We aimed use clinical and laboratory criteria create an algorithm assist the detection intentional omission.The distribution HbA1c levels from 287 (181 females) were used as reference. Data 26 analysed. The Weka (Waikato Environment...
Background and objectives Alpha-1 antitrypsin (AAT) has been shown to reduce pro-inflammatory markers protect pancreatic islets from autoimmune responses in recent studies. Our aim was evaluate its safety tolerability three different doses, a pediatric population with onset type 1 diabetes mellitus (T1DM). Methods A 37-wk prospective, open-label, phase I/II interventional trial, comprised of 24 recently diagnosed subjects (12 males; age 12.9 ± 2.4 yr), who received 18 infusions 40, 60, or 80...
Children with chronic diseases were unable to receive their usual care during COVID-19 lockdown. We assessed the feasibility and impact of telehealth visits on time-in-range (TIR) paediatric individuals type 1 diabetes (T1D). An observational multicentre real-life study. Patients scheduled for an in-clinic visit lockdown offered participate in a visit. Sociodemographic, clinical, continuous glucose monitor pump data recorded 2 weeks prior after The primary endpoint was change relative-TIR,...
Background Prevalence of youth-onset type 2 diabetes (T2D) has increased worldwide, paralleling the rise in pediatric obesity. Occurrence and clinical manifestations vary regionally demographically. Objectives We assessed incidence, demographic T2D Israel. Methods In a national observational study, demographic, clinical, laboratory data were collected from medical records children adolescents, aged 10–18 years, diagnosed with between years 2008 2019. Results The incidence Israel...
Abstract Background The effect of the amount transient cow's milk formula (CMF) consumed during first days life on IgE‐cow's allergy (IgE‐CMA) is unknown. Methods A cohort 58 patients with IgE‐CMA was identified from a large scale population‐based study 13,019 infants followed birth. group 116 matched for sex and breastfeeding only duration (beyond nursery period), another random 259 healthy were used as controls. Parents interviewed infants' medical records searched to assess CMF...