The effect of oral administration vanadate, in normalizing blood glucose levels streptozotocintreated rats (ST-rats), is further characterized and its mode action determined.We have examined the effects two orally administered doses sodium metavanadate.High concentrations vanadate (0.8 mg/ml drinking water) reduced within 2-4 days application led to appearance hypoglycemia test animals.Lower (0.2 also lowered 4 days, but did not lead for at least 3 weeks.These were found be reversible;...

<i>Background:</i> Previous reports have shown an association between inflammatory diseases such as systemic lupus erythematosus or rheumatoid arthritis and the metabolic syndrome. Recent data demonstrate that psoriasis is disease, suggesting may be one of components <i>Objective:</i> To assess <i>Methods:</i> A cross-sectional study was performed utilizing database Clalit Health Services. Case patients were defined with a diagnosis vulgaris. Controls...

Background: Subclinical thyroid disease is common; however, screening recommendations using serum thyrotropin (TSH) level determinations are controversial.Methods: To study the use of TSH by primary care physicians and define populations at risk for having an abnormal follow-up, based on initial levels, we conducted observational a large health database in setting management organization.All outpatients without or pregnancy taking medication that may alter function whom was measured 2002...

We have studied the effects of oral administration vanadate, an insulinometic agent and a potent inhibitor phosphotyrosyl protein phosphatase (PTPase) in vitro, on blood glucose PTPase action, two hyperinsulinemic rodent models non-insulin-dependent diabetes mellitus (NIDDM). Oral vanadate (0.25 mg/ml drinking water) to ob/ob mice for 3 wk lowered level from 236 +/- 4 143 2 mg/dl without effect body weight. Administration db/db produced similar effect. Electron microscopic examination...

Abstract Background Previous reports have shown an association between psoriasis and the metabolic syndrome, but there are only a few studies on diabetes. Objectives To study Methods A cross‐sectional was performed utilizing database of Clalit Health Services (CHS). Patients who were diagnosed with compared CHS enrolees without regarding prevalence diabetes identified using chronic diseases registry. Chi‐squared tests used to compare categorical parameters. Logistic regression models for...

Because clinical manifestations of thyroid disorders are variable and subtle in children adolescents, function tests often repeated patients with nonspecific symptoms.The objective the study was to determine natural history initial abnormal TSH define populations at greater risk for developing a subsequent dysfunction.A total 121,052 1.043 million outpatients aged 0.5-16 yr insured by Clalit Health Medical Organization had determination 2002 follow-up 2007. Extracted from database were their...

To examine the role of parenting style in achieving metabolic control and treatment adherence adolescents with type 1 diabetes.Parents 100 diabetes completed assessments their sense helplessness. Parents patients rated patient to regimen. Glycemic was evaluated by HbA(1c) values.An authoritative paternal predicted better glycemic child; a permissive maternal poor adherence. A higher helplessness both parents worse lesser treatment. Parental significant predictor after correcting for other...

Summary Context Central precocious puberty ( CPP ), treated or untreated, may have implications in adulthood. Objective To assess the reproductive outcome and social adjustment of former women between 3rd 5th decades life. Design Cross‐sectional study an historical cohort. Methods Demographic data gynaecological history 214 aged 25–56 years [135 G n RH analogue a)‐treated, 18 cyproterone acetate C y A )‐treated, 61 untreated] 446 controls with normal puberty, matched for age year birth, were...

Central precocious puberty (CPP) may have clinical implications in adulthood. To assess the prevalence of obesity, metabolic outcome (hyperlipidemia, diabetes, and hypertension), malignancy rate former CPP women between third fifth decades life. This was a case control study historical cohort using computerized database health management organization. The setting Institute for Endocrinology Diabetes, Schneider Children's Medical Center Israel, Clalit Health Services. group comprised 142 aged...

Phosphotyrosine phosphatase (PTPase) activity in rat liver was measured using a phosphopeptide substrate containing sequence identity to the major site of insulin receptor autophosphorylation. PTPase detected both cytosolic and particulate fractions produced linear dephosphorylation over 15-min time course. In rats made insulin-deficient diabetic by streptozotocin treatment (STZ), increased 180% control values after 2 d diabetes remained elevated at 30 (P less than 0.02). Gel filtration on...

Inflammatory bowel disease (IBD) patients undergo multiple radiological evaluations.To estimate total and abdominal radiation exposure from diagnostic X-ray investigations in IBD the associated risk factors.Patients with Crohn's (CD) or ulcerative colitis (UC) treated clinic were recruited. Clinical data extracted patient files obtained central HMO computer base.A of 199 CD 125 UC included. The mean cumulative estimated doses (CED) for 21.1 19.5 15.1 20.4 millisieverts (mSv) respectively (P...

Summary Objectives The study aims to assess the effects of family‐based interventions targeted parents only or parents‐and‐child for prevention and treatment childhood obesity. Method An open‐label randomized was conducted in 247 children (166 girls, 5–11 years) with body mass index (BMI) 85–98th percentile. Participants were allocated three groups: parents‐only ( n = 89), 84) follow‐up alone 74). intervention consisted 12 once‐weekly meetings a dietician psychologist. All followed 2 years....

To assess clinical variables, including early thyroid scintigraphy, in predicting the outcome (permanent vs transient) term infants with congenital hypothyroidism (CH).In a retrospective study, 142 full-term CH diagnosed between 2000 and 2012 were categorized into three groups: agenesis/ectopic permanent CH; eutopic transient CH. All underwent scintigraphy under regular follow-up our tertiary Pediatric Endocrine Institute.Thyroid scan showed 58 (41%) 84 (59%) infants. Imaging findings...

<b><i>Introduction:</i></b> The association of anemia with dementia in elders is controversial. We examined the potential a large population elders. <b><i>Methods:</i></b> Historical-prospective registry-based study. Included 36,951 community-dwelling (65–113 years) that were followed during 2002–2012. Anemia all kinds was defined according to Clalit Health Services (CHS) definitions: hemoglobin (HGB) <14 g/dL men, <12 women;...

To evaluate the risk for congenital malformations diagnosed at birth following assisted reproductive technology (ART) treatments compared with live births conceived spontaneously.A retrospective cohort study including 9042 ART and 213 288 spontaneously (SC) during period 1997-2004.The was linked to national registry determine outcome of pregnancies malformations.An increased adjusted all observed in SC infants [2.4% versus 1.9%; ORadj = 1.45; 95% CI: 1.26, 1.68]. The singleton 1.8%; 1.41;...

Background Among children conceived by assisted reproductive technology (ART), increased risk of adverse birth outcomes has been observed, including multiple births, preterm and congenital malformations. Regarding cancer among ART-conceived children, findings are discrepant. Methods This is a historical cohort 9,042 211,763 spontaneously (SC) born from 1997 through 2004. The median duration follow-up was 10.6 years (interquartile range 9.0–12.3) in the ART group 9.3 8.0–10.6) SC group....

The purpose of this work was to use the comprehensive computerized database Clalit Health Services analyze prevalence and contributing factors anemia among population Services-insured Israeli infants aged 9 18 months, characterized by ethnic sector.This a cross-sectional retrospective study for year 2003 using 34,512 months insured sick fund. Children with abnormal white blood counts at time hemoglobin test chronic diseases were excluded. data analyzed age, infant level, origin, district...