Because of the nucleotide sequence diversity different isolates hepatitis C virus, it has become important to clarify whether distinct genotypes virus vary with respect pathogenicity, infectivity, response antiviral therapy and geographic clustering. We assessed variability in 5' noncoding region using restriction enzymes analyze distribution genotypes, 80 patients chronic infection. Genotypes were correlated demographic, clinical histological features. Thirty-seven infected type 1, 10 had 2...

Abstract: Background: Experience with lamivudine treatment of immunocompetent patients acute hepatitis B is limited. Aim study: To evaluate the safety and efficacy for severe virus (HBV) infection in adults. Patients Methods: Fifteen (10 men, 5 women, mean age 34.3±7.3 years) HBV were treated 100 mg daily 3–6 months, starting 3–12 weeks after onset infection. Prior to treatment, had grade 1–4 encephalopathy; all coagulopathy (mean INR was 4.5±6.4), evidence hepatocyte lysis alanine...

Clinical diagnosis of acute diverticulitis is currently confirmed by an abdominal computerized tomography (CT). Common practice has been to perform a colonoscopy after the event exclude other diagnoses, mainly colon cancer. Our aim was evaluate yield early colonoscopy.Medical records 220 patients hospitalized for between June 1, 2002 and September 2009 were reviewed. Acute diagnosed clinical criteria characteristic CT findings. Fifteen excluded either because questionable or hematochezia....

Abstract Background Squamous cellular carcinoma antigen (SCCA) is overexpressed in hepatocellular (HCC) tissue and sera of HCC patients. Our aim was to assess hepatic SCCA immunostaining a series HCCs correlate its presence with cell proliferation, apoptosis clinical outcome. Methods Sixty-one patients were included. Liver specimens obtained either by biopsy (n = 17) or surgically (resection 27, transplantation 17). Immunostaining for AFP, Ki-67, TUNEL assay performed. Results staining...

The hepatic histology in nonalcoholic fatty liver disease can vary from isolated steatosis to steatohepatitis progress cirrhosis and liver-related death. aim was evaluate the use of blood serum N-glycan fingerprinting as a tool for differential diagnosis steatosis. A group 47 patients with NAFLD diagnosed by clinical laboratory analysis ultrasonography, studied histologically using Brunt's scoring system. control included 13 healthy individuals. profiles proteins were determined DNA...

High levels of profibrinogenic cytokine transforming factor beta (TGF-β), metalloprotease (MMP2), and tissue inhibitor matrix 1 (TIMP1) contribute to fibrogenesis in hepatitis C virus (HCV) infection alcohol-induced liver disease (ALD). The aim our study was correlate noninvasive serum markers ALD HCV patients with various degrees inflammation fibrosis their biopsies. Methods. Serum cytokines HCV-infected individuals the presence or absence were measured. Student's-t-test Bonferroni...

<b><i>Introduction:</i></b> The association of anemia with dementia in elders is controversial. We examined the potential a large population elders. <b><i>Methods:</i></b> Historical-prospective registry-based study. Included 36,951 community-dwelling (65–113 years) that were followed during 2002–2012. Anemia all kinds was defined according to Clalit Health Services (CHS) definitions: hemoglobin (HGB) <14 g/dL men, <12 women;...

Hepatitis B (HBV) infection remains a significant epidemiological problem in the end-stage renal disease (ESRD) population. Vaccination programs using second-generation vaccines lead to effective seroprotection only 50-60% of these patients. The purpose this case series was describe our experience with novel third-generation vaccine, Bio-Hep-B, ESRD patients who had not developed protective anti-HBs titers following HBV vaccination protocol. Twenty-nine responded past standard protocol were...

Summary. The mechanism underlying disease progression in hepatitis B virus (HBV) infection is unknown. Immunoglobulins stimulate the proliferative activity of rat hepatic stellate cells vitro . A strong association was found between serum immunoglobulin levels and fibrosis patients with C infection. Our objective to determine if same index could also be used chronic HBV records 100 biochemical, serological, virological histological evidence were reviewed for background factors globulin...

Rats given fructose-enriched diet develop many characteristics of the human metabolic syndrome and non-alcoholic fatty liver disease. In this study, we characterized hepatic effects rosiglitazone in rats. were randomly divided into three groups. One group was maintained on standard rat chow for 6 weeks, whereas other two groups weeks. Four weeks after initiation diet, one also (10 mg/kg/day) an additional 2 Rosiglitazone administration to rats associated with decreases following parameters:...

Toll-like receptor 4 (TLR4) is expressed on hepatic non-parenchymal cells and hepatocytes. Hepatic signaling through TLR4 critical in the pathogenesis of ischemia reperfusion injury (IRI) leads to release cytokines. The role bone marrow-derived early stage unclear.We used wild type mice (WT), TLR4deficient (TLR4ko) chimeras dissociate between expression liver (TLR4ko/WT) immuno-hematopoietic system (WT/TLR4ko) mouse IR model. Mice were subjected vivo partial IRI (70% for 60 min).Compared...

Data on the yield of conventional colonoscopy in very old patients remain limited. The aim study was to evaluate outcome nonagenarian patients.The safety, success rate complete and findings colonoscopies performed during last 5 years our center were compared between 41 nonagenarians (group 1) 2 control groups: 50 consecutive aged 70 79 2) 59 3). Serum hemoglobin, albumin, patients' source, indications for retrieved total cohort comorbidities, mental functional states group 1 only. Reasons...

Background The 13C-caffeine breath test (CBT) is a noninvasive tool for the evaluation of cytochrome P450 system, implicated in development nonalcoholic steatohepatitis. Goal To apply CBT to assess extent hepatic fibrosis patients with fatty liver disease (NAFLD). Methods Twenty-six consecutive (mean age 56.1±6.85 y, 69.2% women) NAFLD underwent CBT, addition clinical and laboratory evaluations biopsy. Ten healthy individuals matched served as controls. Results Mean delta over baseline...

Background Threshold values for 13 C‐urea breath test (13C‐ UBT ) positivity may be affected by various sociodemographic, host, bacterial, and laboratory factors. Manufacturer recommended cutoffs 13C‐ assays not applicable in all settings. Optimizing have profound public health ramifications. We aimed to determine the optimal threshold our population. Methods Consecutive samples collected at central from patients undergoing a first‐time between 1 January 2010 31 December 2015 were included....

Abstract Background Patient’s with Barrett’s esophagus (BE) are at risk of progression to esophageal adenocarcinoma (EAC). Neutrophil lymphocyte ratio (NLR) was found be a predictor poor prognosis in patients EAC; however, its performance premalignant lesions is vague. We aimed evaluate the utility NLR as histologic BE. Methods A prospective cohort proven BE tertiary referral center retrospectively analyzed. All biopsies were reviewed by an expert gastrointestinal pathologist. The...

Chronic hepatitis B virus (HBV) is associated with increased morbidity and mortality in patients chronic renal failure (CRF) transplant recipients. Lamivudine (3TC) has been shown to be a potent inhibitor of HBV replication. It appears safe effective CRF, though experience still limited. We describe 4 CRF on hemodialysis who showed rapid full response 3TC, administered for median 10 months. All had serum alanine transferase (ALT) levels 3 6 times the upper limit normal prior treatment,...

Serum alanine aminotransferase (ALT) levels below and above the reference range have been found to serve as a marker of liver injury predict all-cause mortality. The need adjust by age, sex, or other parameters remains unclear. current serum ALT in Israel is 0-34 IU/l for women 0-45 men. We aimed test applicability values specific people - elderly population.A retrospective design was used. study population consisted community-dwelling individuals aged at least 65 years who were tested 2002...

The progression of HCV-related disease is particularly aggressive in the post-transplantation setting. Recipients with recurrent HCV infection undergo repeated liver biopsies order to estimate progression. A strong association was found between serum immunoglobulins levels and hepatic fibrosis non-transplanted patients chronic infection. aim this study determine if globulin can predict extent records 45 (mean age 51.6 +/- 10.5 yr; 53.3% men) biochemical, serologic, virologic, histological...

Background: Patients' selection for transanal endoscopic microsurgery (TEM) depends on diagnostic modalities; however, there are still some limitations in the preoperative diagnosis of rectal lesions, and reports, up to third adenomas resected by TEM were found be adenocarcinoma; therefore, salvage radical resection (RR) remains necessary achieving oncological resection. Salvage RR may encounter technical problems as violation mesorectum scar formation. In this study, we aimed report outcome...