A5032226024- Dialysis and Renal Disease Management
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Central Venous Catheters and Hemodialysis
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- Pharmacological Effects and Toxicity Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Angiogenesis and VEGF in Cancer
- Potassium and Related Disorders
- Electrolyte and hormonal disorders
- Genetic and Kidney Cyst Diseases
- Ion Transport and Channel Regulation
- Birth, Development, and Health
- Organ Donation and Transplantation
- Renal and related cancers
- Iron Metabolism and Disorders
- Pediatric Urology and Nephrology Studies
- Hepatitis Viruses Studies and Epidemiology
Tel Aviv University
2004-2021
Tel Aviv Sourasky Medical Center
2006-2021
Rabin Medical Center
1997-2005
Lev Hasharon Hospital
1986-1995
ABSTRACT. Vascular endothelial growth factor (VEGF), an angiogenic for cells, is produced by glomerular and tubular epithelia. Using immunoelectron microscopy, VEGF expression podocytes (GEC) the proximal epithelium of rat kidney was confirmed. To elucidate mechanisms production its physiologic consequences, studies were performed in cultured GEC epithelial cells (RPTEC). Both RPTEC expressed VEGF-120 164 mRNA, as detected quantitative RT-PCR. Hypoxia resulted increase mRNA abundance, more...
Abstract Background: Hyperkalemia, induced by renin‐angiotensin‐aldosterone system inhibition (RAAS‐I) in patients with chronic kidney disease (CKD), or cardiac often leads to withdrawal of RAAS‐I therapy. Sodium polystyrene sulfonate (SPS) is a potassium‐binding resin used for the treatment hyperkalemia. Recently, concerns about safety and efficacy SPS were raised. We report here follow‐up 14 CKD heart on who treated low‐dose daily prevent recurrence Hypothesis: Daily safe effective...
Hepatitis B (HBV) infection remains a significant epidemiological problem in the end-stage renal disease (ESRD) population. Vaccination programs using second-generation vaccines lead to effective seroprotection only 50-60% of these patients. The purpose this case series was describe our experience with novel third-generation vaccine, Bio-Hep-B, ESRD patients who had not developed protective anti-HBs titers following HBV vaccination protocol. Twenty-nine responded past standard protocol were...
Mesangial cell (MC) proliferation is essential for the pathogenesis and progression of glomerular disease. Using an acute model mesangial proliferative glomerulonephritis (Thy1 GN), we show that neutralization interleukin (IL)-10 greatly ameliorated disease as expressed by both decreased MC expansion proteinuria. Treatment with tellurium compound AS101 (ammonium trichloro(dioxoethylene-o,o')tellurate) resulted in favorable effects provided was administered 24 h before insult, whereas partial...
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation angiogenesis. In addition, highly sulfated proteoglycans are important constituents of glomerular basement membrane its permselective properties. Recent studies suggest a role for heparanase in several experimental human diseases proteinuria such as diabetes, minimal change disease,...
Decreased generation of nitric oxide (NO) by endothelial NO synthase (eNOS) characterizes dysfunction (ECD). Delivery arginine to eNOS cationic amino acid transporter-1 (CAT-1) was shown modulate activity. We found in female rats, but not males, that CAT-1 activity is preserved with age and chronic renal failure, two experimental models ECD. In contrast, during pregnancy inhibited. hypothesize sex hormones regulate transport. Arginine uptake human umbilical vein cells (HUVEC) determined...
ABSTRACT. Mesangial cell (MC) proliferation is essential for the pathogenesis and progression of various glomerular diseases. This study shows that glial line-derived neurotrophic factor (GDNF) IL-10 are mesangial autocrine growth factors play a pivotal role in rat MC vitro. Downstream targets GDNF signaling their hyperplasia identified. The phosphatidylinositol 3-kinase (PI3K) pathway its downstream target NF-κB were found to mediate GDNF-induced mitogenesis. also mediates decrease...
Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in large sample apparently healthy individuals with no baseline albuminuria. This cross-sectional study 2,027 adults overt diseases who took part health survey program had Diagnosis MS based on...
C-reactive protein (CRP) is a recognized marker of systemic inflammation. Its association with carotid and femoral intima media thickness (surrogate measures atherosclerosis) may explain excess cardiovascular disease risk in hemodialysis patients.To estimate the between CRP both IMT (HD) patients; to predict these patients.The present cross-sectional study nested Sevelamer hydrochloride ultrasound-measured progression end-stage renal (SUMMER) clinical trial. Carotid (common, internal,...
Development of micro- and macrovascular disease in diabetes mellitus (DM) warrants a thorough investigation into the repertoire endothelial cell (EC) responses to diabetic environmental cues. Using human umbilical vein EC (HUVEC) cultured three-dimensional (3-D) native collagen I (NC) or glycated (GC), we observed capillary cord formation that showed significant reduction branching when cells were GC. To gain insight molecular determinants this phenomenon, HUVEC subjected GC vs. NC studied...
Medical, ethical and financial dilemmas may arise in treating undocumented-uninsured patients with end-stage renal disease (ESRD). Hereby we describe the 10-year experience of ESRD a large public dialysis-unit. We evaluated medical files all chronic dialysis treated at Tel-Aviv Medical Center between years 2000–2010. Data for immigrant without documentation insurance were obtained. Clinical data compared an age-matched cohort 77 insured patients. Fifteen scheduled therapy mean length 2.3...
Pregnancy worsens renal function in females with chronic failure (CRF) through an unknown mechanism. Reduced nitric oxide (NO) generation induces injury. Arginine transport by cationic amino acid transporter-1 (CAT-1), which governs endothelial NO generation, is reduced both and pregnancy. We hypothesize that attenuated maternal glomerular arginine promotes damage CRF pregnant rats. In uremic rats, pregnancy induced a significant decrease cGMP (a measure of production) compared or alone...
We report a case of erythrocytosis in patient with end-stage renal failure on chronic hemodialysis. The polycystic kidney disease had an average Hb level 10 g/dl while hemodialysis for 3 years. He developed (Hb 17.6 g/dl) following cadaveric transplantation. No signs suggesting polycythemia vera were found. Nonrenal causes secondary such as anoxia, hemoglobinopathies or tumors excluded. Angiography showed artery occlusion the native kidney. Serum erythropoietin was 85 U/l (normal 52 ± 31...
<b><i>Background:</i></b> Malnutrition is a frequently observed disorder in patients with chronic kidney disease (CKD) receiving hemodialysis (HD). While variously defined, malnutrition condition among on HD. Prevalence estimates of Israeli HD have not been reported. <b><i>Objectives:</i></b> To survey nutrition intake patients; estimate risk prevalence; identify factors, and characterize patients. <b><i>Methods:</i></b>...
Increased malnutrition risk has been observed in more than 40% people on haemodialysis Israel. It is not clear that this homogeneously distributed among with versus without diabetes.To examine the influence of diabetes haemodialysis.This cross-sectional study included a representative sample 375 individuals treated hospital dialysis centres throughout Of these, 126 had diabetes. Dietary intake, biochemistry, anthropometric and hemodynamic measures were recorded. Malnutrition categories...