A5085070114- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Gaze Tracking and Assistive Technology
- Tactile and Sensory Interactions
- CCD and CMOS Imaging Sensors
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Vestibular and auditory disorders
- Genetic Neurodegenerative Diseases
- Microtubule and mitosis dynamics
- Retinal and Macular Surgery
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Cellular Mechanics and Interactions
- Pulmonary Hypertension Research and Treatments
- Ocular and Laser Science Research
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Visual perception and processing mechanisms
- Pericarditis and Cardiac Tamponade
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Mitochondrial Function and Pathology
- Heart Failure Treatment and Management
Jerusalem College of Technology
2015-2024
Johns Hopkins Hospital
2022
Johns Hopkins Medicine
2019-2022
Johns Hopkins University
2019-2022
Second Sight Medical Products
2011-2021
Kaplan Medical Center
1985-2017
Sami Shamoon College of Engineering
2012-2014
Sight and Life
2012
University of California, Santa Barbara
2004-2010
Bar-Ilan University
2004-2010
We show that within a living eukaryotic cell, mean square displacement of an engulfed microsphere shows enhanced diffusion scaling as ${t}^{3/2}$ at short times, with clear crossover to subdiffusive or ordinary longer times. The motion, observed nearby the nucleus, is due interactions microtubule-associated motor proteins rather than thermal Brownian motion. propose time-dependent friction introduced by intracellular polymer networks leads sub-ballistic analogous subdiffusion in passive...
<h3>Background/aims</h3> To determine to what extent subjects implanted with the Argus II retinal prosthesis can improve performance compared residual native vision in a spatial-motor task. <h3>Methods</h3> High-contrast square stimuli (5.85 cm sides) were displayed random locations on 19″ (48.3 cm) touch screen monitor located 12″ (30.5 front of subject. Subjects instructed locate and centre system then off (40 trials each). The coordinates location touched recorded. <h3>Results</h3>...
We study the motion of a probe driven by microtubule-associated motors within living eukaryotic cell. The measured mean square displacement, $〈{x(t)}^{2}〉$ engulfed 2 and $3\ensuremath{\mu}\mathrm{m}$ diameter microspheres shows enhanced diffusion scaling as ${t}^{3/2}$ at short times, with clear crossover to ordinary or subdiffusive scaling, i.e., ${t}^{\ensuremath{\gamma}}$ $\ensuremath{\gamma}$ less than equal 1, long times. Using optical tweezers we tried move bead cell in order relate...
<h3>Objective</h3>To investigate the ability of 28 blind subjects implanted with a 60-electrode Argus II (Second Sight Medical Products Inc) retinal prosthesis system to detect direction moving object.<h3>Methods</h3>Blind (bare light perception or worse in both eyes) retinitis pigmentosa were as part phase 1/2 feasibility study at multiple clinical sites worldwide. The experiment measured their motion high-contrast bar on flatscreen monitor 3 conditions: and 1-to-1 mapping spatial...
<h3>Objective</h3> To demonstrate that an epiretinal prosthesis can produce patterned visual perception in patients blinded by photoreceptor degeneration who have no other treatment options. <h3>Methods</h3> A totally blind subject with retinitis pigmentosa had a 16-electrode implanted. The implant is controlled wirelessly external computer or head-mounted video camera. Spatial vision was assessed measuring the subject's response to direct stimulation of patterns and comparing ability...
The Argus II epiretinal prosthesis has been developed to provide partial restoration of vision subjects blinded from outer retinal degenerative disease. Participants were surgically implanted with the system in United States and Europe a single arm, prospective, multicenter clinical trial. purpose this investigation was determine which factors affect electrical thresholds order inform surgical placement device.Electrode-retina electrode-fovea distances determined using SD-OCT fundus...
Saccadic eye movements are the result of neural decisions about where to move eyes. These based on visual information accumulated before saccade; however, during an ≈100-ms interval immediately initiation movement, new cannot influence decision. Does brain simply ignore presented this brief or is used for subsequent saccade? Our study examines how and when integrates through time drive saccades search. We introduce a technique, saccade-contingent reverse correlation, that measures course...
The Argus II 60 channel epiretinal prosthesis has been developed in order to provide partial restoration of vision subjects blinded from outer retinal degenerative disease. To date the device implanted 21 as part a feasibility study. In 6 month post-implantation door finding and line tracking orientation mobility testing, have shown improvements 86% 73%, respectively, for system on vs. off. high-contrast Square Localization tests using touch screen monitor 87% tested performed significantly...
<h3>Background</h3> The significance of admission blood glucose level in nondiabetic patients with heart failure (HF) is unknown. We examined the possible association between levels and outcome a large cohort hospitalized HF. <h3>Methods</h3> analyzed data 4102 HF, who were during prospective national survey. present study focuses on subgroup 1122 acute HF admitted because or exacerbation chronic <h3>Results</h3> In-hospital mortality was twice as high third tertile (7.2%) compared first...
Purpose: Visual scanning by sighted individuals is done using eye and head movements. In contrast, the Argus II solely movement, since movements can introduce localization errors. Here, we tested if a mode utilizing increases visual stability reduces in users. Methods: Eye positions were measured real-time used to shift region of interest (ROI) that sent implant within wide field view (FOV) scene camera. Participants able use combined eye-head scanning: shifting camera moving their ROI FOV...
The dynamics of a polymer network are studied by direct view observation the motion single point within polymer. Taking advantage rather rigid biological microtubules as case study, we expand space and time scales system to those accessible optical microscopy standard video tools. Tracking is achieved chemically attaching an optically resolved microsphere on filament. We study this point, without spatial averaging inherent in scattering methods. It shown that mean square displacement...
Vestibulo-Ocular Reflex (VOR) abnormalities in cerebellar ataxias are a matter of renewed interest. We have previously reported vestibular areflexia group Yemenite-Jews with Spinocerebellar Ataxia Type 3 (SCA3) who had clear bilateral pathological horizontal Head Impulse Test (HIT). The objective this study was to evaluate the VOR ten SCA3 patients variable bedside HIT responses by recording their eye movements using magnetic search coils and correlate these results clinical genetic data....
Purpose: To quantify the precision of mapping from retinotopic (retina-centered) to spatiotopic (world-centered) coordinates in blind humans implanted with a retinal prosthesis device. Additionally, demonstrate that an eye tracker can be calibrated on sightless patients based percept visual implant. Methods: We directly activated epiretinal electrodes create stimuli and recorded location at world-based coordinates. In contrast normal Argus II use where stimulation is function captured...
The purpose of this study was to determine the coronary angiographic correlations (specifically disease left anterior descending artery) reciprocal ST segment depression appearing during inferior acute myocardial infarction. Forty six patients (41 men and five women; mean age 56 years) were allocated into two groups based on extent precordial depression: widespread (V1-V6) v localised (V1-V4) depression. Patients with no or in V1-V4 but elevation V5 V6 (inferolateral infarction) excluded....
Restoring sight for the blind using electrical stimulation of visual pathways is feasible but demands an understanding spatial mapping world at site targeted stimulation, whether in retina, thalamus, or cortex. While a cortex stimulator can bypass eye and create percepts, there inherent dissociation between this movements. It unknown how robustly brain maintains oculomotor circuitry patients with bare- no-light perception.To critically quantitatively evaluate effect movements have on...
Eye movements during fixation of a stationary target prevent the adaptation photoreceptors to continuous illumination and inhibit fading image. These random, involuntary, small, are restricted at long time scales so as keep center field view. Here we use Detrended Fluctuation Analysis (DFA) in order study properties fixational eye different scales. Results show scaling behavior between horizontal vertical movements. When small ballistics movements, i.e. micro-saccades, removed, exponents...
The imaging depth of field (DOF) white-light illuminated objects is extended by carefully integrating two image-processing techniques, one optical and digital. technique makes use a tailored phase mask positioned at the pupil system to cause different color channels have focal lengths; accordingly, phase-mask equipped acquires high resolution reasonably focused image in least three, red, green, blue (RGB), any location within specified DOF. digital processing comprises fusing separate RGB...
To investigate the effect of a wider field-of-view (FOV) retinal prosthesis on users' performance in locating objects.One female and four male subjects who were blind due to end-stage retinitis pigmentosa had been implanted with Argus II participated (aged 63.4 ± 15.4). Thermal imaging was captured by an external sensor converted electrical stimulation retina. Subjects asked localize reach for heat-emitting objects using two different FOV mappings: normal 1:1 mapping (no zoom) that provided...