Michal J. Simchen

ORCID: 0000-0003-3921-7461
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About
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Research Areas
  • Pregnancy and preeclampsia studies
  • Assisted Reproductive Technology and Twin Pregnancy
  • Neonatal Respiratory Health Research
  • Prenatal Screening and Diagnostics
  • Cardiovascular Issues in Pregnancy
  • Blood Coagulation and Thrombosis Mechanisms
  • Birth, Development, and Health
  • Maternal and fetal healthcare
  • Systemic Lupus Erythematosus Research
  • Renal Diseases and Glomerulopathies
  • Infant Development and Preterm Care
  • Platelet Disorders and Treatments
  • Preterm Birth and Chorioamnionitis
  • Gestational Diabetes Research and Management
  • Hemoglobinopathies and Related Disorders
  • Maternal and Perinatal Health Interventions
  • Cardiac Structural Anomalies and Repair
  • Parvovirus B19 Infection Studies
  • Infant Nutrition and Health
  • Venous Thromboembolism Diagnosis and Management
  • Pregnancy-related medical research
  • Blood groups and transfusion
  • Connective tissue disorders research
  • Neonatal and fetal brain pathology
  • Liver Diseases and Immunity

Sheba Medical Center
2014-2024

Tel Aviv University
2014-2024

Edmond and Lily Safra Children's Hospital
2016

Israel National Institute for Health Policy Research
2014

Beijing Obstetrics and Gynecology Hospital
2014

University of Toronto
2001-2006

Mount Sinai Hospital
2002-2005

Society for Maternal-Fetal Medicine
2004-2005

Sinai Hospital
2001-2004

Lunenfeld-Tanenbaum Research Institute
2004

To compare maternal and neonatal outcomes of term large for gestational age (LGA) pregnancies adequate (AGA) pregnancies.Retrospective analysis.Large university research medical center.All singleton LGA (birthweight ≥ 90th percentile) AGA 10.1-89.9th delivering between 2004 2008.Data collected included age, at delivery, mode birthweight, fetal sex, complications. Birthweight percentiles were determined according to locally derived gender-specific birthweight tables.Comparisons 90-94.9th,...

10.1111/j.1600-0412.2012.01412.x article EN Acta Obstetricia Et Gynecologica Scandinavica 2012-04-04

Background:To compare maternal and neonatal outcomes of term macrosomic adequate for gestational age (AGA) pregnancies.Material/Methods: A retrospective analysis was performed on all singleton (birth weight ≥4000 g) AGA >10 th percentile <4000 pregnancies delivered at our hospital between 2004 2008.Data collected included age, delivery, mode birth weight, fetal gender, complications.Comparisons were made different severities macrosomia (4000-4250 g, 4250-4500 g ≥4500 g). Results:The study...

10.12659/msm.883340 article EN Medical Science Monitor 2012-01-01

The objective of this paper is to examine whether growth-restricted preterm infants have a different neonatal outcome than appropriately grown infants. All consecutive, singleton deliveries between 27-35 weeks' gestation were included over 4-year period. Infants with congenital anomalies and diabetic mothers excluded. categorized as small-for-gestational-age (SGA) when birth weight was at or below the 10th percentile, appropriate-for-gestational-age (AGA) 11th 90th percentiles. Outcome...

10.1055/s-2000-9423 article EN American Journal of Perinatology 2000-01-01

The objective was to investigate the role of infant and maternal thrombophilia in a cohort mothers infants presenting with perinatal arterial ischemic stroke.Forty-seven clinically radiologically confirmed stroke underwent workup: factor V Leiden (FVL), PII20210A mutation, Methylene-tetrahydrofolate reductase 677T polymorphism, protein C, S, antithrombin, FVIII, antiphospholipid antibodies. Thrombophilia data were available for 23 mother-infant pairs compared control populations evaluate...

10.1161/strokeaha.108.527283 article EN Stroke 2008-10-17

Abstract The effect of additional treatments combined with conventional therapy on pregnancy outcomes was examined in high-risk primary antiphospholipid syndrome (PAPS) patients to identify the most effective treatment strategy. study's inclusion criteria were (1) positivity lupus anticoagulant alone or associated anticardiolipin and/or anti-β2 glycoprotein I antibodies; (2) a history severe maternal–foetal complications (Group I) one more pregnancies refractory leading unexplained foetal...

10.1055/s-0038-1632388 article EN Thrombosis and Haemostasis 2018-02-28

To evaluate obstetric outcome after stillbirth according to placental and prothrombotic risk factors.Obstetric outcomes of women with prior subsequent pregnancies were reviewed. Data on the immediate pregnancy included fetal loss, stillbirth, obstetric/medical complications, gestational age birth weight at delivery, mode thrombophilia, prescribed medication. Placental was defined as associated abruption, intrauterine growth restriction (IUGR), or histological evidence infarcts. Controls...

10.1515/jpm-2013-0013 article EN Journal of Perinatal Medicine 2013-04-11

In Brief OBJECTIVE: To evaluate pregnancy complications occurring after age 50. METHODS: We compared the outcomes of women aged 50–64 years with those 45–49 and general population. RESULTS: During 5 from January 1, 1999, to June 30, 2004, 123 45 older gave birth. Fifty-five percent were nulliparous, 24 years, 99 years. All than 50 conceived via in vitro fertilization oocyte donation. For these women, overall mean gestational at delivery was 37.6±2.6 weeks. The birth weight 2,684±754 g,...

10.1097/01.aog.0000240139.46018.bd article EN Obstetrics and Gynecology 2006-11-01

To investigate whether in patients with antiphospholipid syndrome (APS), high positive antibody titers are associated adverse pregnancy outcome.A retrospective cohort study of prospectively collected data.Sheba Medical Center, Israel, a tertiary referral center. POPULATION SAMPLE: Pregnant women APS.Anticardiolipin, a-β2-glycoprotein I antibodies, and lupus anticoagulant were measured before pregnancy. Women divided into those >four times the upper limit normal (high titer, HPT group), rest,...

10.1111/j.1600-0412.2011.01236.x article EN Acta Obstetricia Et Gynecologica Scandinavica 2011-07-06

To estimate the influence of intrauterine growth restriction (IUGR) on outcome preterm discordant twins.Medical records twins born at 24-34 weeks gestation between 1995 and 2000 were reviewed. Significant discordancy was defined as more than 15% difference in birth weight. Small for gestational age (SGA) weight less 10th percentile, according to a twin-adjusted nomogram. The smaller 96 twin pairs evaluated. SGA-discordant group included pair who also SGA (n = 46);...

10.1097/01.aog.0000146634.28459.e8 article EN Obstetrics and Gynecology 2005-01-01

We aimed to investigate whether multifetal pregnancies are at risk of more pregnancy complications in women advanced age after ovum donation.Pregnancy outcome donation aged 40 and above was extracted. Labor delivery data as well antenatal records carrying twins were compared with those singletons, a control group all twin delivered Sheba Medical Center during 2007.One hundred twenty-five > or = studied. Of those, 42 carried 83 singletons. The comprised the study 417 twins. Mean maternal 49.2...

10.1093/humrep/dep238 article EN Human Reproduction 2009-07-05

The objective of this study is to identify the risk factors for neonatal thrombocytopenia among preterm infants. During a 4-year period all consecutive, singleton deliveries (between 27 and 35 weeks gestation) were evaluated, separate cohorts compared-growth restricted (small-for-gestational-age; SGA) appropriately grown (appropriate-for-gestational-age; AGA) An initial comparison was done presence (platelet count below 150,000/mL) marked (below 100,000/mL). Following that, made between...

10.1055/s-2003-37948 article EN American Journal of Perinatology 2003-01-01

Sex differences in long and short-term outcomes for infants are observed. This has also been shown several neonatal complications preterm neonates. We aimed to evaluate whether sex impacts outcome among term Furthermore, we were interested small-for-gestational age male female neonates at presented with different patterns of complications.Data on all singleton deliveries respective between 2004 2008 a single tertiary medical center utilized this retrospective cohort study. Immediate...

10.3109/14767058.2013.845658 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2013-09-18

YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel and MJS contributed equally to the study should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis persistently elevated titers antiphospholipid antibodies (aPL) in neonatal period. Our aim was investigate course impact aPL a cohort infants presenting either perinatal arterial ischemic stroke (PAS) or cerebral sinus...

10.1177/0961203314531842 article EN Lupus 2014-04-11

To present our experience with fetuses umbilical vein varix (UVV), to investigate possible risk factors and suggest a management scheme of evaluation.A study 14 pregnancies complicated isolated UVV was performed. Data collected included sonographic characteristics the UVV, pregnancy outcome including induction labour, mode delivery, birthweight, neonatal complications.UVV diagnosed at median gestational age 27.5 weeks' gestation (range: 22-34 weeks). The average diameter diagnosis 10.6 mm...

10.1002/pd.2219 article EN Prenatal Diagnosis 2009-02-26

To evaluate the perinatal outcome of MC twins with selective IUGR (sIUGR).A prospective study, which included three groups twins: Group A, uncomplicated twin pregnancies (n = 91); group B, sIUGR normal umbilical artery Doppler 19); and C, abnormal (absence or reversed EDV) 18). The latter were routinely hospitalized in high-risk ward under strict surveillance.Neonatal fetuses complicated was similar to controls. Neonates born by had significantly increased incidence CNS findings, RDS, NEC,...

10.1375/twin.14.5.457 article EN Twin Research and Human Genetics 2011-10-01

Abstract Objective: To compare indications for delivery and neonatal morbidities between twins singletons born 34 35 weeks of gestation. Study design: A prospective observational study was performed in which all infants January August 2008, at Sheba Medical Center 0/7–35 6/7 gestational age were included. Indications delivery, infants’ medical interventions documented. Twins compared antenatal maternal characteristics, risks short-term complications interventions. Results: One hundred...

10.1515/jpm-2015-0113 article EN Journal of Perinatal Medicine 2015-12-17
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