A5076980114- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Pelvic floor disorders treatments
- Blood Coagulation and Thrombosis Mechanisms
- Congenital Heart Disease Studies
- Pelvic and Acetabular Injuries
- Pregnancy and Medication Impact
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Adipose Tissue and Metabolism
- Gestational Trophoblastic Disease Studies
- Gynecological conditions and treatments
- Neonatal and Maternal Infections
Kaplan Medical Center
2015-2024
Hebrew University of Jerusalem
2013-2024
National Institutes of Health
2008-2022
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2007-2022
Wayne State University
2008-2017
United States Department of Health and Human Services
2008-2017
Eunice Kennedy Shriver Center
2008-2012
Hutzel Women's Hospital
2008-2010
Detroit Medical Center
2010
The role played by microbial invasion of the amniotic cavity (MIAC) in preterm pre-labor rupture membranes (pPROM) is inadequately characterized, part because reliance on cultivation-based methods.Amniotic fluid from 204 subjects with pPROM was analyzed both cultivation and molecular methods a retrospective cohort study. Broad-range group-specific polymerase chain reaction (PCR) assays targeted small subunit ribosomal DNA (rDNA), or other gene sequences, bacteria, fungi, archaea. Results...
Changes in the maternal plasma concentrations of angiogenic (placental growth factor (PlGF) and vascular endothelial (VEGF)) anti-angiogenic factors (sEng receptor-1 (sVEGFR-1)) precede clinical presentation preeclampsia. This study was conducted to examine role PlGF, sEng, sVEGFR-1 early pregnancy midtrimester identification patients destined develop
Biomarkers for preterm labor (PTL) and delivery can be discovered through the analysis of transcriptome (transcriptomics) protein composition (proteomics). Characterization global changes in low-molecular weight compounds which constitute 'metabolic network' cells (metabolome) is now possible by using a 'metabolomics' approach. Metabolomic profiling has special advantages over transcriptomics proteomics since metabolic network downstream from gene expression synthesis, thus more closely...
Objective. The anti-inflammatory limb of the immune response is crucial for dampening inflammation. Spontaneous parturition at term and preterm labor (PTL) are mediated by inflammation in cervix, membranes, myometrium. This study focuses on changes amniotic fluid concentrations cytokine interleukin (IL)- 10. objectives this were to determine whether there a relationship between IL-10 gestational age, (at preterm), intra-amniotic infection/inflammation (IAI).Study design. A cross-sectional...
The syndromic nature of spontaneous labour was a concept first proposed in 1994 [1]. It has important implications for understanding the biology preterm parturition, and also, setting realistic ...
Objective. Caspase-1 is a component of the NALP3 inflammasome, cytosolic multiprotein complex that mediates processing pro-inflammatory caspases and cytokines. The inflammasome represents first line defense against cellular stress crucial innate immunity. enzyme responsible for cleavage activation interleukin (IL)-1β, which potent cytokine, plays central role in mechanisms leading to labor (preterm term) particularly context intrauterine infection/inflammation. In addition, caspase-1 cleaves...
Objective. Heat shock protein (HSP) 70, a conserved member of the stress family, is produced in almost all cell types response to wide range stressful stimuli, and its production has survival value. Evidence suggests that extracellular HSP70 involved activation innate adaptive immune response. Furthermore, increased mRNA expression been observed human fetal membranes following endotoxin stimulation. This study was conducted determine changes amniotic fluid concentrations during pregnancy,...
Objective: Infection has been implicated in the pathogenesis of preeclampsia, yet association between microbial invasion amniotic cavity (MIAC) and preeclampsia not determined. The aim this study was to determine prevalence, diversity associated with MIAC, as well nature host response MIAC patients preeclampsia.
Objective: Microbial invasion of the amniotic cavity (MIAC) has been detected in women with preterm labor, prelabor rupture membranes (PROM), and patients at term PROM or spontaneous labor. Intrauterine infection is recognized as a potential cause fetal growth restriction; yet, frequency MIAC pregnancies small-for-gestational-age (SGA) fetuses unknown. The aim this study was to determine frequency, diversity relative abundance microbes fluid (AF) an SGA neonate using combination culture...
Objective. An imbalance between angiogenic and anti-angiogenic factors in maternal blood has been observed several obstetrical syndromes including preeclampsia, pregnancies with fetal growth restriction death. Vascular lesions have identified a subset of patients spontaneous preterm labor (PTL). It is possible that PTL may be one the manifestations an state. The aim this study was to determine if prior clinical diagnosis leading delivery had plasma concentrations different from normal...
The aim of this study was to identify changes in the cervical transcriptome human uterine cervix as a function ripening before onset labor.Human tissue obtained from women at term not labor with ripe (n = 11) and unripe cervices profiled using Affymetrix GeneChip HGU133Plus2.0 arrays. Gene expression analyzed moderated t-test (False Discovery Rate 5%). ontology pathway analysis were performed. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) used for confirmation...
Objective. Examination of the amniotic fluid (AF) proteome has been previously attempted to identify useful biomarkers in predicting outcome preterm labor (PTL). Isobaric Tag for Relative and Absolute Quantitation (iTRAQ™) labeling allows direct ratiometric comparison relative abundance identified protein species among multiplexed samples. The purpose this study was apply, first time, combination iTRAQ tandem mass spectrometry proteins differentially regulated AF samples women with...
Intrauterine devices (IUDs) are used for contraception worldwide; however, the management of pregnancies with an IUD poses a clinical challenge. The purpose this study was to determine outcome pregnancy in patients IUD.