A5004844213- Cardiac electrophysiology and arrhythmias
- Evolution and Paleontology Studies
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Ion channel regulation and function
- Pharmacogenetics and Drug Metabolism
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Pregnancy and preeclampsia studies
- Cardiomyopathy and Myosin Studies
- Lipoproteins and Cardiovascular Health
- Gene expression and cancer classification
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Genomics and Rare Diseases
- Receptor Mechanisms and Signaling
- Pregnancy-related medical research
- Plant Taxonomy and Phylogenetics
- Botanical Studies and Applications
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Fungal and yeast genetics research
- Cholesterol and Lipid Metabolism
- Colorectal Cancer Treatments and Studies
Wright State University
2022
Transgenomic (United States)
2011-2012
Mayo Clinic
2005-2012
University of Amsterdam
2012
Amsterdam UMC Location University of Amsterdam
2009-2012
MaineHealth
2007-2010
Duke University
2008
Center for Human Genetics
2008
Biohaven Pharmaceuticals (United States)
2001-2007
Case Western Reserve University
2006
Background— Genetic testing for long-QT syndrome (LQTS) has diagnostic, prognostic, and therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility genes have been identified. that includes the 3 most commonly mutated is available clinically. Distinguishing pathogenic from innocuous rare variants critical to interpretation test results. We sought quantify value mutation type gene/protein region determining probability pathogenicity mutations. Methods Results—...
Clozapine is considered to be the most efficacious drug treat schizophrenia, although it underutilized, partially due a side effect of agranulocytosis. This analysis 74 candidate genes was designed identify an association between sequence variants and clozapine-induced agranulocytosis (CIA).Blood medical history were collected for 33 CIA cases 54 clozapine-treated controls enrolled April 2002 December 2003. Significant markers from 4 then assessed in independently case-control cohort (49...
Pre-eclampsia (PE) affects 5–7% of pregnancies in the US, and is a leading cause maternal death perinatal morbidity mortality worldwide. To identify genes with role PE, we conducted large-scale association study evaluating 775 SNPs 190 candidate selected for potential obstetrical complications. SNP discovery was performed by DNA sequencing, genotyping carried out high-throughput facility using MassARRAY<sup>TM</sup> System. Women PE (n = 394) their offspring 324) were compared...
A set of experiments based on simulation and analysis found that using the parsimony algorithm for ancestral state estimation can benefit from increased sampling terminal taxa. Estimation at base small clades showed strong sensitivity to tree topology number descendent tips. These effects were largely driven by creation negation ambiguity across a topology. Root internal similar behavior. We conclude taxon density is generally advisable, attention topological may be advisable in evaluating...
Background— There is interindividual variation in low-density lipoprotein cholesterol (LDLc) lowering by statins and limited study into the genetic associations of dose dependant LDLc statins. Methods Results— Five hundred nine patients with hyperlipidemia were randomly assigned atorvastatin 10 mg, simvastatin 20 or pravastatin mg (low-dose phase) followed 80 40 (high-dose phase), respectively. Thirty-one genes statin, cholesterol, metabolism sequenced 489 single nucleotide polymorphisms...
Background— Hundreds of nonsynonymous single nucleotide variants (nsSNVs) have been identified in the 2 most common long-QT syndrome-susceptibility genes ( KCNQ1 and KCNH2 ). Unfortunately, an ≈3% background rate rare nsSNVs amongst healthy individuals complicates ability to distinguish pathogenic mutations from similarly yet presumably innocuous variants. Methods Results— In this study, 4 tools [(1) conservation across species, (2) Grantham values, (3) sorting intolerant tolerant, (4)...
Background Intermittent fasting (IF) is an increasingly popular approach to dietary control that focuses on the timing of eating rather than quantity and content caloric intake. IF practitioners typically seek improve their weight other health factors. Millions have turned purpose-built mobile apps help them track adhere fasts monitor changes in biometrics. Objective This study aimed quantify user retention, patterns, loss by users 2 apps. We also sought describe model starting BMI, amount...
Background Next-generation sequencing (NGS), including whole genome (WGS) and exome (WES), is increasingly being used for clinic care. While NGS data have the potential to be repurposed support clinical pharmacogenomics (PGx), current computational approaches not been widely validated using data. In this study, we assessed accuracy of Aldy method extract PGx genotypes from WGS WES 14 13 major pharmacogenes, respectively. Methods Germline DNA was isolated blood samples collected 264 patients...