A5101905834- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Endometriosis Research and Treatment
- Acupuncture Treatment Research Studies
- Colorectal Cancer Screening and Detection
- Medical Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Kruppel-like factors research
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Gestational Trophoblastic Disease Studies
- Adipose Tissue and Metabolism
- Caveolin-1 and cellular processes
Shaoguan Railway Hospital
2025
Air Force Medical University
2013-2024
Xijing Hospital
2015-2024
Heilongjiang University of Chinese Medicine
2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Yunnan Investment Group (China)
2023
Nanchang University
2022-2023
Fudan University Shanghai Cancer Center
2019-2022
Shanghai Medical College of Fudan University
2019-2021
Anhui Provincial Children's Hospital
2021
The gut microbiome is involved in antitumor immunotherapy and chemotherapy responses; however, evidence-based research on the role of predicting response to neoadjuvant chemoradiotherapy (nCRT) patients with locally advanced rectal cancer (LARC) remains scarce. This prospective, longitudinal study aimed evaluate feasibility nCRT responses.We collected 167 fecal samples from 84 LARC before after 31 specimens healthy individuals for 16S rRNA sequencing. Patients were divided into responders...
Clozapine is considered to be the most efficacious drug treat schizophrenia, although it underutilized, partially due a side effect of agranulocytosis. This analysis 74 candidate genes was designed identify an association between sequence variants and clozapine-induced agranulocytosis (CIA).Blood medical history were collected for 33 CIA cases 54 clozapine-treated controls enrolled April 2002 December 2003. Significant markers from 4 then assessed in independently case-control cohort (49...
Abstract Purpose: PS-341 (bortezomib, Velcade), the first proteasome inhibitor approved by Food and Drug Administration for treatment of patients with relapsed multiple myeloma, induces apoptosis in human cancer cell lines. Vitamin C (ascorbic acid) is an essential water-soluble vitamin required many normal physiologic functions has to be obtained through diet or supplemental tablets humans. Here we studied potential effect on anticancer activity Experimental Design: The effects induction...
AimsApelin, an endogenous cytokine, has a number of biological effects on the cardiovascular system, including cardioprotective effect and calcium modulation. Because intracellular abnormality is considered to play important role in cardiac dysfunction induced by ischaemia–reperfusion (I/R), aim this study was examine apelin-13 I/R-induced changes performance sarcoplasmic reticulum (SR) function.
Abstract Objective Neuroendocrine carcinoma of the cervix (NECC) is a rare malignancy with poor clinical prognosis due to limited therapeutic options. This study aimed establish risk-stratification score and nomogram models predict in NECC patients. Methods Data on individuals diagnosed between 2000 2019 were retrieved from Surveillance Epidemiology End Results (SEER) database then randomly classified into training validation cohorts (7:3). Univariate multivariate Cox regression analyses...
Objective: To discuss the feasibility and safety of stage I anastomosis T-tube fistulation in laparoscopic local resection duodenal tumors. Methods: A descriptive case series study was used to retrospectively analyze clinical diagnosis treatment data 14 patients with tumors who successfully underwent + phase ostomy Guangdong Provincial Hospital Chinese Medicine First Affiliated Guangzhou University from October 2021 March 2024. The reconstruction steps tumor are as follows: (1) after safe...
Abstract Human blastocyst nidation in the uterus and successful pregnancy require coordinated endometrial expression of estrogen receptor (ER)-α, progesterone receptors (PR)-A -B gap junction protein, connexin (Cx)43. Our prior work established that inflammation associated with conditions reduced fecundity, particularly endometriosis, can perturb eutopic decidual function. In current studies, we have modeled decidualization primary human stromal cell cultures derived from normal controls...
Abstract Purpose It is recommended for colorectal cancer to harvest at least 12 lymph nodes (LNs) during surgery avoid understaging of the disease. However, it still controversial whether necessary from locally advanced rectal (LARC) patients who underwent neoadjuvant chemoradiotherapy (neo‐CRT). The impact node yield (LNY) on prognosis in LARC was analyzed. Materials/Methods In total, 495 neo‐CRT 2006‐2015 were After examining clinicopathological distribution differences between LNY...
Breast cancer 1, early onset (BRCA1)-interacting protein 1 (BRIP1), a DNA-dependent adenosine triphosphatase and DNA helicase, is required for BRCA-associated damage repair functions, may be associated with the tumorigenesis aggressiveness of various cancers. The present study investigated expression BRIP1 in normal cervix tissues cervical carcinoma via reverse transcription-quantitative polymerase chain reaction (RT-qPCR) immunohistochemistry assays. was observed to reduced squamous tissue...
Anti-tumor drug resistance and cancer metastasis are always clinically coincidental, which conducted by different molecules such as P-glycoprotein (P-gp) CD147, respectively. P-gp CD147/CD98hc complex both found highly expressed on cisplatin resistant ovarian cell line SKOV3/DDP but only slightly its parent SKOV3. RNAi targeting CD98hc or CD147 reduce their own expression well IC50 of drug-resistant tumor cells. interference reduced membrane rather than intracellular forms. Stop also...
Abstract Background In view of the fact that there is no effective treatment for dementia, number years dementia patients have to live with will gradually increase rest their lives, and disability loss caused by increase. It urgent study influence risk factors on making use potential prevention. The purpose this quantify burden attributable assessing population fractions (PAFs) in Jiangxi Province, which one regions moderate aging process China. Methods prevalence data nine were obtained...
Intracerebral hemorrhage (ICH) manifests precipitously and profoundly impairs the neurological function in patients who are affected. The etiology of subsequent injury post-ICH is multifaceted, characterized by intricate interplay various factors, rendering therapeutic interventions challenging. Astrocytes, a distinct class glial cells, interact with neurons microglia, implicated series pathophysiological alterations following ICH. A comprehensive examination functions mechanisms associated...
Abstract Objective To evaluate the prognostic factors and survival outcome of patients with surgically treated high-grade neuroendocrine carcinoma cervix (NECC). Methods It was a multi-center, retrospective study that involved 98 cervical cancer stage IA2-IIIC NECC. We divided them into two groups based on histology: pure group mixed group. All clinicopathological variables were evaluated retrospectively. Cox regression Kaplan-Meier methods used for analysis. Results In our study, 60 in 38...
Abstract Objective To evaluate the prognostic factors and survival outcomes of patients with surgically treated high‐grade neuroendocrine carcinoma cervix (NECC). Methods This multicenter, retrospective study involved 98 cervical cancer stage IA2–IIA2 IIIC1/2p NECC. We divided into two groups based on histology: pure mixed groups. All clinicopathologic variables were retrospectively evaluated. Cox regression Kaplan–Meier methods used for analysis. Results In our study, 60 in group 38 group....
Ovarian cancer is the highest mortality rate of all female reproductive malignancies. Drug resistance a major cause treatment failure in malignant tumors. Hepatitis B X-interacting protein acts as an oncoprotein, regulates cell proliferation, and migration breast cancer. We aimed to investigate effects mechanisms hepatitis on cisplatin human ovarian lines. The mRNA levels were detected using RT-PCR Western blotting cisplatin-resistant cisplatin-sensitive tissues, lines A2780/CP SKOV3/CP,...
Abstract Background Tumor deposits (TDs) have been identified as an independent prognostic factor in gastric cancer (GC). However, the associated clinicopathological factors and how to simply reasonably incorporate TD into TNM staging system remain undetermined. The aim of current study was therefore assess significance among radically resected GC patients. Methods We retrospectively reviewed 1915 patients undergoing radical resection between 2007 2012. were classified two groups according...
Substantial evidence has demonstrated that tumor-infiltrating lymphocytes (TILs) are correlated with patient prognosis. The TIL-based immune score (IS) affects prognosis in various cancers, but its prognostic impact gastric cancer (GC) patients treated adjuvant chemoradiotherapy remains unclear.A total of 101 GC who received after gastrectomy were retrospectively analyzed this study. Immunohistochemistry staining for CD3+ and CD8+ T-cell counts both tumor center (CT) invasive margin (IM)...
Although adjuvant chemoradiotherapy (CRT) used to be recommended as a standard of care for locally advanced gastric cancer, this suggestion has been strongly challenged recently. However, clear evidence regarding the optimization radiotherapy is lacking. The purpose study was compare effectiveness preoperative CRT versus that postoperative resectable or potentially cancer.From January 2005 December 2017, patients with clinical stage III/IVa (i.e., T3-4aN+M0 T4bNxM0) cancer were...