Giving an old organelle the heave-ho Centrioles are ancient cellular organelles that build centrosomes, major microtubule-organizing centers in animal cells. Duplication of centrioles is tightly controlled to ensure each dividing cell has precisely two centrosomes. Human cancer cells often have extra which been hypothesized confer a proliferative advantage. Wong et al. developed small molecules (centrinones) allowed them reversibly “delete” from (see Perspective by Stearns). Surprisingly,...

Abstract In this paper, we propose a new ultra‐wideband (UWB) antenna for UWB applications. The proposed is designed to operate from 3.2 12 GHz. It consists of rectangular patch with two steps, single slot on the patch, and partial ground plane. Details design measured results are presented discussed. © 2004 Wiley Periodicals, Inc. Microwave Opt Technol Lett 40: 399–401, 2004; Published online in InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11392

Cilia are microtubule-based projections that function in the movement of extracellular fluid. This requires cilia to be: (1) motile and driven by dynein complexes (2) correctly polarized on surface cells, which planar cell polarity (PCP). Few factors regulate both processes have been discovered. We reveal C21orf59/Kurly (Kur), a cytoplasmic protein with some enrichment at base cilia, is needed for motility; zebrafish mutants exhibit characteristic developmental abnormalities arm defects. kur...

Apo-E–deficient apo-B100–only mice (Apoe–/–Apob100/100) and LDL receptor–deficient (Ldlr–/–Apob100/100) have similar total plasma cholesterol levels, but nearly all of the in former animals is packaged VLDL particles, whereas, latter, found smaller particles. We compared apo-B100–containing lipoprotein populations these to determine their relation susceptibility atherosclerosis. The median size particles Apoe–/–Apob100/100 was 53.4 nm versus only 22.1 Ldlr–/–Apob100/100 plasma. levels...

Objective. An imbalance between angiogenic and anti-angiogenic factors in maternal blood has been observed several obstetrical syndromes including preeclampsia, pregnancies with fetal growth restriction death. Vascular lesions have identified a subset of patients spontaneous preterm labor (PTL). It is possible that PTL may be one the manifestations an state. The aim this study was to determine if prior clinical diagnosis leading delivery had plasma concentrations different from normal...

The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in mouse human heart tissue. Why the would express these "lipoprotein assembly" has been unclear. Here we demonstrate that beating actually secretes spherical lipoproteins. Moreover, increased cardiac production of lipoproteins (<i>e.g</i>., mice a transgene) was associated with secretion from decreased stores triglycerides within heart. Increased also reduced pathological accumulation occurs hearts...

The directed movement of cells is critical for numerous developmental and disease processes. A developmentally reiterated form migration radial intercalation; the process by which move in a direction orthogonal to plane tissue from an inner layer outer layer. We use intercalation into skin Xenopus laevis embryos as model study cell within epithelial tissue. identify novel function both microtubule-binding protein CLAMP members microtubule-regulating Par complex during intercalation....

Abstract Crumpled graphene (CGR) is considered a promising supercapacitor material to achieve high power and energy density because it could overcome the disadvantages of 2 D GR sheets such as aggregation during electrode fabrication process, reduction available surface area, limitation electron ion transport. Even though CGR shows good results, carbon materials are limited in terms their capacitance performance. Here, we report highly enhanced by fabricating 3 composite containing CGR,...

Microsomal triglyceride transfer protein (MTP) transfers lipids to apolipoprotein B (apoB) within the endoplasmic reticulum, a process that involves direct interactions between apoB and large subunit of MTP. Recent studies with heterozygous MTP knockout mice have suggested half-normal levels in liver reduce secretion. We hypothesized reduced secretion setting might be caused by MTP:apoB ratio which would number apoB-MTP interactions. If this hypothesis were true, little impact on lipoprotein...

Post-translational modification of tubulin provides differential functions to microtubule networks. Here, we address the role acetylation on penetrative capacity cells undergoing radial intercalation, which is process by move apically, insert between outer cells, and join an epithelium. There are opposing forces that regulate namely, restrictive epithelial barrier versus intercalating cell. Positively negatively modulating in alters developmental timing such with more penetrate faster. We...

Most epithelial cells polarize along the axis of tissue, a feature known as planar cell polarity (PCP). The initiation PCP requires cell–cell signaling via noncanonical Wnt/PCP pathway. Additionally, changes in cytoskeleton both facilitate and reflect this polarity. We have identified CLAMP/Spef1 novel regulator signaling. In addition to decorating microtubules (MTs) ciliary rootlet, pool CLAMP localizes at apical cortex. Depletion leads loss protein asymmetry, defects cilia polarity, angle...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntrinsic Kinetics of the Reaction between Oxygen and Carbonaceous Residue in Retorted Oil ShaleHong Yong Sohn Sun K. KimCite this: Ind. Eng. Chem. Process Des. Dev. 1980, 19, 4, 550–555Publication Date (Print):October 1, 1980Publication History Published online1 May 2002Published inissue 1 October 1980https://pubs.acs.org/doi/10.1021/i260076a008https://doi.org/10.1021/i260076a008research-articleACS PublicationsRequest reuse permissionsArticle...

Objective Cross‐talk between inflammation and angiogenesis pathways has been recently reported. The objectives of this study were to: (i) examine whether amniotic fluid ( AF ) concentrations soluble endoglin (sEng), a protein with anti‐angiogenic properties, change during pregnancy, parturition, or intra‐amniotic infection and/or IAI ); (ii) determine an increase in sEng the patients preterm labor PTL prelabor rupture membranes PROM is associated adverse neonatal outcomes; (iii) investigate...

Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late-stage development, there is dramatic remodeling of the that involves complete loss MCCs. Cell extrusion well-characterized process for driving cell while maintaining epithelial barrier function. Normal typically unidirectional, whereas bidirectional often associated disease (e.g. cancer). We describe two distinct mechanisms MCC extrusion, basal driven by Notch signaling and an...

Recently, manufacturing companies have been moving into product-based service businesses in addition to providing the products themselves. However, it is not easy for engineers create new because their skills, mental models, design processes, and organization are optimized product design. In order services more effectively efficiently, systematic methodologies suitable necessary. Based on case analysis of than 40 Japan-US services, this paper introduces a methodology called DFACE-SI....

Woolly mammoths were among the most abundant cold-adapted species during Pleistocene. Their once-large populations went extinct in two waves, an end-Pleistocene extinction of continental followed by mid-Holocene relict on St. Paul Island ∼5,600 years ago and Wrangel ∼4,000 ago. experienced episode rapid demographic decline coincident with their isolation, leading to a small population, reduced genetic diversity, fixation putatively deleterious alleles, but functional consequences these...

Abstract In this paper, we propose a new dual‐band antenna for applications of the ISM band. The proposed is designed to operate at 2.4 and 5.8 GHz. lower‐frequency band (2.4 GHz) can be obtained by using meandering technique, upper‐frequency (5.8 operation was achieved embedding backed microstrip line. Details design experimental results are presented discussed. measured radiation patterns GHz gain across respective frequency bands also presented. © 2004 Wiley Periodicals, Inc. Microwave...

Recently, manufacturing companies have been moving into product-based service businesses in addition to providing the products themselves. However, it is not easy for engineers create new because their skills, mental models, design processes, and organization are optimized product design. In order services more effectively efficiently, systematic methodologies suitable necessary. Based on case analysis of than 40 Japan-US services, this paper introduces a methodology called DFACE-SI....

Slowing sales growth for new products and falling profit margins have made adding services to an increasingly attractive means of competitive differentiation manufacturing-based companies. In response this trend, paper examines ways that companies can leverage their core competencies design as business. It explores why a company should go into service businesses in the first place. From surveys, interviews financial analyses multiple companies, we discovered often stabilise total revenue...

Basal plasma tissue type plasminogen activator (t-PA) and inhibitor 1 (PAI-1) antigen levels were studied in 49 non-insulin dependent diabetic patients (23 men, 26 women: ages 51.3±14.9 years) 16 age matched non-diabetic subjects (9 7 49.8±12.2 as a control group. Compared to group, the had significantly higher mean t-PA (5.15±3.02 vs 3.20±2.30 ng/ml) PAI-1 (35.89±18.59 17.60±15.36 (p<0.05). Plasma level was not influenced by each treatment modality. There significant decrease of after...

An inverse heat conduction problem for nanoscale structure is studied. The phenomenon modeled using the Boltzmann transport equation. Phonon-mediated in one dimension considered. One boundary exposed to an unknown temperature and other boundary, where observation takes place, subject a known condition. A sequential scheme with constant function specification employed estimation of temperature. Sample results are presented discussed.

An investigation of tape layup process a thermoplastic composite (APC-2) using nitrogen torch is conducted. The distribution heat transfer coefficient along the surfaces estimated via three-dimensional flow analysis, and surface temperature obtained through two-dimensional conduction analysis finite element method (FEM). are so interrelated that it poses conjugate problem. Thus, sought simultaneously in an iterative fashion. computational results presented for specific case.