A5036512275- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Platelet Disorders and Treatments
- Global Health Workforce Issues
- Lipid metabolism and disorders
- Cardiovascular Issues in Pregnancy
- Cancer, Lipids, and Metabolism
- Porphyrin Metabolism and Disorders
- Poisoning and overdose treatments
- Cardiac Arrhythmias and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Mechanical Circulatory Support Devices
University Hospital of Bern
2020-2025
University of Bern
2020-2025
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2020
University of Fribourg
2014-2016
To validate the set of clinical and biochemical criteria proposed by consensus Academic Research Consortium (ARC) for High Bleeding Risk (HBR) identification HBR patients. These were categorized into major minor, if expected to carry in isolation, respectively, ≥4% <4% (BARC) 3 or 5 bleeding risk within 1-year after percutaneous coronary intervention (PCI). patients are those meeting at least 1 2 minor criteria.All undergoing PCI Bern University Hospital, between February 2009 September 2018...
Severe mitral regurgitation (MR) following acute myocardial infarction (MI) is associated with high mortality rates and has inconclusive recommendations in clinical guidelines. We aimed to report the international experience of patients secondary MR MI compare outcomes those treated conservatively, surgically, percutaneously.Retrospective registry consecutive at least moderate-to-severe 21 centres North America, Europe, Middle East. The included conservatively having surgical valve repair or...
Background: Accurate bleeding risk stratification after percutaneous coronary intervention (PCI) is important for treatment individualization. However, there still an unmet need a more precise and standardized identification of high patients. We derived validated novel score by augmenting the PRECISE-DAPT with Academic Research Consortium High Bleeding Risk (ARC-HBR) criteria. Methods: The derivation cohort comprised 29,188 patients undergoing PCI, whom 1136 (3.9%) had (BARC) 3 or 5 at 1...
Background Female sex was not included among the high bleeding risk (HBR) criteria by Academic Research Consortium (ARC) as it remains unclear whether constitutes an HBR condition after percutaneous coronary intervention. We investigated female associates with and assessed performance of ARC separately in women men. Methods Results Among all consecutive patients undergoing intervention between 2009 2018, occurrences up to 1 year were prospectively collected centrally adjudicated. All but one...
The identification of bleeding risk factors in patients undergoing percutaneous coronary intervention (PCI) is essential to inform subsequent management. Whether clinical presentation per se affects after PCI remains unclear.We aimed assess whether predisposes and if the Academic Research Consortium (ARC) High Bleeding Risk (HBR) criteria perform consistently acute (ACS) chronic (CCS) syndrome patients.Consecutive from Bern Registry were stratified by presentation. events at one year...
We present the first case in Switzerland of a patient with homozygous familial hypercholesterolaemia treated evinacumab, new recombinant human monoclonal antibody currently approved Europe and USA but not yet Switzerland. Homozygous is rare genetic disorder that causes severely elevated levels low-density lipoprotein (LDL) cholesterol early atherosclerotic cardiovascular disease, which, if left untreated, can lead to premature death. As result this newly introduced treatment, patient’s LDL...
This cohort study evaluates the outcomes associated with deferred vs expedited aortic valve replacement in patients severe stenosis during COVID-19 pandemic.
Objectives The objective of this study was to characterize a population patients with severe tricuspid regurgitation (TR) evaluated at tertiary care center, assess mid-term clinical outcomes, and identify prognostic factors. Background impact TR on morbidity mortality is increasingly recognized. Clinical characteristics long-term outcomes suffering from remain unclear. Methods This retrospective observational single-center hospital including echocardiographic diagnosis between January 2017...
Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter valve repair may therefore be a suitable therapy. However, data on clinical outcomes patients in acute setting are scarce, especially those reduced left ventricle (LV) dysfunction. We conducted multinational, collaborative analysis from 21 centers for who were, within 90 days MI, treated MitraClip due to MR. The cohort was divided according median ejection...
Second-generation everolimus-eluting stents (EES) and third generation biolimus-eluting (BES) have been shown to be superior first-generation paclitaxel-eluting (PES) second-generation sirolimus-eluting (SES). However, neointimal proliferation very late stent thrombosis is still an unresolved issue of drug-eluting (DES) implantation overall. The Absorb™ (Abbott Vascular, Abbott Park, IL, USA) the first CE approved DES with a bioresorbable vascular scaffold (BVS) thought reduce long-term...
The study sought to assess the procedural success of rotational atherectomy (RA) in coronary chronic total occlusion (CTO) and investigate in-hospital one-year outcomes following RA. From 2015 2019, patients undergoing percutaneous intervention for CTO (CTO PCI) were retrospectively included into hospital database. primary endpoint was success. Secondary endpoints major adverse cardiovascular cerebral event (MACCE) rates. During period 5 years, 2.789 underwent PCI. Patients treated with RA...
Dual anti-platelet therapy (DAPT) with clopidogrel and acetylsalicylic acid (ASA) has previously been recommended after transcatheter aortic valve implantation (TAVI) is still the standard of care in patients who underwent coronary stent placement within 3 months prior to TAVI. This study sought evaluate whether on-treatment platelet reactivity a predictor for occurrence bleeding events enrolled 484 undergoing TAVI from November 2013 until April 2018. Patients were either on long-term DAPT...
Head-to-head optical coherence tomography (OCT) data comparing metallic stents with bioresorbable vascular scaffolds (BVS) are lacking. This study assessed healing at 9-month follow-up after implantation of everolimus- and biolimus-eluting (EES; BES) everolimus-eluting BVS.OCT was performed in 74 patients enrolled the EVERBIO II (NCT01711931) trial (23 EES: 26 lesions, 7 625 struts; 23 BES: 6 140 28 BVS: 33 10 891 struts). OCT images were acquired using pullback nonocclusive flushing...
Abstract Aims The ESC/EACTS guidelines propose criteria that determine the likelihood of true-severe aortic stenosis (AS). We aimed to investigate impact guideline-based AS in patients with low-flow low-gradient (LFLG) preserved ejection fraction (pEF) on outcomes following transcatheter valve replacement (TAVR). Methods and results In a prospective TAVR registry, LFLG-AS pEF were retrospectively categorized into high (criteria ≥6) intermediate &lt;6) AS. Haemodynamic, functional,...
Background-Fractional flow reserve (FFR) measurements are recommended for assessing hemodynamic coronary stenosis severity. Intracoronary ECG (icECG) is easily obtainable and highly sensitive in detecting myocardial ischemia due to its close vicinity the myocardium. We hypothesized that remission time of on icECG after a controlled occlusion accurately detects hemodynamically relevant stenosis. Methods-This retrospective, observational study included patients with chronic syndrome undergoing...
We aimed at addressing the association between serum lipoprotein (a) levels and clinical outcomes of consecutive patients undergoing PCI. used PCI Heart Center University Freiburg, Bad Krozingen in Germany January 2005 November 2013. A total 6679 (men [n = 5391] women 1288]) with mean age 67.5 (± 11.1) years were assessed baseline prospectively followed for 3 years. Lp(a) measurement was performed hospital admission as a routine laboratory parameter. Approximately 30% showed an elevated...