A5041144284- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Radioactive Decay and Measurement Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Scientific Computing and Data Management
- Radioactive contamination and transfer
- Digital Radiography and Breast Imaging
- CAR-T cell therapy research
- Radiation Detection and Scintillator Technologies
- Dental Health and Care Utilization
- Peptidase Inhibition and Analysis
- AI in cancer detection
- Advanced MRI Techniques and Applications
- Artificial Intelligence in Healthcare and Education
- Global Security and Public Health
Memorial Sloan Kettering Cancer Center
2017-2025
Yahoo (United Kingdom)
2023
Kettering University
2018
University of Colorado Anschutz Medical Campus
2014-2017
University of Colorado Denver
2014-2016
University of Colorado Boulder
2014
Hadassah Medical Center
2013
International Atomic Energy Agency
2010-2012
University of California, Los Angeles
2006-2010
UCLA Medical Center
2008
Medical internal radiation dosimetry constitutes a fundamental aspect of diagnosis, treatment, optimization, and safety in nuclear medicine. The MIRD committee the Society Nuclear Medicine Imaging developed new computational tool to support organ-level suborgan tissue (MIRDcalc, version 1). Based on standard Excel spreadsheet platform, MIRDcalc provides enhanced capabilities facilitate radiopharmaceutical dosimetry. This implements well-established schema for incorporates significantly...
Positron emission tomography (PET) is increasingly used for the detection, characterization, and follow-up of tumors located in thorax. However, patient respiratory motion presents a unique limitation that hinders application high-resolution PET technology this type imaging. Efforts to transcend have been underway more than decade, yet remains practical considerations modality vulnerable motion-induced image degradation. Respiratory control not employed routine clinical operations. In...
The application of radiopharmaceutical therapy for the treatment certain diseases is well established, and field expanding. New therapeutic radiopharmaceuticals have been developed in recent years, more are research pipeline. Concurrently, there growing interest use internal dosimetry as a means personalizing, potentially optimizing, such patients. Internal multifaceted, current state art discussed this continuing education article. Topics include context dosimetry, methods, advantages...
Purpose: Respiratory gating in PET is an approach used to minimize the negative effects of respiratory motion on spatial resolution. It based initial determination a patient's movements during scan, typically using hardware systems. In recent years, several fully automated databased algorithms have been presented for extracting signal directly from data, providing very practical strategy implementing clinic. this work, new method raw sinogram data and compared previously techniques. Methods:...
Purpose To assess the performance of hardware- and software-gating technologies in terms qualitative quantitative characteristics respiratory motion positron emission tomography (PET) imaging. Materials Methods Between 2010 2013, 219 fluorine 18 fluorodeoxyglucose PET examinations were performed 116 patients for assessment pulmonary nodules. All provided informed consent this institutional review board-approved study. Acquisitions reconstructed as respiratory-gated images by using...
Accurate quantification in emission tomography is essential for internal radiopharmaceutical therapy dosimetry. Mean activity concentration measurements objects with diameters less than 10 times the full width at half maximum of imaging system's spatial resolution are significantly affected (>10%) by partial-volume effect. This study develops a framework PET and SPECT characterization proposes 2 MIRD recovery coefficient models—a geometric mean approximation (RECOVER-GM) an empirical...
Abstract Background Prior to selective internal radiotherapy of liver tumors, a determination the lung shunt fraction (LSF) is performed using 99mTc- macroaggregated albumin (99mTc-MAA) injected into hepatic artery. Most commonly planar but sometimes SPECT/CT images are acquired upon which regions interests drawn manually define and lung. The LSF then calculated by taking count ratios between these two organs. An accurate estimation necessary avoid an excessive pulmonary irradiation dose....
Radiopharmaceutical dosimetry is usually estimated via organ-level MIRD schema-style formalisms, which form the computational basis for commonly used clinical and research software. Recently, MIRDcalc internal software was developed to provide a freely available solution that incorporates up-to-date models of human anatomy, addresses uncertainty in radiopharmaceutical biokinetics patient organ masses, offers 1-screen user interface as well quality assurance tools. The present work describes...
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Respiratory motion in PET degrades image quality and limits detectability of small or low-contrast lesions. Although can be improved using respiratory-gating, this adds to the complexity expense acquiring data. We aimed develop a data-driven method, based on individual voxel signal fluctuations, for accomplishing electronic respiratory gating clinical data, requiring no additional hardware end-user input. tested our methods both simulated scans actual human acquisitions. For simulations,...
SUMMARY Background Delta-like ligand 3 (DLL3) is aberrantly expressed on the cell surface in many neuroendocrine cancers including small lung cancer (SCLC) and prostate (NEPC). Several therapeutic agents targeting DLL3 are active clinical development. Molecular imaging of would enable non-invasive diagnostic assessment to inform use DLL3-targeting therapeutics or assess disease treatment response. Methods We conducted a first-in-human immuno-positron emission tomography (immunoPET) study [...
<sup>90</sup>Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food Drug Administration–approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based planning. Several different mathematical models are used calculate patient-specific prescribed activity <sup>90</sup>Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, dual compartment (partition). Under auspices...
Respiratory gating and gate optimization strategies present solutions for overcoming image degradation caused by respiratory motion in PET traditionally utilize hardware systems and/or employ complex processing algorithms. In this work, we aimed to advance recently emerging data-driven methods introduce a new strategy optimizing the four-dimensional data based on information contained that data. These algorithms are combined form an automated correction workflow.Software-based were applied...
Respiratory gating has been used in PET imaging to reduce the amount of image blurring caused by patient motion. Optimal binning is an approach for using motion-characterized data it into a single, easy understand/use, optimal bin. To date, protocols have utilized externally driven motion characterization strategies that tuned with population-derived assumptions and parameters. In this work, we are proposing new strategy which characterize directly from patient's gated scan, use signal...
In nuclear medicine, estimating the number of radioactive decays that occur in a source organ per unit administered activity radiopharmaceutical (i.e., time-integrated coefficient [TIAC]) is an essential task within internal dosimetry workflow. TIAC estimation commonly derived by least-squares fitting various exponential models to time-activity data (radiopharmaceutical biodistribution). Rarely, however, are methods used objectively determine model best characterizes data. Additionally,...