A5006680533- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Renal and related cancers
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Graphene and Nanomaterials Applications
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- HER2/EGFR in Cancer Research
- Biosimilars and Bioanalytical Methods
- Carbon Nanotubes in Composites
- Radiation Therapy and Dosimetry
- Protein Degradation and Inhibitors
Kettering University
2016-2025
Cornell University
2016-2025
Weill Cornell Medicine
2016-2025
Memorial Sloan Kettering Cancer Center
2016-2025
Tri-Institutional PhD Program in Chemical Biology
2021-2025
Eureka Therapeutics (United States)
2013-2023
Memorial Hospital
2020-2023
Parker Institute for Cancer Immunotherapy
2018-2020
Laboratory of Molecular Genetics
2018
New York Proton Center
2013-2015
Patients with acute promyelocytic leukemia have a characteristic (15;17) translocation, breakpoint on chromosome 17 in the region of retinoic acid receptor—alpha (RAR-α). Since this receptor has been shown to be involved growth and differentiation myeloid cells vitro, since recent clinical studies reported that tretinoin (all-trans-retinoic acid) induces complete remission patients leukemia, we studied effects cellular maturation molecular abnormalities undergoing induction agent.
Two reports from China have suggested that arsenic trioxide can induce complete remissions in patients with acute promyelocytic leukemia (APL). We evaluated this drug APL an attempt to elucidate its mechanism of action.
Medical scientists and public health policy makers are increasingly concerned that the scientific discoveries of past generation failing to be translated efficiently into tangible human benefit. This concern has generated several initiatives, including Clinical Research Roundtable at Institute Medicine, which first convened in June 2000. Representatives from a diverse group stakeholders nation's clinical research enterprise have collaborated address issues it faces. The context is encumbered...
To determine the safety and efficacy of arsenic trioxide (ATO) in patients with relapsed acute promyelocytic leukemia (APL).Forty experiencing first (n = 21) or > second 19) relapse were treated daily infusions ATO to a maximum 60 doses until all leukemic cells bone marrow eliminated. Patients who achieved complete remission (CR) offered one consolidation course that began 3 4 weeks later. remained CR eligible receive further cycles therapy on maintenance study.Thirty-four (85%) CR....
Tumor-infiltrating immune cells have been linked to prognosis and response immunotherapy; however, the levels of distinct cell subsets signals that draw them into a tumor, such as expression antigen presenting machinery genes, remain poorly characterized. Here, we employ gene expression-based computational method profile infiltration 24 populations in 19 cancer types. We compare types using an score T find clear renal carcinoma (ccRCC) is among highest for both scores. Using profiles well...
A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to molecular-sized generators of alpha-emitting isotope cascades the inside cancer cells using actinium-225 coupled internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate at becquerel (picocurie) levels. Injection single doses kilobecquerel (nanocurie) levels into mice bearing solid carcinoma or...
Single-walled carbon nanotubes (CNT) are mechanically robust graphene cylinders with a high aspect ratio that comprised of sp<sup>2</sup>-bonded atoms and possessing highly regular structures defined periodicity. CNT exhibit unique mechanochemical properties can be exploited for the development novel drug delivery platforms. We hypothesized prototype nanostructures consisting biologics, radionuclides, fluorochromes, could synthesized designed to target tumor cells. <b>Methods:</b>...
Tumors build vessels by cooption of pre-existing vasculature and de novo recruitment bone marrow (BM)-derived endothelial progenitor cells (EPCs). However, the contribution functional role EPCs in tumor neoangiogenesis are controversial. Therefore, using genetically marked BM cells, we demonstrate precise spatial temporal to neovascularization three transplanted one spontaneous breast vivo high-resolution microscopy flow cytometry. We show that early tumors recruit BM-derived differentiate...
The molecular weight cutoff for glomerular filtration is thought to be 30–50 kDa. Here we report rapid and efficient of molecules 10–20 times that mass a model the mechanism this filtration. We conducted multimodal imaging studies in mice investigate renal clearance single-walled carbon nanotube (SWCNT) construct covalently appended with ligands allowing simultaneous dynamic positron emission tomography, near-infrared fluorescence imaging, microscopy. These SWCNTs have length distribution...
Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated driver genes. Here we describe a high-throughput platform combining single-cell transcriptomic and T cell receptor (TCR) sequencing to establish whether mutant PIK3CA, among the most frequently genomically altered oncogenes, generates immunogenic public NeoAg. Using this strategy, developed panel TCRs that recognize endogenously processed neopeptide encompassing common...
Lintuzumab (HuM195), a humanized anti-CD33 antibody, targets myeloid leukemia cells and has modest single-agent activity against acute (AML). To increase the potency of antibody without nonspecific cytotoxicity associated with β-emitters, α-particle-emitting radionuclide bismuth-213 ((213)Bi) was conjugated to lintuzumab. This phase I/II trial conducted determine maximum tolerated dose (MTD) antileukemic effects (213)Bi-lintuzumab, first targeted α-emitter, after partially cytoreductive chemotherapy.
Lintuzumab (HuM195) is an unconjugated humanized murine monoclonal antibody directed against the cell surface myelomonocytic differentiation antigen CD33. In this study, efficacy of lintuzumab in combination with induction chemotherapy was compared alone adults first relapsed or primary refractory acute myeloid leukemia (AML).Patients resistant AML (duration response, zero to 12 months) were randomly assigned receive either mitoxantrone 8 mg/m(2), etoposide 80 and cytarabine 1 g/m(2) daily...
Ten patients with myeloid leukemias were treated in a phase I trial escalating doses of mouse monoclonal antibody (mAb) M195, reactive CD33, glycoprotein found on leukemia blasts and early hematopoietic progenitor cells but not normal stem cells. M195 was trace-labeled iodine-131 (131I) to allow detailed pharmacokinetic dosimetric studies by serial sampling blood bone marrow whole-body gamma-camera imaging. Total up 76 mg administered safely without immediate adverse effects. Absorption onto...
Abstract Vitamin C is an antioxidant vitamin that has been hypothesized to antagonize the effects of reactive oxygen species–generating antineoplastic drugs. The therapeutic efficacy widely used drugs doxorubicin, cisplatin, vincristine, methotrexate, and imatinib were compared in leukemia (K562) lymphoma (RL) cell lines with without pretreatment dehydroascorbic acid, commonly transported form C. effect on viability, clonogenicity, apoptosis, P-glycoprotein, species (ROS), mitochondrial...