Pedram Razavi
A5029733167- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- Nanowire Synthesis and Applications
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Multiple and Secondary Primary Cancers
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Cancer Treatment and Pharmacology
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
- Integrated Circuits and Semiconductor Failure Analysis
- Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2017-2024
Kettering University
2016-2024
University of California, San Diego
2021-2023
Weill Cornell Medicine
2022
Moores Cancer Center
2021
Icahn School of Medicine at Mount Sinai
2020
Eli Lilly (United States)
2020
Faculty of 1000 (United States)
2020
ORCID
2020
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper investigates the temperature dependence of main electrical parameters junctionless (JL) silicon nanowire transistors. Direct comparison is made to (trigate) MOSFETs. Variation such as threshold voltage and <emphasis emphasistype="smcaps">on</emphasis>– emphasistype="smcaps">off</emphasis> current characteristics analyzed. The JL FET has a lager variation with than standard inversion-...
Abstract Most mutations in cancer are rare, which complicates the identification of therapeutically significant and thus limits clinical impact genomic profiling patients with cancer. Here, we analyzed 24,592 cancers including 10,336 prospectively sequenced advanced disease to identify mutant residues arising more frequently than expected absence selection. We identified 1,165 statistically hotspot 80% arose 1 1,000 or fewer patients. Of 55 recurrent in-frame indels, validated that novel...
Abstract Recent studies have identified somatic ESR1 mutations in patients with metastatic breast cancer and found some of them to promote estrogen-independent activation the receptor. The degree which all recurrent mutants can drive activities reduced sensitivity ER antagonists like fulvestrant is not established. In this report, we characterize spectrum from more than 900 patients. were detected 10%, D538G being most frequent (36%), followed by Y537S (14%). Several novel, activating also...
The electric field perpendicular to the current flow is found be significantly lower in junctionless transistors than regular inversion-mode or accumulation-mode field-effect transistors. Since inversion channel mobility metal-oxide-semionductor reduced by this field, low transistor may give them an advantage terms of drive for nanometer-scale complementary metal-oxide semiconductor applications. This observation still applies when quantum confinement present.
This paper presents the evaluation of analog properties nMOS junctionless (JL) multigate transistors, comparing their performance with those exhibited by inversion-mode (IM) trigate devices similar dimensions. The study has been performed for operating in saturation as single-transistor amplifiers, and we have considered dependence on fin width <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">W</i> <sub...
Seeing double can be a good thing Many human breast cancers harbor activating mutations in PIK3CA , the gene coding for catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical trials are underway to evaluate efficacy PI3K inhibitors cancer patients. Vasan et al. found unexpectedly that subset not one—but two— mutations, and occur on same allele (see Perspective by Toker). In model systems, hyperactivate signaling enhance tumor growth. Preliminary analysis clinical trial data suggests...
Amplification of and oncogenic mutations in ERBB2, the gene encoding HER2 receptor tyrosine kinase, promote hyperactivation tumor growth. Here we demonstrate that ubiquitination internalization, rather than its overexpression, are key mechanisms underlying endocytosis consequent efficacy anti-HER2 antibody-drug conjugates (ADC) ado-trastuzumab emtansine (T-DM1) trastuzumab deruxtecan (T-DXd) lung cancer cell lines patient-derived xenograft models. These data translated into a 51% response...
Cyclin-dependent kinases 4 and 6 (CDK4/6) represent a major therapeutic vulnerability for breast cancer. The are clinically targeted via ATP competitive inhibitors (CDK4/6i); however, drug resistance commonly emerges over time. To understand CDK4/6i resistance, we surveyed 1,300 cancers identified several genetic alterations (e.g., FAT1, PTEN, or ARID1A loss) converging on upregulation of CDK6. Mechanistically, demonstrate CDK6 causes by inducing binding CDK inhibitor INK4 proteins...
Circulating cell-free DNA from blood plasma of cancer patients can be used to non-invasively interrogate somatic tumor alterations. Here we develop MSK-ACCESS (Memorial Sloan Kettering - Analysis cfDNA Examine Somatic Status), an NGS assay for detection very low frequency alterations in 129 genes. Analytical validation demonstrated 92% sensitivity de-novo mutation calling down 0.5% allele and 99% a priori profiling. To evaluate the performance MSK-ACCESS, report results 681 prospective...
Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated driver genes. Here we describe a high-throughput platform combining single-cell transcriptomic and T cell receptor (TCR) sequencing to establish whether mutant PIK3CA, among the most frequently genomically altered oncogenes, generates immunogenic public NeoAg. Using this strategy, developed panel TCRs that recognize endogenously processed neopeptide encompassing common...
Conduction mechanisms in junctionless nanowire transistors (gated resistors) are compared to inversion-mode and accumulation-mode MOS devices. The device uses bulk conduction instead of surface channel. current drive is controlled by doping concentration not gate capacitance. variation threshold voltage with physical parameters intrinsic performance analyzed. A scheme proposed for the fabrication devices on silicon.