A5077914746- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Particle Detector Development and Performance
- Digital Radiography and Breast Imaging
- Lymphoma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Radiation Dose and Imaging
- Electron and X-Ray Spectroscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
- CCD and CMOS Imaging Sensors
- Advanced X-ray Imaging Techniques
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Radioactive Decay and Measurement Techniques
- Cancer Cells and Metastasis
- Radioactivity and Radon Measurements
- Ion-surface interactions and analysis
- Immunotherapy and Immune Responses
University of Arizona
2013-2025
Banner - University Medical Center Tucson
2017-2024
Banner Health
2024
University of Colorado Anschutz Medical Campus
2018-2022
University of Colorado Denver
2018-2021
Solvay (Belgium)
2020
Pacific Northwest National Laboratory
2012-2017
University of Colorado System
2017
University of Glasgow
2006-2009
Sandia National Laboratories California
1996
In any gamma-ray detector, each event produces electrical signals on one or more circuit elements. From these signals, we may wish to determine the presence of an interaction; whether multiple interactions occurred; spatial coordinates in two three dimensions at least primary total energy deposited that interaction. We also want compute listmode probabilities for tomographic reconstruction. Maximum-likelihood methods provide a rigorous and some senses optimal approach extracting this...
Mesenchymal Stem Cells (MSCs) migrate specifically to tumors in vivo, and coupled with their capacity bypass immune surveillance, are attractive vehicles for tumor-targeted delivery of therapeutic agents. This study aimed introduce MSC-mediated expression the sodium iodide symporter (NIS) imaging therapy breast cancer. Tumor bearing animals received an intravenous or intratumoral injection NIS expressing MSCs (MSC-NIS), followed by (99m) Technetium pertechnetate 3-14 days later using a...
Purpose: Alpha‐emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over few cell diameters (50–80 μ m), causing localized, irreparable double‐strand DNA breaks that lead to death. Radioimmunotherapy (RIT) approaches using monoclonal antibodies labeled with α emitters may thus inactivate targeted cells minimal radiation damage surrounding tissues. Tools are needed visualize and quantify the radioactivity distribution...
Targeted alpha-particle therapy (TAT) might be a relevant therapeutic strategy to circumvent resistance conventional therapies in the case of HER2-positive metastatic cancer. Single-domain antibody fragments (sdAb) are promising vehicles for TAT because their excellent vivo properties, high target affinity, and fast clearance kinetics. This study combines cytotoxic α-particle emitter bismuth-213 (213Bi) HER2-targeting sdAbs. The vitro specificity, potency radiolabeled complex were analyzed...
Purpose Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses radiotherapy to tumor cells while minimizing exposure surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms radiophysical features. These differences may have important consequences absorbed dose tumors normal organs....
Abstract Targeted radiopharmaceutical therapy with alpha-particle emitters (αRPT) is advantageous in cancer treatment because the short range and high local energy deposition of alpha particles enable precise radiation delivery efficient tumor cell killing. However, these properties create sub-organ dose effects that are not easily characterized by direct gamma-ray imaging (PET or SPECT). We present a computational procedure to determine spatial distribution absorbed from alpha-emitting...
Human epidermal growth factor receptor type 2 (HER2) is overexpressed in various cancers; thus, HER2-targeting single-domain antibodies (sdAb) could offer a useful platform for radioimmunotherapy. In this study, we optimized the labeling of an anti-HER2-sdAb with α-particle-emitter 225Ac through DOTA-derivative. The formed radioconjugate was tested binding affinity, specificity and internalization properties, whereas cytotoxicity evaluated by clonogenic DNA double-strand-breaks assays....
We examined the spatial resolution of a columnar CsI(Tl), single-photon imaging system using an approach that estimates interaction position to better than spread light distribution. A scintillator was directly coupled 512×512 electron multiplying CCD (EMCCD) camera (16 μm pixels) binned at 2×2 sample 32 pixels. Optical photons from gamma-ray/scintillator interactions are sampled over multiple Resultant images show clusters signal original site, Cs and I K x-rays up several hundred microns...
FastSPECT III is a stationary, single-photon emission computed tomography (SPECT) imager designed specifically for imaging and studying neurological pathologies in rodent brain, including Alzheimer's Parkinsons's disease. Twenty independent BazookaSPECT [1] gamma-ray detectors acquire projections of spherical field view with pinholes selected desired resolution sensitivity. Each detector comprises columnar CsI(Tl) scintillator, image-intensifier, optical lens, fast-frame-rate CCD camera....
Recently, high-resolution gamma cameras have been developed with detectors containing > 105-106 elements. Single-photon emission computed tomography (SPECT) imagers based on these usually also a large number of voxel bins and therefore face memory storage issues for the system matrix when performing fast tomographic reconstructions using iterative algorithms. To address issues, we method that parameterizes detector response to point source generates fly during MLEM or OSEM graphics hardware....
Abstract Background Diffusing alpha‐emitters radiation therapy (“Alpha‐DaRT”) is a new method for treating solid tumors with alpha particles, relying on the release of short‐lived alpha‐emitting daughter atoms radium‐224 from interstitial sources inserted into tumor. Alpha‐DaRT tumor dosimetry governed by spread radium's progeny around source, as described an approximate framework called “diffusion‐leakage model”. The most important model parameters are diffusion lengths radon‐220 and...
Results are presented for a low-cost, ultra-high resolution gamma camera small-animal SPECT and molecular imaging. The detector, known as Bazooka SPECT, employs second-generation image intensifier which is directly coupled to columnar CsI(Tl) scintillator. Operating in photon-counting mode, individual gamma-ray interactions seen clusters of signal, significant improvement spatial obtained by estimating the interaction position via Anger (centroid) estimation clusters. Amplification...
α-radioimmunotherapy targeting CD45 may substitute for total-body irradiation in hematopoietic cell transplantation (HCT) preparative regimens lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (mAb; CA12.10C12) protein dose <sup>211</sup>At-radioimmunotherapy, extending analysis include intraorgan <sup>211</sup>At activity distribution and α-imaging–based small-scale dosimetry, along with immunohistochemical staining. <b>Methods:</b> Eight normal dogs were injected either...
We have been investigating two-dimensional (2D) antiscatter grids (2D ASGs) to reduce scatter fluence and improve image quality in cone beam computed tomography (CBCT). In this work, two different aspects of 2D ASGs, their rejection correction capability, were investigated CBCT experiments. To correct residual transmitted through the ASG, it was used as a measurement device with novel method: grid-based sampling.Three focused ASG prototypes grid ratios 8, 12, 16 developed for linac-mounted...
Novel fabrication methods for cost-effective and large-volume production of important lanthanide halide scintillators are currently being explored. Here we report on the growth LaBr :Ce scintillator films in a novel light conserving morphology known as Crystalline Microcolumnar StructureTM (CMSTM), using Hot Wall Evaporation (HWE) technique. This method produces specimens which preserve response uniformity over area film, low attenuation throughout its thickness. Using this approach, have...