A5002592258- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Global Financial Crisis and Policies
- CAR-T cell therapy research
- Health disparities and outcomes
- Global trade and economics
- China's Socioeconomic Reforms and Governance
- Energy, Environment, Economic Growth
- Radiation Dose and Imaging
- Lung Cancer Treatments and Mutations
- Labor market dynamics and wage inequality
- Cancer, Hypoxia, and Metabolism
- Global Health Care Issues
- Climate Change Policy and Economics
- Migration, Ethnicity, and Economy
- Energy, Environment, and Transportation Policies
- Advanced X-ray and CT Imaging
- Economic Sanctions and International Relations
- Radioactive Decay and Measurement Techniques
- Lung Cancer Research Studies
- Economic Theory and Policy
- Radiation Therapy and Dosimetry
- Cuban History and Society
- Natural Resources and Economic Development
University of Wisconsin–Madison
2015-2025
Drexel University
2022-2023
University of Wisconsin Carbone Cancer Center
2022
Peking University
2012
Abstract Purpose/Objective: Radiopharmaceutical therapy (RPT) enables the systemic delivery of an inherently heterogeneous dose radiation. The RPT heterogeneity is created by a tumor’s non-uniform perfusion and variation in target expression. Radiation known to immunomodulate tumor microenvironment (TME) dose-dependent manner. hypothesis that with distribution, delivering low high gradient single TME, will activate multiple dependent immune effects are more effective promoting priming...
Background Systemic radiation treatments that preferentially irradiate cancer cells over normal tissue, known as targeted radionuclide therapy (TRT), have shown significant potential for treating metastatic prostate cancer. Preclinical studies demonstrated the ability of external beam (EBRT) to sensitize tumors T cell checkpoint blockade. Combining TRT approaches with immunotherapy may be more feasible than combining EBRT treat widely disease, however effects on tumor microenvironment alone...
We provide quantitative evidence that the primary effects of economic sanctions on trade and welfare are accompanied by strong extraterritorial — estimates former may be significantly biased if latter not taken into account. Furthermore, while burden falls primarily target countries, corresponding effect among senders third countries is positive. General equilibrium analysis suggests that, for targets, losses due to large exceed reduced with senders. For senders, gains from increased...
Direct measures of the economic impact sanctions are contaminated by endogeneity that arises when other events in target countries (e.g., civil or interstate conflicts, political independence, etc.) instigate imposition sanctions. To address this issue, we propose a novel instrument, sender's aggressiveness, captured number imposed given year. After establishing validity quantify on growth sanctioned states and show that, average, an additional sanction decreases contemporaneous real GDP per...
Abstract Radiopharmaceutical therapies (RPT) activate a type I interferon (IFN1) response in tumor cells. We hypothesized that the timing and amplitude of this varies by isotope. compared equal doses delivered 90 Y, 177 Lu, 225 Ac vitro as unbound radionuclides vivo when chelated to NM600, tumor-selective alkylphosphocholine. Response murine MOC2 head neck carcinoma B78 melanoma was evaluated qPCR flow cytometry. Therapeutic Ac-NM600+anti-CTLA4+anti-PD-L1 immune checkpoint inhibition (ICI)...
Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend survival of patients with OS. Here, we examine dosimetry beagle dogs cross-reactivity human tissues novel antibody, IF3, that targets insulin growth factor receptor type 2 (IGF2R), which overexpressed on OS cells, making it candidate radioimmunotherapy Methods: [89Zr]Zr-DFO-IF3 was injected...
Radiopharmaceutical therapy (RPT) is evolving as a promising strategy for treating cancer. As interest grows in short-range particles, like Auger electrons, understanding the dose–response relationship at deoxyribonucleic acid (DNA) level has become essential. In this study, we used Geant4-DNA toolkit to evaluate DNA damage caused by Auger-electron-emitting isotope I-125. We compared energy deposition and single strand break (SSB) yield each base pair location short B-form (B-DNA) geometry...
Abstract Industry mean wages in C hina have exhibited sharply increased dispersion since the early1990s. Researchers attributed this rising inequality within industrial wage structure to: (i) increasingly competitive labour markets leading to better matches between worker pay, skills and employer demands; or (ii) residual government control some sectors that has generated high through monopoly rent sharing. We argue rise hina's is primarily attributable markets, which led greater returns...
Abstract We provide evidence for the causal impact of social status on longevity by exploiting a natural experiment in which subjects undergo shift their without considerable economic impact. gather data 4190 scientists who were either nominated or successfully elected to Chinese Academy Science Engineering. Being as an academician China is boost (vice‐ministerial level) with negligible direct (US$30 monthly before 2009). After correcting two sources bias, (1) some potential academicians...
We provide quantitative evidence that the primary effects of economic sanctions are accompanied by strong extraterritorial – estimates former may be significantly biased if latter not taken into account. An econometric analysis U.S. embargo on Cuba unveils presence large and significant vary across Cuba’s trade partners also depend direction flows between third countries. During embargo, with most non-sanctioning states decreased, while its allies in close proximity increased. A...
ABSTRACT Background While chimeric antigen receptor (CAR) T cells have achieved significant success against hematological malignancies, efficacy neuroblastoma has been limited. Virus-free CRISPR-edited GD2 TRAC- CAR developed as a potential means of improving but are not curative. Radiopharmaceutical therapy (RPT) is promising approach to enhance the effectiveness immunotherapies, including immune checkpoint inhibitors. However, it remains unclear whether RPT can synergize with improve...
Radiopharmaceutical therapy (RPT) enhances tumor response to immune checkpoint inhibitors (ICI) in preclinical models, but the effects of different radioisotopes have not been thoroughly compared. To evaluate mechanisms RPT+ICI, we used NM600, an alkylphosphocholine selectively taken up by most tumors. Effects 90Y-, 177Lu-, and 225Ac-NM600 + ICIs were compared syngeneic murine B78 melanoma (poorly immunogenic) MC38 colorectal cancer (immunogenic). 90Y-/177Lu-/or delivering 2 Gy mean dose...
Abstract An immunosuppressive tumor microenvironment has hampered the efficacy of immunotherapy in prostate cancer. However, radiation-induced immunological effects can partly mediate anti-tumor by promoting a pro-inflammatory environment potentially responsive to immunotherapy. Herein, we examined immunomodulatory properties radiopharmaceutical therapy (RPT) with NM600 radiolabeled either beta or alpha emitter two cancer models. 225 Ac-NM600, but not 177 Lu-NM600, promoted significant and...
We study the implications of financial-market imperfections on labor and capital misallocation in China. Financial friction stems from private sectors' credit constraints that limit efficient use relative to state firms. Our model can jointly explain flows out into Chinese provinces with high market distortion. To formally test this hypothesis, we propose a measure regional financial based our model. show underlying be inferred by differences-in-differences shares sectors their marginal...
We propose a Generalized Poisson-Pseudo Maximum Likelihood (G-PPML) estimator that relaxes the PPML estimator's assumption dependent variable's conditional variance is proportional to its mean. Instead, we employ an iterated Method of Moments (iGMM) estimate variable directly from data, thus encompassing standard estimators in international trade literature (i.e., PPML, Gamma-PML, and OLS) as special cases. With estimates, GPPML generates coefficient estimates are more efficient robust...
Abstract Background: Sequencing of immune checkpoint inhibitors (ICI) and external beam radiation therapy (EBRT) for cancer treatment has been studied, but the optimal sequencing yet to be determined. While some studies have noted therapeutic advantages priming tumor microenvironment with EBRT prior ICI, others described benefit modulating infiltrating lymphocyte (TIL) population ICI before EBRT. Targeted radionuclide (TRT) approaches allow investigation how irradiation by a tumor-targeted...
Abstract Background: Targeted radionuclide therapy (TRT) delivers radiation treatment systemically to tumor sites via a therapeutic radionuclide-linked tumor-selective targeting vector. NM600 is an alkylphosphocholine analog selectively taken up and retained in murine human cells. We previously showed that low dose delivery with 90Y-NM600 improves response immune checkpoint inhibitors (ICIs). Understanding the effect of different physical properties (emission type, linear energy transfer...
Industry mean wages in China have exhibited sharply increased dispersion since the early 1990, and wage pattern has become increasingly similar to that of developed countries two major emerging economies, Russia Brazil. The upward trend differences average among industry groups parallels increases income inequality throughout Chinese economy. Research on attributed rising market forces leading better matches between worker pay skills; expansion share employment non-government ownership...