A5051413710- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Thyroid Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Radioactive Decay and Measurement Techniques
- Advanced X-ray and CT Imaging
Memorial Sloan Kettering Cancer Center
2022-2025
The University of Sydney
2021-2023
The spatial resolution of emission tomographic imaging systems can lead to a significant underestimation in the apparent radioactivity concentration objects size comparable volume system. aim this study was investigate impact partial effect (PVE) on clinical PET and SPECT with current state-of-the-art instrumentation implications that has for radionuclide dosimetry estimates.Using IEC Image Quality Phantom we have measured observed uptake various sizes both conditions. Both single pixel...
Our aim was to report the use of <sup>64</sup>Cu and <sup>67</sup>Cu as a theranostic pair radionuclides in human subjects. An additional measure whole-organ dosimetry attached somatostatin analog octreotate using sarcophagine MeCOSar chelator (SARTATE) subjects with receptor–expressing lesions confined cranium, thereby permitting normal-organ for remainder body. <b>Methods:</b> Pretreatment PET imaging studies were performed up 24 h after injection [<sup>64</sup>Cu]Cu-SARTATE, estimated...
Accurate quantification in emission tomography is essential for internal radiopharmaceutical therapy dosimetry. Mean activity concentration measurements objects with diameters less than 10 times the full width at half maximum of imaging system's spatial resolution are significantly affected (>10%) by partial-volume effect. This study develops a framework PET and SPECT characterization proposes 2 MIRD recovery coefficient models—a geometric mean approximation (RECOVER-GM) an empirical...
Abstract Background SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due the limited spatial gamma camera. Incorporating modelling (RM) into SPECT reconstruction has been proposed as a possible solution; however, images produced prone noise amplification and Gibbs artefacts. We propose novel approach theranostic setting, which we term SPECTRE (single photon emission computed reconstruction); using diagnostic PET image, with...
<sup>90</sup>Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food Drug Administration–approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based planning. Several different mathematical models are used calculate patient-specific prescribed activity <sup>90</sup>Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, dual compartment (partition). Under auspices...
In nuclear medicine, estimating the number of radioactive decays that occur in a source organ per unit administered activity radiopharmaceutical (i.e., time-integrated coefficient [TIAC]) is an essential task within internal dosimetry workflow. TIAC estimation commonly derived by least-squares fitting various exponential models to time-activity data (radiopharmaceutical biodistribution). Rarely, however, are methods used objectively determine model best characterizes data. Additionally,...
Abstract Positron (β + ) emitting radionuclides have been used for positron emission tomography (PET) imaging in diagnostic medicine since its development the 1950s. Development of a fluorinated glucose analog, fluorodeoxyglucose, labelled with β emitter fluorine-18 ( 18 F-FDG), made it possible to image cellular targets high glycolytic metabolism. These include cancer cells based on increased aerobic metabolism due Warburg effect, and thus, F-FDG is staple nuclear clinics globally. However,...
To investigate and optimize the SPECTRE (Single Photon Emission Computed Theranostic REconstruction) reconstruction approach, using hybrid kernelised expectation maximization (HKEM) algorithm implemented in software for tomographic image (STIR) library, to demonstrate feasibility of performing exploration optimization 2D. Optimal parameters were investigated purpose improving SPECT-based radionuclide therapy (RNT) dosimetry estimates.
In radiopharmaceutical therapy, dosimetry-based treatment planning and response evaluation require accurate estimates of tumor-absorbed dose. Tumor dose are routinely derived using simplistic spherical models, despite the well-established influence tumor geometry on dosimetry. Moreover, degree disease invasiveness correlates with departure from ideal geometry; malignant lesions often possess lobular, spiculated, or otherwise irregular margins in contrast to commonly regular smooth contours...
Potential risk associated with low-dose radiation exposures is often expressed using the effective dose (E) quantity. Other risk-related quantities have been proposed as alternatives. The recently introduced index (RI) shares similarities E but expands metric to incorporate medical imaging-appropriate risks factors including patient-specific size, age, and sex.The aim of this work examine RI for quantifying stochastic demonstrate its applications in nuclear imaging. advantages improved may...