A5012854462- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Radiation Detection and Scintillator Technologies
- Nanoparticle-Based Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Characterization and Applications of Magnetic Nanoparticles
- Atomic and Molecular Physics
- Boron Compounds in Chemistry
- Glioma Diagnosis and Treatment
- Radioactive Decay and Measurement Techniques
- Nanoplatforms for cancer theranostics
- Muon and positron interactions and applications
- Lanthanide and Transition Metal Complexes
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemical Reactions and Isotopes
- Anesthesia and Neurotoxicity Research
- Ultrasound and Hyperthermia Applications
The University of Sydney
2014-2025
Northern Sydney Local Health District
2020
Abstract Detecting glioblastoma infiltration in the brain is challenging due to limited MRI contrast beyond enhancing tumour core. This study aims investigate potential of superparamagnetic iron oxide nanoparticles (SPIONs) as agents for improved detection diffuse cancer. We examine distribution and pharmacokinetics SPIONs models with intact disrupted blood-brain barriers. Using MRI, we imaged RN1-luc U87MG mice injected Gadovist SPIONs, observing differences barrier permeability. Peripheral...
Abstract In cancer radiation therapy, dose enhancement by nanoparticles has to date been investigated only for external beam radiotherapy (EBRT). Here, we report on an in silico study of nanoparticle-enhanced damage the context internal radionuclide therapy. We demonstrate proof-of-principle that clinically relevant radiotherapeutic isotopes (i.e. 213 Bi, 223 Ra, 90 Y, 177 Lu, 67 Cu, 64 Cu and 89 Zr) labeled superparamagnetic iron oxide results enhanced effects localized sub-micron scales....
Abstract Background SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due the limited spatial gamma camera. Incorporating modelling (RM) into SPECT reconstruction has been proposed as a possible solution; however, images produced prone noise amplification and Gibbs artefacts. We propose novel approach theranostic setting, which we term SPECTRE (single photon emission computed reconstruction); using diagnostic PET image, with...
Dose rate variation is a critical factor affecting radionuclide therapy (RNT) efficacy. Relatively few studies to date have investigated the dose effect in RNT. Therefore, aim of this study was benchmark 90Y RNT (at different rates) against external beam radiotherapy (EBRT) vitro and compare cell kill responses between two irradiation processes.Three human colorectal carcinoma (CRC) lines (HT29, HCT116, SW48) were exposed doses ranges 1-10.4 6.2-62.3 Gy with initial rates 0.013-0.13 Gy/hr...
To develop an alpha dosimetry technique for activity calibration of alpha-emitting radiopharmaceuticals using the Gafchromic(®) EBT3 (Gaf-EBT3) radiochromic film (International Speciality product, Wayne, NJ).The Gaf-EBT3 has a tissue equivalent radiosensitive layer (approximately 28 μm) sandwiched between two 100-μm thick polyester sheaths, thereby making it insensitive to particles. We have split sheet surgical scalpel remove one protective layers and covered with thin Mylar(®) foil...
Radium-223 dichloride ((223)Ra) is an alpha particle emitter and a natural bone-seeking radionuclide that currently used for treating osteoblastic bone metastases associated with prostate cancer. The stochastic nature of emission, hits energy deposition poses some challenges estimating radiation damage. In this paper we investigate the distribution to cells by multiple particles corresponding typical clinically delivered dose using Monte Carlo model simulate effects. number were recorded in...
Purpose: This study aimed to develop a chelate-free radiolabeled nanoparticle platform for simultaneous positron emission tomography (PET) and magnetic resonance (MR) imaging that provides contrast-enhanced diagnostic significant image quality gain by integrating the high spatial resolution of MR with sensitivity PET. Methods: A commercially available super-paramagnetic iron oxide (SPION) (Feraheme ® , FH) was labeled [ 89 Zr]Zr using novel radiolabeling technique, heat-induced (HIR)....
The addition of gold nanoparticles within target tissue (i.e. a tumour) to enhance the delivered radiation dose is well studied radiotherapy treatment strategy, despite not yet having been translated into standard clinical practice. While several studies have used Monte Carlo simulations investigate enhancement by Auger electrons emitted from irradiated nanoparticles, none considered effects due escaping fluorescence photons. Geant4 was simulate water phantom containing 10 mg ml-1 uniformly...
Purpose: Using our chelate-free, heat-induced radiolabeling (HIR) method, we show that a wide range of metals, including those with radioactive isotopologues used for diagnostic imaging and radionuclide therapy, bind to the Feraheme (FH) nanoparticle (NP), drug approved treatment iron anemia. Material methods: FH NPs were heated (120°C) nonradioactive resulting metal-FH characterized by inductively coupled plasma mass spectrometry (ICP-MS), dynamic light scattering (DLS), r 1 2 relaxivities...
Abstract Positron (β + ) emitting radionuclides have been used for positron emission tomography (PET) imaging in diagnostic medicine since its development the 1950s. Development of a fluorinated glucose analog, fluorodeoxyglucose, labelled with β emitter fluorine-18 ( 18 F-FDG), made it possible to image cellular targets high glycolytic metabolism. These include cancer cells based on increased aerobic metabolism due Warburg effect, and thus, F-FDG is staple nuclear clinics globally. However,...
We investigate the effects of an increase in production secondary electrons when a β - source commonly used internal radionuclide therapy, 67Cu, is radiolabelled to super-paramagnetic iron oxide nanoparticle (SPION), with specific emphasis on role SPION cluster size and geometry. A positive relationship found between degree which nanoparticles are clustered associated radio-enhancement effects, population playing major role, as well separation within distance clusters. Our simulation results...
Abstract In positron emission tomography (PET), the finite range over which positrons travel before annihilating with an electron places a fundamental physical limit on spatial resolution of PET images. After annihilation, photon pair detected by instrumentation is emitted from location that different positron-emitting source, resulting in image blurring. Here, we report localization range, and hence annihilation quanta, strong nanoscale magnetization superparamagnetic iron oxide...
Abstract Background The prediction of response is one the major challenges in radiation-based therapies. Although selection accurate linear–quadratic model parameters essential for estimation radiation and treatment outcome, there a limited knowledge about these radiobiological liver tumours using radionuclide treatments. Methods “clinical radiobiological” ( $$T_{{\text{p}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>T</mml:mi> <mml:mtext>p</mml:mtext>...
Monte Carlo radiation transport models are increasingly being used to simulate biological damage. However, such biophysics simulations require realistic molecular for water, whereas existing limited by their use of atomic cross-sections, which become inadequate accurately modelling interactions the very low-energy electrons that responsible In this study, we borrow theoretical methods commonly employed in dynamics model wavefunction water molecule as first step towards deriving new...