A5081063387- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Barrier Structure and Function Studies
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Coral and Marine Ecosystems Studies
- Radiation Therapy and Dosimetry
- Histone Deacetylase Inhibitors Research
- Radiopharmaceutical Chemistry and Applications
- Chemical Reactions and Mechanisms
- Prostate Cancer Treatment and Research
- Marine Biology and Ecology Research
- Organic Chemistry Cycloaddition Reactions
- Advanced X-ray and CT Imaging
- Veterinary Oncology Research
- Cancer Cells and Metastasis
- Atmospheric Ozone and Climate
- Characterization and Applications of Magnetic Nanoparticles
- Molecular Spectroscopy and Structure
- Structural and Chemical Analysis of Organic and Inorganic Compounds
The University of Sydney
2022-2025
Ingham Institute
2022-2023
Migration Institute of Australia
2022
The University of Queensland
2018-2021
Imperial College London
2014-2016
Abstract The reactive oxygen species superoxide (O 2 ·− ) is both beneficial and detrimental to life. Within corals, may contribute pathogen resistance but also bleaching, the loss of essential algal symbionts. Yet, role in coral health physiology not completely understood owing a lack direct situ observations. By conducting field measurements produced by corals during bleaching event, we show substantial species-specific variation external levels, which reflect balance production...
Abstract Detecting glioblastoma infiltration in the brain is challenging due to limited MRI contrast beyond enhancing tumour core. This study aims investigate potential of superparamagnetic iron oxide nanoparticles (SPIONs) as agents for improved detection diffuse cancer. We examine distribution and pharmacokinetics SPIONs models with intact disrupted blood-brain barriers. Using MRI, we imaged RN1-luc U87MG mice injected Gadovist SPIONs, observing differences barrier permeability. Peripheral...
The clinical translation of new nanoparticle-based therapies for high-grade glioma (HGG) remains extremely poor. This has partly been due to the lack suitable preclinical mouse models capable replicating complex characteristics recurrent HGG (rHGG), namely heterogeneous structural and functional blood-brain barrier (BBB). goal this study is compare tumor BBB rHGG with two different HGG, ubiquitously used U87 cell line xenograft model a patient-derived WK1 model, in order assess their...
The reactive oxygen species (ROS) superoxide has been implicated in both beneficial and detrimental processes coral biology, ranging from pathogenic disease resistance to bleaching. Despite the critical role of ROS health, there is a distinct lack measurements thus an incomplete understanding underpinning sources production mechanisms within systems. Here, we quantified situ extracellular concentrations at surfaces aquaria-hosted Porites astreoides during diel cycle. High (~10's nM) were...
High-grade glioma (HGG) remains a recalcitrant clinical problem despite many decades of research. A major challenge in improving prognosis is the inability current therapeutic strategies to address clinically significant burden infiltrating tumor cells that extend beyond margins primary mass. Such cannot be surgically excised nor efficiently targeted by radiation therapy. Therapeutic targeting this cell population significantly hampered presence an intact blood-brain barrier (BBB). In study,...
The aim of this prospective clinical study was to evaluate the potential prostate specific membrane antigen (PSMA) targeting ligand, [68Ga]-PSMA-Glu-NH-CO-NH-Lys-2-naphthyl-L-Ala-cyclohexane-DOTA ([68Ga]Ga-PSMA-617) as a positron emission tomography (PET) imaging biomarker in recurrent glioblastoma patients. Patients underwent [68Ga]Ga-PSMA-617 and O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET) PET scans on two separate days. tumour selectivity assessed by comparing volume delineation...
Novel targeted therapies for children diagnosed with medulloblastoma (MB), the most common malignant pediatric brain tumor, are urgently required. A major hurdle in development of effective is impaired delivery systemic to tumor cells due a specialized endothelial blood-brain barrier (BBB). Accordingly, integrity BBB an essential consideration any preclinical model used assessing novel therapeutics. This study sought assess functional several mouse models MB.Dynamic contrast enhancement...
Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality morbidity. Existing treatment protocols are aggressive in nature resulting significant neurological, intellectual physical disabilities for children undergoing treatment. Thus, there an urgent need improved, targeted therapies that minimize these harmful side effects. We identified candidate drugs MB using network-based systems-pharmacogenomics approach: based on results...
New technologies developed to improve survival outcomes for glioblastoma (GBM) continue have limited success. Recently, image-guided dose painting (DP) radiotherapy has emerged as a promising strategy increase local control rates. In this study, we evaluate the practical application of multiparametric MRI model glioma infiltration DP in GBM by measuring its conformity, feasibility, and expected clinical benefits against standard care treatment.Maps tumor probability were generated from...
Multicentre clinical trials evaluating the role of 18F-Fluoroethyl-L-tyrosine (18F-FET) PET as a diagnostic biomarker in glioma management have highlighted need for standardised methods data analysis. 18F-FET uptake normalised against background contralateral brain is standard imaging technique to delineate biological tumour volume (BTV). Quantitative analysis images requires consistent and robust activity. Currently, defining activity involves manual selection an arbitrary region interest,...
Glioblastoma (GBM) patients have a dismal prognosis. Tumours typically recur within months of surgical resection and post-operative chemoradiation. Multiparametric magnetic resonance imaging (mpMRI) biomarkers promise to improve GBM outcomes by identifying likely regions infiltrative tumour in probability (TP) maps. These could be treated with escalated dose via dose-painting radiotherapy achieve higher rates control. Crucial the technical validation using is repeatability derived...
Introduction Distinguishing meningiomas from other intracranial neoplasms is clinically relevant as the prognostic and therapeutic implications differ greatly influence clinical decision making. Dynamic contrast-enhanced MRI (DCE-MRI) an imaging technique that assists with characterisation of physiologic alterations such blood flow tissue vascular permeability. Quantitative pharmacokinetic analysis utilising DCE-MRI has not been studied in canine neuro-oncology. Methods A retrospective study...
Motivation: A quantitative MRI (qMRI) protocol was developed for a clinical study aimed at identifying regions of tumour hypoxia in glioblastoma patients. Technical validation qMRI biomarkers requires thorough testing the against reference standards. Goal(s): To assess and report accuracy, repeatability, reproducibility protocol. Approach: Test-retest scans NIST systems phantom were acquired on two 3T MAGNETOM VIDA scanners. Accuracy, repeatability T1, T2 maps, calibrated T1 maps from...
Background Glioblastoma (GBM) is the most aggressive type of brain cancer, with a 5-year survival rate ~5% and tumours recurring locally within months first-line treatment. Hypoxia associated worse clinical outcomes in GBM, as it leads to localized resistance radiotherapy subsequent tumour recurrence. Current standard care treatment does not account for hypoxia, due challenges mapping hypoxia routine practice. In this study, we aim investigate role oxygen enhanced (OE) blood-oxygen level...
Abstract Local recurrence in glioblastoma (GBM) patients is caused by the ability of tumour cells to develop treatment resistance mechanisms. Hypoxia, which present subregions GBM tumours, leading cause radiotherapy and associated with worse clinical outcomes GBM. Current standard care does not account for hypoxia. The image hypoxia at various stages offers opportunities personalise improve patients. Preoperative imaging opportunity supramarginal resections surgical planning beyond current...