A5027931071- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Neuroscience and Neuropharmacology Research
- Pleural and Pulmonary Diseases
- RNA Research and Splicing
- Antifungal resistance and susceptibility
- Emergency and Acute Care Studies
- Meningioma and schwannoma management
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Fungal Infections and Studies
- Cardiac Imaging and Diagnostics
- T-cell and B-cell Immunology
- Microtubule and mitosis dynamics
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Management of metastatic bone disease
- Liver Disease and Transplantation
- Nonmelanoma Skin Cancer Studies
- Respiratory viral infections research
Université de Tours
2022-2025
Centre Hospitalier Universitaire de Tours
2022-2025
The University of Queensland
2015-2024
Thion Medical (France)
2023
Princess Alexandra Hospital
2020-2023
Société Française de Cardiologie
2023
Queensland Cyber Infrastructure Foundation
2021
Centre d'Etudes et De Recherche en Informatique et Communications
2012-2014
CHU Dijon Bourgogne
2012
Université de Lille
2012
We demonstrate here that the CD44 molecule, which mediates lymphocyte adhesion to high endothelial venules (HEV), is also involved in delivery of an activation signal T cell. have produced a mAb (H90) able block binding lymphocytes venules. H90 had no effect on [3H]TdR incorporation whole PBL stimulated by lectins, allogeneic cells, or CD3 soluble phase; contrast, it strongly increased CD2 pairs linked plastic culture plates, when purified cells were used, could efficiently induce them...
Binding monoclonal antibodies (MAb) both to D66 and 9.6/T11(1) epitopes on the CD2 [T,gp50]-defined molecule produces a high level of T cell mitosis. This was observed with battery MAb different isotypes. In contrast, none anti-D66 or anti-9.6/T11(1)Ab could trigger proliferation in combination anti-T11(3). Moreover, all anti-D66-9.6/T11(1) pairs tested required monocytes activate cells which were recruited through their Fc receptors. Variations among normal individuals response Ab, 75%...
Monoclonal antibody (MAb) GT2 defines a unique epitope on the CD2 molecule. triggers T cell mitosis in combination with any MAb directed against 9.6/T11(1) or D66, two previously defined epitopes. We have shown already that accessory cells (AC) are required for plenary T-PBL activation by pair of Ab D66 + 9.6/T11(1). In this study, we further investigated their role and found it to vary anti-CD2 used. When purified preparation is used, level [3H]TdR incorporation observed anti-(GT2...
Noninvasive serum biomarkers (nonalcoholic fatty liver disease fibrosis score [NFS], 4 [FIB-4], or enhanced [ELF] test) are recommended as first-line tools to determine the risk of advanced in nonalcoholic disease. We aimed assess utility a pragmatic approach screening for clinically significant primary care and diabetes clinics. recruited 252 patients from an endocrine clinic facility. Anthropometric measurements, ELF test, ultrasound, stiffness measurements (LSMs) were performed....
Abstract Kainate (KA) is a potent neuroexcitatory agent in several areas of the adult brain, with convulsant and excitotoxic properties that increase as ontogeny proceeds. Besides its depolarizing actions, KA may enhance intracellular accumulation Ca 2+ to promote selective neuronal damage. The effects are mediated by specific receptors recently considered be involved fast neurotransmission can activated synaptically. receptors, e.g. GluR5 GluR6 have been characterized molecular cloning....
Abstract The zygosity of 19 colorectal carcinomas (either near‐diploid or polyploid) from patients known to be heterozygous for RFLPs located on chromosome 18 the short arm 17 has been examined. In most cases, at least one allele was significantly under‐represented. reason absence complete loss heterozygosity investigated 5 polyploid tumors. It shown that diploid component which, in these tumors, is essentially composed non‐neoplastic cells, remains as invariably loses heterozygotity....
A thorough understanding of local and contemporary invasive fungal infection (IFI) epidemiology in immunocompromised children is required to provide a rationale for targeted prevention treatment strategies.Retrospective data over 10 years from four tertiary pediatric oncology hematopoietic stem cell transplant (HSCT) units across Australia were analyzed report demographic, clinical, mycological characteristics IFI episodes, crude prevalence select oncology/HSCT groups. Kaplan-Meier survival...
Invasive fungal infections (IFI) are an important complication of acute lymphoblastic leukaemia (ALL) treatment. Our study describes the prevalence and outcomes IFI in children with ALL.IFI episodes primary or relapsed ALL, identified for The Epidemiology Risk Factors Fungal Infections Immunocompromised Children study, were analysed. classified according to European Organization Research Treatment Cancer/Invasive Cooperative Group criteria a 'modified-possible' category included.A total 123...
The objectives of this study were to investigate health care utilization costs patients with video-electroencephalography (VEEG)-confirmed functional seizures (FS), determine whether who received a satisfactory neurologic disorder (FND) diagnosis explanation had reduced compared those poor explanation; and quantify the overall 2 years prediagnosis postdiagnosis for receiving different explanation.
Abstract Aims to explore the value of dobutamine stress-echocardiography (DSE) identify severe aortic stenosis (AS) in patients with discordant low-gradient AS and preserved left ventricular ejection fraction (LVEF>50%). Methods Among 52 (age 79±7 years; males 46%, mean gradient: 31±5 mmHg) low gradient LVEF prospectively enrolled ROTAS trial, 42 underwent both DSE CT calcium score. An score > 1200 AU women 2000 men was used as a referral limit AS. The Youden method best...
Abstract Introduction Distress related to wearing an immobilisation mask for radiotherapy treatment (RT) is a common experience the person undergoing RT head and neck cancer (HNC). Described as ‘mask anxiety’, there little known about patterns of this distress through course or what strategies are being used by people help alleviate anxiety. Methods The study prospective cohort design examine patient–reported anxiety during RT, using modified Thermometer (DT) survey explore patients assist...
The NR1 and NR2 subunits of the N-methyl-D-aspartate (NMDA) receptor are encoded by distinct genes. In rat brain, four C-terminal variants subunit (NR1-1 to NR1-4) a single gene, generated alternative splicing C1 C2 exon cassettes, while different genes encode (NR2 A-D). Functional NMDA receptors result from heteromultimeric assembly with subunits. NR2B interacts post-synaptic density protein 95 (PSD-95), SAP97 members membrane-associated guanylate-like kinase (MAGUK) family proteins. This...
Abstract Introduction Palliative radiotherapy is effective in reducing symptom burden and improving quality of life patients with symptomatic metastatic cancer should be delivered a timely manner. The aim this study was to determine whether referring directly Advanced Practice Radiation Therapist ( APRT ) improves access palliative reduces time from referral treatment. Methods At Oncology Mater Center ROMC Brisbane, Australia new pathway developed which involved requiring radiotherapy, being...
Background The characteristics of mature contemporary rapid response systems are unclear. Aim To determine the patient characteristics, processes and outcomes, both in‐hospital post‐discharge, a well‐established system in tertiary adult hospital. Methods This is prospective study consecutive team ( RRT ) activations between 1 July 25 November 2015. Variables included timing, location triggers activations, interventions undertaken, mortality readmission status at 28 days post‐discharge....
Physical exercise may reduce dementia risk in aging, but varying reports on its effectiveness make it challenging to ascribe what level of will have significant longer-term effects important functions such as hippocampal-based learning and memory. This study compared the effect three different 6-month regimens hippocampal-dependent cognition healthy, elderly individuals. Participants, aged 65-85 with no cognitive deficits, were randomly assigned one interventions (low (LIT), medium (MIT),...
Src-mediated tyrosine phosphorylation of<i>N</i>-methyl-d-aspartate receptor subunits has been shown to modify the functional properties receptors. Moreover, calpain-mediated truncation found alter structure of In present study, we first used immunoprecipitation with a variety antibodies against<i>N</i>-methyl-d-aspartate and anti-phosphotyrosine show that tyrosine-phosphorylated <i>N</i>-methyl-d-aspartate are protected against their C-terminal domains. A GST fusion protein containing...
Abstract Introduction For gynaecological cancers, volumetric modulated arc therapy (VMAT) offers comparable plan quality with shorter treatment delivery times when compared to intensity radiation (IMRT). Methods The clinical IMRT plans of twenty cancer patients were a retrospectively generated VMAT plan. Planning target volume (PTV) metrics D95 > 99%, homogeneity index, and conformity index. Organs at risk (OAR) doses bladder V45 < 35%, bowel V40 30%, femoral head neck (FHN) V30 50%,...
Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult leukemia, an aggressive lymphoproliferative disorder, and chronic neurological diseases. In vitro it can infect several types of cells but transforms only human T lymphocytes. We have previously shown that HTLV-I viral particles, even when noninfectious, were able to activate resting lymphocytes, suggesting this activation step may be important in the initiation process. present study, we first demonstrate...
Abstract Introduction The purpose of the study was to evaluate palliative advanced practice radiation therapy ( APRT ) role with respect impact on waiting times for patients from referral treatment delivery, ability define fields and patient satisfaction. evaluation pathway has been previously published. Methods Patients were allocated two different pathways; standard. in had their radiotherapy managed by including defining blinded oncologist RO ). Results Of 150 patients, 94 56 through...