A5087222566- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Global Cancer Incidence and Screening
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Multiple Sclerosis Research Studies
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Screening and Detection
- Hepatitis C virus research
- Global Health Workforce Issues
- Cancer survivorship and care
- Cystic Fibrosis Research Advances
- Cervical Cancer and HPV Research
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Primary Care and Health Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Policy and Management
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Indigenous Health, Education, and Rights
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory and Cough-Related Research
QIMR Berghofer Medical Research Institute
2016-2025
The University of Queensland
2015-2024
Translational Research Institute
2017-2024
Mater Research
2021
University of Tasmania
2009-2021
Charles Darwin University
2011-2020
Menzies School of Health Research
2011-2020
Cancer Council Queensland
2011-2018
National Health and Medical Research Council
2017-2018
Australian Research Council
2018
Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), second leading cause cancer death worldwide. We comprehensively examined recent international trends primary and HCC incidence using population‐based registry data. Incidence for all by calendar time birth cohort was selected countries between 1978 2012. For each successive 5‐year period, age‐standardized rates were calculated from Volumes V to XI Cancer in Five Continents (CI5) series online electronic...
<h3>Objectives:</h3> To examine whether past and recent sun exposure vitamin D status (serum 25-hydroxyvitamin [25(OH)D] levels) are associated with risk of first demyelinating events (FDEs) to evaluate the contribution these factors latitudinal gradient in FDE incidence Australia. <h3>Methods:</h3> This was a multicenter incident case-control study. Cases (n = 216) were aged 18–59 years resident within one 4 Australian centers (from latitudes 27°S 43°S), from November 1, 2003, December 31,...
Primary liver cancer, the most common histologic types of which are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is second leading cause cancer death worldwide. While rising incidence in low‐risk areas decreasing some high‐risk has been reported, trends have not thoroughly explored by country or type. We examined overall histology calendar time birth cohort for selected countries between 1978 2007. For each successive 5‐year period, age‐standardized rates were...
Primary liver cancer (PLC) is the sixth most common worldwide and second cause of death. Future predictions can inform health planners raise awareness need for control action. We predicted future burden PLC in 30 countries around 2030. Incident cases ( International Classification Diseases , Tenth Revision, C22) were obtained from 1993‐2007. projected new to 2030 using age‐period‐cohort models (NORDPRED software). Age‐standardized incidence rates per 100,000 person‐years calculated by...
There are few population-based childhood cancer registries in the world containing stage and treatment data. Data from Australian Paediatric Cancer Registry were used to calculate incidence rates during most recent 10-year period (1997–2006) trends between 1983 2006 for 12 major diagnostic groups of International Classification Childhood Cancer. In 1997–2006, there 6184 (at 0–14 years) cases Australia (157 per million children). The commonest cancers leukaemia (34%), that central nervous...
<h3>Objective:</h3> To examine the association between past pregnancy, offspring number, and first clinical demyelination risk. <h3>Methods:</h3> Cases (n = 282) were aged 18–59 years with a diagnosis of CNS (first demyelinating event [FCD]) resident within 1 4 Australian centers (from latitudes 27° south to 43° south) from 2003 2006. Controls 542) matched cases on age, sex, study region, without demyelination. <h3>Results:</h3> Higher number was associated FCD risk among women (<i>p</i>...
Objective Indigenous children in developed countries are at increased risk of chronic suppurative lung disease (CSLD), including bronchiectasis. We evaluated sociodemographic and medical factors indigenous with CSLD/bronchiectasis from Australia, United States (US), New Zealand (NZ). Methods aged 0.5–8 years were enrolled specialist clinics Australia (n = 97), Alaska 41), NZ 42) during 2004–2009, followed for 1–5 years. Research staff administered standardized parent interviews, reviewed...
Objective Health-related stigma is associated with negative psychological and quality of life outcomes in lung cancer patients. This study describes the impact on patients' distress explores role social constraints illness appraisal as mediators effect. Methods A self-administered cross-sectional survey examined 151 people (59% response rate) diagnosed from Queensland New South Wales. stigma, appraisals were assessed predictors adjustment outcomes. Results Forty-nine percent patients...
Abstract Background Non‐alcoholic fatty liver disease (NAFLD) is a common cause of incidental test abnormalities. General practitioners (GP) have key role in identifying people with NAFLD at risk significant disease. Recent specialist guidelines emphasise the use fibrosis algorithms or serum biomarkers rather than routine tests, to assess advanced fibrosis. Aim To evaluate primary care clinicians’ current approach diagnosis, management and referral NAFLD. Methods A cross‐sectional survey...
Background: There is contradictory evidence for a role of dietary fat in risk multiple sclerosis (MS). Objectives: To examine the association between usual intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) first clinical diagnosis CNS demyelination (FCD). Methods: Multi-centre incident case-control study four regions Australia during 2003–2006. Cases were aged 18–59 years had FCD; controls matched to case on age, sex location. Dietary data...
Increasing prevalence and variable geographic patterns of occurrence multiple sclerosis suggest an environmental role in causation. There are few descriptive, population-level, data on whether such variability applies to first demyelinating events (FDEs). We recruited 216 adults (18—59 years), with a FDE between 1 November 2003 31 December 2006 multi-center incident case-control study four locations the south-eastern eastern seaboard Australia, spanning latitudes 27° south 43° south....
To cite this article: Hughes AM, Lucas RM, Ponsonby A‐L, Chapman C, Coulthard A, Dear K, Dwyer T, Kilpatrick TJ, McMichael AJ, Pender MP, Taylor BV, Valery P, van der Mei IAF, Williams D. The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma hayfever: an Australian multicenter study. Pediatr Allergy Immunol 2011; 22 : 327–333. Abstract Observations increasing allergy prevalence with decreasing distance from the Equator positive associations ambient have...
Townsville Cancer Centre provides video-consultation (VC) services to patients in rural/remote regions of North Queensland order improve access specialist cancer care. The experience and responses indigenous using this service have not been studied. Our objective is assess the level satisfaction Indigenous patients, their families health workers (HWs) VC such teleoncology service.
Indigenous Australians have lower overall cancer survival which has not yet been fully explained. To address this knowledge deficit, we investigated the associations between comorbidities, treatment and in non-Indigenous people Queensland, Australia.
Aim: We examined the combined effect of having multiple key risk factors and interactions between sclerosis (MS). Methods: performed an incident case-control study including cases with a first clinical diagnosis central nervous system demyelination (FCD) population-based controls. Results: Compared to those without any factors, one, two, three, four or five had increased odds being FCD case 2.12 (95% confidence interval (CI), 1.11–4.03), 4.31 CI, 2.24–8.31), 7.96 3.84–16.49), 21.24...
Noninvasive serum biomarkers (nonalcoholic fatty liver disease fibrosis score [NFS], 4 [FIB-4], or enhanced [ELF] test) are recommended as first-line tools to determine the risk of advanced in nonalcoholic disease. We aimed assess utility a pragmatic approach screening for clinically significant primary care and diabetes clinics. recruited 252 patients from an endocrine clinic facility. Anthropometric measurements, ELF test, ultrasound, stiffness measurements (LSMs) were performed....
Patient-centred care, increasingly highlighted in healthcare strategies, necessitates understanding public preferences for service attributes. We aimed to understand the of Australian population regarding attributes chronic disease screening programmes. The were elicited using discrete choice experiment (DCE) methodology. A DCE was administered a sample general population. Respondents asked make choices, each offering two hypothetical scenarios defined by conduct, quality and accuracy test...
The causes of cutaneous melanoma among children under 15 years are largely unknown. We report the findings an epidemiological study childhood in Queensland, Australia, which has highest incidence rates world. All 61 cases less than notified to Queensland Cancer Registry 1987–1994 were eligible participate a population-based, case-control study. Data collected through structured, face-to-face interviews with parents and skin examinations 52 participating 156 age-and sex-matched controls....