A5063907536- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Iron Metabolism and Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diabetes Management and Research
- Mitochondrial Function and Pathology
- Clinical Laboratory Practices and Quality Control
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dialysis and Renal Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Genetic and Kidney Cyst Diseases
- Analytical Chemistry and Chromatography
- Trace Elements in Health
- Prion Diseases and Protein Misfolding
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metabolism, Diabetes, and Cancer
- Anesthesia and Neurotoxicity Research
- Prostate Cancer Treatment and Research
- Vitamin D Research Studies
- Electrolyte and hormonal disorders
Princess Alexandra Hospital
2012-2024
Queensland Health
2017-2020
National Health and Medical Research Council
2017
The University of Queensland
1990-2017
Westmead Hospital
2015
Royal Brisbane and Women's Hospital
1989-1992
Natural Sciences and Engineering Research Council
1985
Abstract We measured by different techniques the ferritin concentration in serum two large asymptomatic Australian population samples: 1367 bank employees and 601 insurance corporation employees. Ethanol intake, diet, frequency of blood donation, smoking exercise habits, past medical history were documented. The median varied according to age sex, but was generally higher than previously reported populations under 65 years. Results for samples close agreement. Apart from donation status,...
Summary We determined the prevalence of iron overload due to homozygous haemochromatosis in an asymptomatic Australian (predominantly Caucasian) population by surveying 1968 employees two large corporations. Subjects were screened measurement transferrin saturation and serum ferritin concentration and, all subjects with elevation both indices, percutaneous liver biopsy was performed establish whether significant present. The this 0·36%. rate not significantly different between males females,...
Abstract Background Non‐alcoholic fatty liver disease (NAFLD) is a common cause of incidental test abnormalities. General practitioners (GP) have key role in identifying people with NAFLD at risk significant disease. Recent specialist guidelines emphasise the use fibrosis algorithms or serum biomarkers rather than routine tests, to assess advanced fibrosis. Aim To evaluate primary care clinicians’ current approach diagnosis, management and referral NAFLD. Methods A cross‐sectional survey...
Noninvasive serum biomarkers (nonalcoholic fatty liver disease fibrosis score [NFS], 4 [FIB-4], or enhanced [ELF] test) are recommended as first-line tools to determine the risk of advanced in nonalcoholic disease. We aimed assess utility a pragmatic approach screening for clinically significant primary care and diabetes clinics. recruited 252 patients from an endocrine clinic facility. Anthropometric measurements, ELF test, ultrasound, stiffness measurements (LSMs) were performed....
An observational study describing the number and type of chronic conditions medications taken by diabetic patients with NAFLD identifying characteristics that may impact liver disease severity or clinical management. Adults 2 diabetes have a high prevalence nonalcoholic fatty (NAFLD) increased risk developing advanced disease. Appropriate management should consider population, as comorbid increase complexity treatment strategies. Diabetic at clinically significant (as assessed FIB-4 fibrosis...
Glucose is one of the most frequently measured analytes in laboratories. Most recent studies on glucose stabilities confirm that sodium fluoride/potassium oxalate (NaF/KOx) tube far from gold standard. Citrate tubes have been suggested as preferred type by many institutions. Greiner has introduced a glucose-specific (Glucomedics) containing NaF/KOx, citrate, and EDTA to minimise glycolysis. The aim was determine which would be suitable for accurate estimation routine laboratory setting.The...
Acute kidney injury (AKI) is common in dogs. Few studies have assessed sequential changes indices of function dogs with naturally occurring AKI.To document conventional renal function, to better define the course AKI, and identify a candidate marker for recovery.Ten AKI.Dogs were prospectively enrolled divided into surviving nonsurviving Urine production was measured closed system 7 days. One 24-hour urinary clearances performed daily estimate solute excretion glomerular filtration rate...
A 19 year old male with phenylketonuria (PKU) developed a spastic paparesis 8 months after stopping his restricted phenylalanine diet. CT and MRI showed abnormalities of the deep cerebral white matter, visual evoked response latencies were prolonged. The spasticity gradually improved over several resuming PKU repeat scan was unchanged. His brother also had ceased dietary restrictions, but only neurological abnormality slight increase in tendon reflexes lower limbs. brain normal. DNA analysis...
Aim . To examine the association between lifetime alcohol consumption and significant liver disease in type 2 diabetic patients with NAFLD. Methods A cross-sectional study assessing 151 NAFLD at risk of clinically disease. fibrosis severity was classified by transient elastography; stiffness measurements ≥8.2 kPa defined fibrosis. Lifetime drinking history into nondrinkers, light drinkers (always ≤20 g/day), moderate (any period intake >20 g/day). Result Compared were more likely to be...
A patient who ingested a methanol/nitromethane mixture (model airplane fuel) showed an apparent plasma creatinine concentration of 8.0 mmol/L by the Jaffé reaction when actual concentration, as measured specific enzymatic method, was 0.09 mmol/L. This effect due to nitromethane in plasma. Interference with determination alkaline picrate (the reaction) has not previously been reported. When added plasma, linearly related amount added. Comparison spectral changes occurring during...
Background Availability of whole blood creatinine estimation for patients scheduled to undergo radiological contrast investigations can provide information aid patient care by reducing adverse effects and improving departmental efficiencies. Methods We performed imprecision studies, different sample type comparison in 40 participants, a limited interference study with dopamine dobutamine on the i-Stat StatStrip point-of-care enzymatic analysers Beckman DxC800 Jaffe assay. Results Imprecision...
Current commercial tubes have difficulties in producing "true" serum from all blood samples even within the recommended clotting times. Hence, Becton Dickinson (BD) and now Greiner produced containing thrombin as procoagulant to reduce time increase possibility of anticoagulated samples.The BCA Fast Clot (GBBCAFC) tube was evaluated a hospital environment using 40 participants, (30 healthy 10 undergoing renal dialysis) for 32 analytes against lithium heparin BD Rapid Serum Tubes (BD RST)...
Introduction: Gentamicin due to its low level of resistance and rapid bactericidal activity is commonly used treat gram-negative bacteria. However, toxic effects it needs be monitored. To date, no interference has been reported with gentamicin assays.