Florent Le Ven

ORCID: 0000-0003-0555-1816
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About
Contact & Profiles
Research Areas
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Function and Risk Factors
  • Cardiac Imaging and Diagnostics
  • Infective Endocarditis Diagnosis and Management
  • Cardiac Structural Anomalies and Repair
  • Cardiac, Anesthesia and Surgical Outcomes
  • Atrial Fibrillation Management and Outcomes
  • Aortic Disease and Treatment Approaches
  • Advanced MRI Techniques and Applications
  • Cardiomyopathy and Myosin Studies
  • Venous Thromboembolism Diagnosis and Management
  • Ultrasound in Clinical Applications
  • Pulmonary Hypertension Research and Treatments
  • Cardiovascular Disease and Adiposity
  • Cardiac pacing and defibrillation studies
  • Antimicrobial Resistance in Staphylococcus
  • Acute Ischemic Stroke Management
  • Cardiac Arrhythmias and Treatments
  • Cardiac tumors and thrombi
  • Cerebrovascular and Carotid Artery Diseases
  • Aortic aneurysm repair treatments
  • Coronary Interventions and Diagnostics
  • Pericarditis and Cardiac Tamponade
  • Congenital Heart Disease Studies
  • Pharmacology and Obesity Treatment

Université de Bretagne Occidentale
2012-2025

Centre Hospitalier Régional Universitaire de Brest
2012-2025

Inserm
2022-2025

Hôpital Maison Blanche
2012-2024

University Hospital Complex Of Vigo
2022

European Organisation for Rare Diseases
2022

Centre Hospitalier Universitaire de Bordeaux
2022

Umeå University
2020

Société Française de Cardiologie
2016-2019

Université Laval
2013-2018

In 1998 we estimated the incidence of venous thromboembolism (VTE) to be 1.8/1,000 per year. The aim this study was compare current VTE that observed in 1998. We prospectively recorded all cases symptomatic pulmonary embolism (PE) and deep vein thrombosis (DVT) lower limbs diagnosed between March 1, 2013 February 28, 2014 hospitals community, using same method geographic area than rates were computed compared with those age- sex-specific standardised ratios (SIRs). 2013, 576 (279 isolated...

10.1160/th16-03-0205 article EN Thrombosis and Haemostasis 2016-07-28

Importance Correction of tricuspid regurgitation using transcatheter edge-to-edge repair (T-TEER) in addition to guideline-directed optimized medical therapy (OMT) may improve clinical outcomes. Objective To evaluate the efficacy T-TEER + OMT vs alone patients with severe, symptomatic regurgitation. Design, Setting, and Participants Investigator-initiated, prospective, randomized (1:1) trial evaluating adult The was conducted at 24 centers France Belgium (March 2021 March 2023; latest...

10.1001/jama.2024.21189 article EN JAMA 2024-11-27

<h3>Background</h3> The transthoracic echocardiographic (TTE) evaluation of the severity residual aortic regurgitation (AR) following transcatheter valve implantation (TAVI) has been controversial and lacks validation. <h3>Objectives</h3> This study sought to compare TTE cardiac magnetic resonance (CMR) for assessment AR in patients undergoing TAVI with a balloon-expandable valve. <h3>Methods</h3> CMR exams were performed pre-TAVI 50 repeated postprocedure 42 patients. All imaging data...

10.1136/heartjnl-2014-305615 article EN Heart 2014-08-14

<h3>Objective</h3> The study purpose was to assess the usefulness of echocardiographic parameters aortic stenosis (AS) severity and left ventricular (LV) systolic function predict mortality in AS. main hypothesis is that LV are most important independent predictors mortality, whereas not. <h3>Methods</h3> 1065 consecutive patients with AS referred echocardiography laboratory meeting inclusion/exclusion criteria were included followed during 5.7 years. end points valve replacement (AVR)...

10.1136/heartjnl-2015-308742 article EN Heart 2016-04-05

<h3>Importance</h3> In low-flow, low-gradient aortic stenosis (LFLG AS), the severity of left ventricular dysfunction remains a key factor in evaluation valve replacement. <h3>Objective</h3> To evaluate clinical outcomes and changes ejection fraction (LVEF) after transcatheter replacement (TAVR) patients with LFLG AS severe dysfunction. <h3>Design, Setting, Participants</h3> This multicenter registry is substudy True or Pseudo-Severe Aortic Stenosis–TAVI that included classic AS, defined as...

10.1001/jamacardio.2018.4320 article EN JAMA Cardiology 2018-12-19

The objective of this study was to examine the association between different patterns left ventricular (LV) remodelling/hypertrophy on all-cause and cardiovascular mortality in patients with aortic stenosis (AS).In total, 747 consecutive (69 ± 14 years, 57% men) AS preserved LV ejection fraction were included study. According mass index relative wall thickness, classified into four patterns: normal, concentric remodelling (CR), hypertrophy (CH), eccentric (EH). One hundred sixteen (15%) had...

10.1093/ehjci/jew288 article EN European Heart Journal - Cardiovascular Imaging 2016-11-04

Assessment of cardiac anatomy and function by cardiovascular magnetic resonance (CMR) is accurate reproducible commonly performed to clarify borderline results obtained other techniques. Normal reference values are lacking in a large sample young healthy adults. As CMR increasingly solicited discriminate normality from equivocal disease this population, we sought determine reliable values.A 434 Caucasian adults aged 26 ± 4 years (45% male) without or risk factors (including obesity smoking)...

10.1093/ehjci/jev217 article EN European Heart Journal - Cardiovascular Imaging 2015-09-09

Abstract Aims to explore the value of dobutamine stress-echocardiography (DSE) identify severe aortic stenosis (AS) in patients with discordant low-gradient AS and preserved left ventricular ejection fraction (LVEF&amp;gt;50%). Methods Among 52 (age 79±7 years; males 46%, mean gradient: 31±5 mmHg) low gradient LVEF prospectively enrolled ROTAS trial, 42 underwent both DSE CT calcium score. An score &amp;gt; 1200 AU women 2000 men was used as a referral limit AS. The Youden method best...

10.1093/ehjci/jeae333.136 article EN European Heart Journal - Cardiovascular Imaging 2025-01-01

Aortic stenosis (AS) frequently coexists with coronary artery disease (CAD), complicating revascularization decisions. The use of physiology indices, such as the fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and (CFR), in AS patients remains debated, particularly after transcatheter aortic valve implantation (TAVI). In this study, we employ computational fluid dynamics (CFD) to evaluate hemodynamics assess changes wall shear stress (WSS) before TAVI. Our analysis...

10.3390/bioengineering12040339 article EN cc-by Bioengineering 2025-03-26

Early detection and accurate estimation of aortic stenosis (AS) severity are the most important predictors successful long-term outcomes in patients. Current clinical parameters used for evaluation AS have several limitations including flow dependency. Estimation is specifically challenging patients with low-flow low transvalvular pressure gradient conditions. A proper diagnosis these needs a comprehensive left ventricle (LV) hemodynamic loads. This study has two objectives: (1) developing...

10.1371/journal.pone.0086793 article EN cc-by PLoS ONE 2014-01-28

Valve effective orifice area EOA and transvalvular mean pressure gradient (MPG) are the most frequently used parameters to assess aortic stenosis (AS) severity. However, MPG measured by cardiovascular magnetic resonance (CMR) may differ from one transthoracic Doppler-echocardiography (TTE). The objectives of this study were: 1) identify factors responsible for measurement discrepancies CMR versus TTE in AS patients; 2) investigate effect flow vorticity on severity assessment CMR; 3) evaluate...

10.1186/1532-429x-15-84 article EN cc-by Journal of Cardiovascular Magnetic Resonance 2013-01-01

AimsThe aim of this paper is to report clinical characteristics, consequences, echocardiographic features, and pathological findings encountered in patients suffering from valvular disease associated with benfluorex exposure a multicentre French registry.

10.1093/ejechocard/jeq172 article EN European Journal of Echocardiography 2010-12-30
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