A5001608378- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Advanced Biosensing Techniques and Applications
- Methane Hydrates and Related Phenomena
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Atmospheric and Environmental Gas Dynamics
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Biosensors and Analytical Detection
- CO2 Sequestration and Geologic Interactions
- Cardiovascular Effects of Exercise
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- Homelessness and Social Issues
- Advanced biosensing and bioanalysis techniques
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Protein Tyrosine Phosphatases
- Respiratory Support and Mechanisms
Hôpital Maisonneuve-Rosemont
2023
Université Laval
2010-2021
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2010-2021
Centre Hospitalier Universitaire Sainte-Justine
2003-2018
Saskatoon Medical Imaging
2018
Montreal Heart Institute
2007-2018
Institute of Cardiology
2018
Parallax Research (United States)
2017
McGill University and Génome Québec Innovation Centre
2011-2015
McGill University
2006-2015
The mammalian target of rapamycin (mTOR) pathway integrates insulin and nutrient signaling in numerous cell types. Recent studies also suggest that this negatively modulates to phosphatidylinositol 3-kinase/Akt adipose muscle cells. However, it is still unclear whether activation the mTOR increased obesity if could be involved promotion resistance. In paper we show basal (fasting state) its downstream S6K1 markedly elevated liver skeletal obese rats fed a high fat diet compared with...
Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis conservative therapy but high operative mortality when treated surgically. Recently, transcatheter valve implantation (TAVI) has emerged as an alternative to surgical replacement (SAVR) for patients considered at or prohibitive risk. The objective of this study was compare TAVI SAVR respect postoperative recovery LVEF in LV systolic function.Echocardiographic data were...
Aims Abnormal exercise test defined as the occurrence of limiting symptoms, fall in blood pressure below baseline, or complex ventricular arrhythmias is useful to predict clinical events asymptomatic patients with aortic stenosis (AS). The purpose this study was determine whether exercise-stress echocardiography (ESE) adds any incremental prognostic value resting AS having a normal response. Methods and results One hundred eighty-six at least moderate preserved LV ejection fraction (>/=50%)...
Constitutive activation of the MAP kinase MEK1 induces oncogenic transformation in intestinal epithelial cells. Loss cell-cell adhesion followed by dissociation structures is a prerequisite for increased cell motility and tumor invasion. This phenotypic switch designated epithelial-to-mesenchymal transition (EMT). EMT also plays an important role determining dissemination tumors. However, EMT, invasion metastasis has not been elucidated. To determine functions activated tumorigenesis, we...
DNA microarrays were rapidly scaled up from 256 to 6.5 million targets, and although antibody proposed earlier, sensitive multiplex sandwich assays have only been a few tens of targets. Cross-reactivity, arising because detection antibodies are mixed, is known weakness that mitigated by lengthy optimization. Here, we introduce (1) vulnerability as metric for assays. The cross-reactivity increases quadratically with the number together experimental results, substantiates scaling unfeasible....