A5007108865- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Parathyroid Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Health, Environment, Cognitive Aging
- Congenital Heart Disease Studies
- Hepatitis C virus research
- Atherosclerosis and Cardiovascular Diseases
- Streptococcal Infections and Treatments
- Nuclear Receptors and Signaling
- COVID-19 and healthcare impacts
- Aortic Thrombus and Embolism
- COVID-19 Clinical Research Studies
Université Laval
2017-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2017-2025
Amyloidosis Foundation
2024
Université Paris-Est Créteil
2024
Inserm
2024
Montreal Heart Institute
2018-2023
Ollscoil na Gaillimhe – University of Galway
2021
Karolinska University Hospital
2021
Karolinska Institutet
2021
Royal Brompton Hospital
2021
Background: This study aimed to compare echocardiographic findings in low-risk patients with severe aortic stenosis after surgical valve replacement (SAVR) or transcatheter (TAVR). Methods: The PARTNER 3 trial (Placement of Aortic Transcatheter Valves) randomized 1000 and low risk undergo either transfemoral TAVR the balloon-expandable SAPIEN SAVR. Transthoracic echocardiograms obtained at baseline 30 days 1 year procedure were analyzed by a consortium 2 echocardiography core laboratories....
<h3>Importance</h3> In low-flow, low-gradient aortic stenosis (LFLG AS), the severity of left ventricular dysfunction remains a key factor in evaluation valve replacement. <h3>Objective</h3> To evaluate clinical outcomes and changes ejection fraction (LVEF) after transcatheter replacement (TAVR) patients with LFLG AS severe dysfunction. <h3>Design, Setting, Participants</h3> This multicenter registry is substudy True or Pseudo-Severe Aortic Stenosis–TAVI that included classic AS, defined as...
This study aimed to compare incidence and impact of measured prosthesis-patient mismatch (PPMM) versus predicted PPM (PPMP) after surgical aortic valve replacement (SAVR) transcatheter (TAVR). TAVR studies have used effective orifice area indexed (EOAi) body surface (BSA) define PPM, but most SAVR series EOAi. difference may contribute discrepancies in outcomes between series. The analyzed patients from the PARTNER (Placement Aortic Transcatheter Valves) 2A trial 2 SAPIEN 3 Intermediate Risk...
BACKGROUND: Aortic valve calcification (AVC) has been shown to be a powerful assessment of aortic stenosis (AS) severity and predictor adverse outcomes. However, its accuracy in patients with low-flow AS not yet proven. The objective the study was assess predictive value AVC classical (CLF, that is, reduced left ventricular ejection fraction) or paradoxical (PLF, preserved AS. METHODS: We prospectively included 641 patients, 319 (49.8%) CLF-AS 322 (50.2%) PLF-AS, who underwent Doppler...
Background No randomized comparison of early (ie, ≤3 months) aortic valve replacement (AVR) versus conservative management or transcatheter AVR (TAVR) surgical has been conducted in patients with low-flow, low-gradient (LFLG) stenosis (AS). Methods and Results A total 481 consecutive (75±10 years; 71% men) LFLG AS (aortic area ≤0.6 cm
Although aortic valve replacement is associated with a major benefit in high-gradient (HG) severe stenosis (AS), the results low-gradient (LG, mean gradient <40 mm Hg) AS are conflicting. LG may be subdivided classical low-flow (left ventricular ejection fraction <50%) and (CLF-LG); paradoxical ≥50% but stroke volume index <35 mL/m2) LG; normal-flow ≥35 LG. The primary objective to determine PARTNER 2 trial (The Placement of Aortic Transcatheter Valves) registry outcomes after 4...
This study sought to compare cardiac magnetic resonance (CMR) characteristics according different flow/gradient patterns of aortic stenosis (AS) and evaluate their prognostic value in patients with low-gradient AS.This international prospective multicentric included 147 moderate severe AS who underwent comprehensive CMR evaluation left ventricular global longitudinal strain (LVGLS), extracellular volume fraction (ECV), late gadolinium enhancement (LGE). All were classified as followings:...
Abstract Background Guidelines advocate the use of dobutamine echocardiography (DSE) in low-gradient aortic stenosis (LGAS: AVA&lt;1cm² with AVMG&lt;40mmHg) reduced left ventricular ejection fraction (LVEF &lt;50%) for determining AS severity and deciding on subsequent patient management. However, a significant proportion patients have inconclusive DSE (indeterminate AS). Purpose We aimed to assess impact management LGAS LVEF as well application transaortic flow-based criteria...
The lesions observed in AS have been shown to be sex specific, with women presenting extensive fibrotic remodeling while men developing more calcification deposit. We thus aimed evaluate the influence of and hormones on pathophysiology aortic valve stenosis (AS) our mouse model AS. LDLr−/−ApoB100/100IGF-II+/− mice (n = 210) were separated six different groups: (1) intact male (IM), (2) female (IF), (3) castrated (CM), (4) ovariectomized females (OF), (5) CM testosterone supplementation...
The most prevalent form of "low-gradient" aortic stenosis (AS) is characterized by the concomitant presence a small valve area (<1.0 cm2) and low mean gradient (<40 mmHg) but with preserved LV ejection fraction (≥50%) normal flow (stroke volume index ≥ 35 mL/m2). This intriguing pattern referred to as "normal-flow, low-gradient" (NF-LG) AS matter debate. Some studies suggest that this NF-LG moderate AS, whereas others report about half these patients actually have true severe thus benefit...
ABSTRACT Background Aortic valve calcification (AVC) has been shown to be a powerful assessment of aortic stenosis severity (AS) and predictor adverse outcome. However, its accuracy in patients with low-flow AS not yet proven. Objectives To assess the predictive value AVC classical (CLF, i.e. low left ventricular ejection fraction [LVEF]) or paradoxical (PLF, flow preserved LVEF) patients. Methods We prospectively include 641 patients, 319 (49.8%) CLF-AS 322 (50.2%) PLF-AS who underwent...
Low rest transaortic flow rate (FR) has been shown previously to predict mortality in low-gradient aortic stenosis. However limited prognostic data exists on stress FR during low-dose dobutamine echocardiography. We aimed assess the value of for detection valve stenosis (AS) severity and prediction mortality.This is a multicenter cohort study patients with reduced left ventricular ejection fraction (aortic area <1 cm2 mean gradient <40 mm Hg) who underwent echocardiography identify AS...
In patients with low-gradient (LG) aortic stenosis (AS), confirming disease severity and indication of intervention often requires dobutamine stress echocardiography (DSE) or valve calcium scoring by computed tomography. We hypothesized that the mean transvalvular pressure gradient to effective orifice area ratio (MG/EOA, in mm Hg/cm
Abstract Background The frequent association between transthyretin wild‐type (TTRwt) cardiac amyloidosis (CA) and aortic stenosis (AS) suggests a bidirectional relationship: TTRwt‐CA could induce AS vice versa. Systemic manifestations may highlight this interaction: systemic amyloidogenesis would lead to symptoms, CA, AS, whereas the myocardial stresses induced by degenerative might promote local without symptoms. Carpal tunnel syndrome (CTS) is most frequently reported extracardiac symptom....