A5034685036- Natural Language Processing Techniques
- Topic Modeling
- Speech and dialogue systems
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Text Readability and Simplification
- Advanced Text Analysis Techniques
- TGF-β signaling in diseases
- Speech Recognition and Synthesis
- Semantic Web and Ontologies
- Video Analysis and Summarization
- Monoclonal and Polyclonal Antibodies Research
- Biomedical Text Mining and Ontologies
- Music and Audio Processing
- Peroxisome Proliferator-Activated Receptors
- Algorithms and Data Compression
- Cell Adhesion Molecules Research
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Connective Tissue Growth Factor Research
- AI in Service Interactions
- Cholesterol and Lipid Metabolism
- Multimodal Machine Learning Applications
- Translation Studies and Practices
Université d'Avignon et des Pays de Vaucluse
2011-2024
Laboratoire Informatique d'Avignon
2012-2023
GlaxoSmithKline (France)
2008-2015
GlaxoSmithKline (United Kingdom)
2004-2015
Département d'Informatique
2010
Translational Therapeutics (United States)
2010
GlaxoSmithKline (United States)
2007-2010
University of Pennsylvania
2010
Computer Research Institute of Montréal
2009
Université de Montréal
2009
Nonalcoholic steatohepatitis (NASH) may progress to liver fibrosis and cirrhosis. Mechanisms directly involved in the development of have been poorly investigated. Because connective tissue growth factor (CTGF) is an intermediate key molecule pathogenesis fibrosing chronic diseases potentially induced by hyperglycemia, aims this study were (1) expression CTGF vivo both human biopsy specimens patients with NASH experimental model obesity type II diabetes (Zucker rats); (2) analyze effects...
Connective tissue growth factor (CTGF) stimulates in vitro fibroblast proliferation and extracellular matrix synthesis. The aim of this study was to assess the role CTGF liver fibrogenesis. expression investigated both at protein mRNA level biopsies chronic diseases, experimental models fibrosis, hepatic stellate cells culture. immunostaining observed most human with significant fibrosis. An increase associated a higher score fibrosis group hepatitis C (χ 2 = 9.3; P < .01) non-hepatitis...
We demonstrate here that the CD44 molecule, which mediates lymphocyte adhesion to high endothelial venules (HEV), is also involved in delivery of an activation signal T cell. have produced a mAb (H90) able block binding lymphocytes venules. H90 had no effect on [3H]TdR incorporation whole PBL stimulated by lectins, allogeneic cells, or CD3 soluble phase; contrast, it strongly increased CD2 pairs linked plastic culture plates, when purified cells were used, could efficiently induce them...
Optimization of the screening hit 1 led to identification novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent selective inhibitors transforming growth factor-β type I receptor, ALK5. Compounds 15 19, inhibited ALK5 autophosphorylation with IC50 = 6 4 nM, respectively, showed activities in both binding cellular assays exhibited selectivity over p38 mitogen-activated protein kinase. The X-ray crystal structure 19 complex human is described, confirming mode proposed...
We previously reported that a systemic liver X receptor (LXR) agonist promoted macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed multiple tissues involved RCT (macrophages, liver, intestine), we analyzed the effect of tissue-specific agonism on mRCT.In initial studies, GW3965 failed to promote mRCT setting which was macrophages but not or intestine. To evaluate activation specifically small intestine mRCT, wild-type mice were treated with either...
1 Chronic liver disease is characterized by an exacerbated accumulation of matrix, causing progressive fibrosis, which may lead to cirrhosis. Transforming growth factor beta (TGF-beta), a well-known profibrotic cytokine, transduces its signal through the ALK5 ser/thr kinase receptor, and increases transcription different genes including PAI-1 collagens. The identification GW6604 (2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine), inhibitor, allowed us evaluate therapeutic potential...
Monoclonal antibody (MAb) GT2 defines a unique epitope on the CD2 molecule. triggers T cell mitosis in combination with any MAb directed against 9.6/T11(1) or D66, two previously defined epitopes. We have shown already that accessory cells (AC) are required for plenary T-PBL activation by pair of Ab D66 + 9.6/T11(1). In this study, we further investigated their role and found it to vary anti-CD2 used. When purified preparation is used, level [3H]TdR incorporation observed anti-(GT2...
Recently we described an HLA B27-restrlcted peptide derived from HIV gag p24 protein. In this study have isolated the nucleoprotein (NP) of influenza A virus. The shortest fragment recognized by cytotoxic T lymphocyte (CTL) is eight amlno acids long, residues 384–391. Comparison sequence these two B27 restricted peptides reveals homologies which can be aligned one to other. Of residues, are Identical: tryptophan and Isoleucine. Both a positively charged residue at N terminus, lysine position...
Inhibitors of transforming growth factor beta (TGF-beta) type I receptor (ALK5) offer a novel approach for the treatment fibrotic diseases such as renal, hepatic, and pulmonary fibrosis. The optimization phenylpyridine pyrazole series (1a) led to identification potent, selective, orally active ALK5 inhibitors. cellular potency pharmacokinetics profiles these derivatives were improved several compounds presented antifibrotic activity when administered rats in an acute liver model...
Peroxisome proliferator-activated receptor delta (PPARdelta) is involved in regulation of energy homeostasis. Activation PPARdelta markedly increases fecal neutral sterol secretion, the last step reverse cholesterol transport. This phenomenon can neither be explained by increased hepatobiliary nor reduced absorption. To test hypothesis that activation leads to stimulation transintestinal efflux (TICE), we quantified it intestine perfusions FVB mice treated with agonist GW610742. exclude...
Abstract We have previously described a molecule on the SRBC surface which, in addition to sheep equivalent of LFA-3, is involved process rosette formation. It made single, 14- 19-kDa, polypeptide chain, and we termed this S14. now identified, human E with similar Mr albeit somewhat higher (19 kDa). The mAb against H19 efficiently block autologous or homologous rosettes by binding E. In addition, purified molecules dose-dependent manner. molecule, like not limited surface, but also present...
Semantic Textual Similarity (STS) is the basis of many applications in Natural Language Processing (NLP). Our system combines convolution and recurrent neural networks to measure semantic similarity sentences. It uses a network take account local context words an LSTM consider global This combination helps preserve relevant information sentences improves calculation between model has achieved good results competitive with best state-of-the-art systems.
In studies of antigenic peptide presentation, we have found a healthy volunteer whose lymphoblastoid cells were unable to present three different virus-derived epitopes cytotoxic T lymphocytes (CTL) despite expressing the correct restricting HLA-B27 molecules on cell surface. B lines established from other members donor's family, including individuals suffering ankylosing spondylitis and related diseases, tested for their ability function as target in same assay. None eight that expressed...
TGF-beta, and its type 1 (ALK5) receptor, are critical to the pathogenesis of fibrosis. In toxicologic studies 4 or more days in 10-week-old Sprague-Dawley rats, using an ALK5 inhibitor (GW788388), expansion hypertrophic proliferation zones femoral physes were noted. Subphyseal hyperostosis, chondrocyte hypertrophy/hyperplasia, increased matrix present. Physeal laser microdissected from inhibitor-treated control rats sacrificed after 3 treatment. Transcripts for TGF-beta1, TGF-beta2, ALK5,...
The HLA-B27-restricted HIV gag cytotoxic T-lymphocyte (CTL) epitope, 265–279, is highly conserved amongst HIV-1 isolates, only one, HIV-1ELI, having a single amino acid substitution. Over the same region HIV-2 differs by five acids. As broadly cross-protective AIDS vaccine should protect against infection from all isolates of and HIV-2, we tested CTL specific for 265–279 epitope with peptide analogues two simian immunodeficiency virus (SIV) recombinant vaccinia viruses expressing respective...
Liver X receptor-alpha (LXRalpha) and LXRbeta are ligand-activated transcription factors belonging to the nuclear receptor superfamily. They have been identified as key players in cholesterol homeostasis lipid glucose metabolism well immune inflammatory responses. In small intestine, LXRs shown not only regulate absorption excretion but also promote high-density lipoprotein biogenesis via ATP-binding cassette A1 signaling pathway. Here, using gene expression assays, we PPARalpha an...