A5081330050- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Complement system in diseases
- Blood groups and transfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
Maison des Sciences de l’Homme de Dijon
2011-2025
Université de Bourgogne
1997-2024
Centre Hospitalier Universitaire Dijon Bourgogne
2015-2024
Laboratoire des Sciences du Numérique de Nantes
2023
Nantes Université
2023
Centre de recherche Translationnelle en Médecine moléculaire
2018
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
Chongqing Medical University
2017
Inserm
2003-2016
Centre Hospitalier Universitaire de Nice
1999-2016
Proteins of the Bcl-2 family are intracellular membrane-associated proteins that regulate programmed cell death (apoptosis) either positively or negatively by as yet unknown mechanisms. Bax, a pro-apoptotic member family, was shown to form channels in lipid membranes. Bax triggered release liposome-encapsulated carboxyfluorescein at both neutral and acidic pH. At physiological pH, could be blocked Bcl-2. Bcl-2, contrast, pH only. In planar bilayers, formed pH- voltage-dependent...
Children with B cell non-Hodgkin's lymphoma who have not relapsed 1 year after diagnosis and treatment are generally cured. We report here the results of in 114 children all had a minimum follow-up 20 months. The protocol LMB 0281 from French Pediatric Oncology Society was used. This nine-drug intensive-pulsed chemotherapy based on high-dose cyclophosphamide, methotrexate (HD MTX), cytosine arabinoside (ara-C) continuous infusion. CNS prophylaxis only. No local irradiation performed....
We obtained a monoclonal antibody, A50, after immunizing Biozzi's high responder strain of mice with T cell chronic lymphocytic leukemia (T-CLL) cells. A50 recognized an antigen present on the surface B cells from many patients and lineage any subject we tested. could not find this either normal or other non-T malignancies. On cells, was subpopulation thymus most peripheral The T-CLL, Sézary's disease, subset o lymphoma. seemed to belong complex set antigenic determinants that had defined...
CD47 on the surface of T cells was shown in vitro to mediate either cell activation or, presence high amounts thrombospondin (TSP), apoptosis. We report here that CD47-deficient mice, as well TSP-1 or TSP-2-deficient sustain oxazolone-induced inflammation for more than four days, whereas wild-type mice reduce within 48 h. observe prolonged CD47-, TSP-1-, is accompanied by a local deficiency Finally, we show upon normal increase expression proapoptotic Bcl-2 family member BNIP3...
Nutritional assessment is not included yet as a major recommendation in lung cancer guidelines. The purpose of this study was thus to assess the influence on surgical outcome nutritional status patients with primary undergoing lobectomy. We queried Epithor, national clinical database French Society Thoracic and Cardiovascular Surgery, identified retrospective cohort 19 635 having undergone lobectomy for years 2005–11. Their categorized according WHO definition: underweight (BMI < 18.5): 857...
One set of antigens is common to some chronic lymphocytic leukemia (CLL) cells bearing surface immunoglobulins (Ig) and normal T cells. Proliferating from thirty-eight patients were studied with four antisera recognizing human but not B These raised in rabbits against (a) Sezary cells, (b) blood lymphocytes a patient sex-linked agammaglobulinemia, (c) lymphoblasts (d) thymus In CLL cases, the expressed receptor for sheep erythrocytes lacked Ig. Cells thirty-four cases bore monoclonal Ig did...
CD40 ligand (CD40L) is expressed on the surface of activated CD4+ T cells, basophils, and mast cells. Binding C40L to its receptor, CD40, B cells stimulates cell proliferation, adhesion differentiation. A preparation soluble, recombinant CD40L (Tyr-45 Leu-261), containing full-length 29-kDa protein two smaller fragments 18 14 kDa, has been shown induce differentiation derived either from normal donors or patients with X-linked hyper-IgM syndrome (Durandy, A., Schiff, C., Bonnefoy, J.-Y.,...
Abstract E2/CD99 is a 32-kDa transmembrane molecule that does not belong to any known family of proteins. It appears regulate adhesion properties T cells as previously reported, in particular, the induction homotypic CD4+ CD8+ thymocytes. Apoptosis induced via displays characteristic morphologic features, but includes early mitochondrial alterations and phosphatidylserine exposure at outer leaflet plasma membrane. followed by detectable DNA fragmentation, its time course much longer than...
Anti-D66 is a monoclonal antibody able to inhibit E-rosette formation of T cells both at 4 degrees C and 37 degree but that does not cell rosette with neuraminidase or 2-amino-ethylisothiouronium bromide (AET)-pretreated E. As demonstrated by capping experiments, it defines an epitope, D66, directly involved in formation. D66 distinct from the epitope defined 9.6 because 9.6, previously "pan-T" antibody, inhibits E(AET) no cross-blocking occurred between antibodies fixation. However, are...