A5039089507- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Single-cell and spatial transcriptomics
- Hereditary Neurological Disorders
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Sphingolipid Metabolism and Signaling
- Inflammasome and immune disorders
- Advanced Breast Cancer Therapies
- Hedgehog Signaling Pathway Studies
- Chromatin Remodeling and Cancer
Translational Research Institute
2023
The University of Queensland
2021-2023
Vincristine is an important component of many regimens used for pediatric and adult malignancies, but it causes a dose-limiting sensorimotor neuropathy which there no effective treatment. This study aimed to delineate the neuro-inflammatory mechanisms contributing development mechanical allodynia gait disturbances in murine model vincristine-induced neuropathy, as well identify novel treatment approaches. Here, we show that peripheral driven by activation NLRP3 inflammasome subsequent...
Abstract Background Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be classified into four major subgroups based on gene expression and genomic features. Single-cell transcriptome studies have defined cellular states underlying each MB subgroup; however, spatial organisation these diverse cell how this impacts response to therapy remains determined. Methods Here, we used spatially resolved transcriptomics define diversity within sonic hedgehog (SHH) patient-derived...
Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality morbidity. Existing treatment protocols are aggressive in nature resulting significant neurological, intellectual physical disabilities for children undergoing treatment. Thus, there an urgent need improved, targeted therapies that minimize these harmful side effects. We identified candidate drugs MB using network-based systems-pharmacogenomics approach: based on results...
Abstract Background Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be classified into four major subgroups based on gene expression and genomic features. Single cell transcriptome studies have defined cellular states underlying each MB subgroup, however spatial organisation these diverse how this impacts response to therapy remains determined. Methods Here, we used spatially resolved transcriptomics define diversity within sonic hedgehog (SHH) patient-derived model...
Abstract Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be classified into four major subgroups on basis gene expression and genomic features. Single cell transcriptome studies have defined cellular states underlying each MB subgroup, however spatial organisation these diverse how this impacts response to therapy remains determined. Here, we used spatially resolved transcriptomics define diversity within sonic hedgehog (SHH) patient-derived model identify cells...
Abstract Background Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality morbidity. Existing treatment protocols are aggressive in nature resulting significant neurological, intellectual physical disabilities for children undergoing treatment. Clearly, there an urgent need improved, targeted therapies that minimize these harmful side effects. Methods We identified candidate drugs MB using network-based...