A5057526853- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Radiation Dose and Imaging
- Nuclear Physics and Applications
- Nuclear physics research studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Digital Radiography and Breast Imaging
- Astronomical and nuclear sciences
- Radiation Shielding Materials Analysis
- Ocular Oncology and Treatments
- Nuclear reactor physics and engineering
- Atomic and Subatomic Physics Research
- Management of metastatic bone disease
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2020
Agrobioinstitute
2020
Inserm
2015
Université Joseph Fourier
2012
Kettering University
2009-2011
University of Chicago
2011
University of Pennsylvania
2011
The University of Texas MD Anderson Cancer Center
2011
University of Arizona
2011
Monte Carlo simulation is an essential tool in emission tomography that can assist the design of new medical imaging devices, optimization acquisition protocols and development or assessment image reconstruction algorithms correction techniques. GATE, Geant4 Application for Tomographic Emission, encapsulates libraries to achieve a modular, versatile, scripted toolkit adapted field nuclear medicine. In particular, GATE allows description time-dependent phenomena such as source detector...
In this study, a measurement protocol is presented that improves the precision of dose measurements using flat-bed document scanner in conjunction with two new GafChromic® film models, HS and Prototype A EBT exposed to photon beams. We established sources uncertainties measurements, governed by calibration curve fit parameters contributions. have quantitatively assessed influence different steps on overall uncertainty. Applying described paper Agfa Arcus II scanner, one-sigma uncertainty for...
The purpose of this educational report is to provide an overview the present state-of-the-art PET auto-segmentation (PET-AS) algorithms and their respective validation, with emphasis on providing user help in understanding challenges pitfalls associated selecting implementing a PET-AS algorithm for particular application.A brief description different types provided using classification based method complexity type. advantages limitations current are highlighted publications existing...
Two recently introduced GafChromic film models, HS and XR-T, have been developed as more sensitive uniform alternatives to MD-55-2 film. The model has specifically designed for measurement of absorbed dose in high-energy photon beams (above 1 MeV), while the XR-T measurements low energy (0.1 MeV) photons. goal this study is compare sensitometric curves estimated dosimetric uncertainties associated with seven different dosimetry systems two new models. densitometers tested are: LKB Pharmacia...
Background Current measurements of multiple myeloma disease burden are suboptimal. Daratumumab is a monoclonal antibody that targets CD38, an antigen expressed on nearly all cells. Purpose To demonstrate preclinical and first-in-human application composed the native daratumumab labeled with positron-emitting radionuclide zirconium 89 (89Zr) through chelator deferoxamine (DFO), or 89Zr-DFO-daratumumab, for immunologic PET imaging myeloma. Materials Methods 89Zr-DFO-daratumumab was synthesized...
Radiochromic film (RCF) is attractive as a thin, high resolution, 2D planar dosimeter. We have studied the uniformity, linearity, and reproducibility of commercially supplied RCF system (model MD‐55). Forty 12 cm long strips were exposed to uniform doses 6 MV x rays. Optical density (OD) distributions measured by helium‐neon scanning laser (633 nm) densitometer also with manual densitometer. All showed 8%–15% variations in OD values independent densitometry technique which are evidently due...
The three-body decay $^{12}\mathrm{O}\ensuremath{\rightarrow}2p+^{10}\mathrm{C}$ was studied following production via single-neutron stripping from a radioactive $^{13}\mathrm{O}$ projectile. This is the first observation of two-proton emission an unbound ground state where one-proton channel energetically closed beyond lightest case $^{6}\mathrm{Be}$. No evidence for $^{2}\mathrm{He}$ seen, despite predictions large diproton branching ratio. An upper limit 7% (95% C.L.) established this...
The recently developed GATE (GEANT4 application for tomographic emission) Monte Carlo package, designed to simulate positron emission tomography (PET) and single photon computed (SPECT) scanners, provides the ability model account effects of noncollinearity, off-axis detector penetration, size response, range, scatter, patient motion on resolution quality PET images. objective this study is validate a within General Electric (GE) Advance/Discovery Light Speed (LS) scanner. Our...
Purpose: To establish a new clinical procedure in frameless stereotactic radiosurgery (SRS) for patient setup verification at treatment couch angles as well head‐motion monitoring during using video‐based optical surface imaging (OSI). Methods: A three‐dimensional (3D) OSI system with three ceiling‐mounted camera pods was employed to verify monitor head motion treatment. noninvasive immobilization device utilized, which includes an alpha mold and dental mouthpiece vacuum suction; both were...
Objective To determine the feasibility and prognostic value of 3D measuring ablation margins using a dedicated image registration software.Methods This retrospective study included 104 colorectal liver metastases in 68 consecutive patients that underwent microwave between 08/2012 08/2019. The minimal margin (MM) was measured 2D anatomic landmarks on contrast enhanced CT(CECT) 4–8 weeks post-ablation, an software immediate post-ablation CECT. Local tumor progression (LTP) assessed by imaging...
We present an evaluation of the precision and accuracy image-based radiochromic film (RCF) dosimetry performed using a commercial RCF product (Gafchromic MD-55-2, Nuclear Associates, Inc.) high-spatial resolution (100 μm pixel size) He–Ne scanning-laser film-digitizer (Personal Densitometer, Molecular Dynamics, as optical density (OD) imaging system. The this system are evaluated by performing in well characterized conformal external beam brachytherapy high dose-rate (HDR) radiation fields....
Abstract Background Prior to selective internal radiotherapy of liver tumors, a determination the lung shunt fraction (LSF) is performed using 99mTc- macroaggregated albumin (99mTc-MAA) injected into hepatic artery. Most commonly planar but sometimes SPECT/CT images are acquired upon which regions interests drawn manually define and lung. The LSF then calculated by taking count ratios between these two organs. An accurate estimation necessary avoid an excessive pulmonary irradiation dose....
Very few dosimetry data are available for the current generation of high-dose-rate (HDR) 192Ir sources, which have broad application in remotely afterloaded brachytherapy. The authors measured two-dimensional dose rate distribution around a microSelectron-HDR source and used results to validate Monte Carlo simulations. Thermoluminescent dosimeters (TLDs) solid-water phantoms were measure transverse-axis rates distance range 0.5-10 cm polar dose-rate profiles at 1.5, 3 5 from source. At close...
Despite widespread use of high‐intensity Ir‐192 remotely afterloaded sources, no published measured or calculated dose‐rate tables for currently used source designs are available. For a pulsed source, both transverse axis (0.5–10 cm) and two‐dimensional polar profiles (1.5, 3, 5 were with thermoluminescent dosimetry in solid water phantom. Dose rates normalized to air‐kerma strength, the geometry was verified by pinhole autoradiography transmission radiography. At each measurement point,...
Correcting positron emission tomography (PET) images for the partial volume effect (PVE) due to limited resolution of PET has been a long-standing challenge. Various approaches including incorporation system response function in reconstruction have previously tested. We present post-reconstruction PVE correction based on iterative deconvolution using 3D maximum likelihood expectation-maximization (MLEM) algorithm. To achieve convergence we used one step late (OSL) regularization procedure...
Purpose: The need for an accurate lesion segmentation tool in PET is a prerequisite the estimation of response to therapy, radionuclide dosimetry, and application radiotherapy planning. In this work, authors have developed iterative method based on mathematical fit deduced from Monte Carlo simulations estimate tumor thresholds. Methods: GATE software, GEANT4 tool, was used model GE Advance scanner geometry. Spheres ranging between 1 diameters were simulated high diameter cylinder. spheres...
The plastic scintillator (PS) is a promising dosimeter for brachytherapy and other low-energy photon applications because of its high sensitivity approximate tissue equivalence. As part our project to develop new PS material which maximizes radiological equivalence water, we have measured the response, (light output/unit air kerma), bremsstrahlung (20 57 keV average energies) x-rays as well photons emitted by , sources, all were calibrated in terms kerma. systems studied standard commercial...
This work describes PETSTEP (PET Simulator of Tracers via Emission Projection): a faster and more accessible alternative to Monte Carlo (MC) simulation generating realistic PET images, for studies assessing image features segmentation techniques.PETSTEP was implemented within Matlab as open source software. It allows three-dimensional images from PET/CT data or synthetic CT maps, with user-drawn lesions user-set acquisition reconstruction parameters. used reproduce the NEMA body phantom...
The aim of this paper is to define the requirements and describe design implementation a standard benchmark tool for evaluation validation PET-auto-segmentation (PET-AS) algorithms. This work follows recommendations Task Group 211 (TG211) appointed by American Association Physicists in Medicine (AAPM).The published AAPM TG211 report were used derive set required features guide structure benchmarking software tool. These items included selection appropriate representative data reference...