George Α. Alexiou

ORCID: 0000-0003-0257-4481
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About
Contact & Profiles
Research Areas
  • Glioma Diagnosis and Treatment
  • Meningioma and schwannoma management
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Cerebrospinal fluid and hydrocephalus
  • Neurofibromatosis and Schwannoma Cases
  • Brain Metastases and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Fetal and Pediatric Neurological Disorders
  • Vascular Malformations Diagnosis and Treatment
  • Spinal Dysraphism and Malformations
  • Radiopharmaceutical Chemistry and Applications
  • Neuroblastoma Research and Treatments
  • Cancer Cells and Metastasis
  • Medical Imaging Techniques and Applications
  • S100 Proteins and Annexins
  • Cancer Genomics and Diagnostics
  • Spinal Fractures and Fixation Techniques
  • Spine and Intervertebral Disc Pathology
  • Advanced Neuroimaging Techniques and Applications
  • Cardiac Arrest and Resuscitation
  • Trauma and Emergency Care Studies
  • Chromatin Remodeling and Cancer
  • Head and Neck Surgical Oncology
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Neurosurgical Procedures and Complications

University Hospital of Ioannina
2016-2025

University of Ioannina
2016-2025

Primary Source
2023

Deleted Institution
2022

Mitera Hospital
2022

Iaso Children’s Hospital
2008-2015

National and Kapodistrian University of Athens
2010-2014

Hospital del Niño
2010-2014

Children's Hospital
2011-2013

Boston Children's Hospital
2009-2013

Cancer is a life-threatening disease and one of the leading causes death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures been investigated for their multimodal properties. Curcumin polyphenol isolated from rhizomes Curcuma longa has widely studied its anti-inflammatory, anti-oxidant, effects. acts on regulation different aspects cancer development,...

10.3390/cancers16081554 article EN Cancers 2024-04-18

From the initial discovery of a medical intervention to highly cited article is long road, and even this not end journey.

10.1126/science.1160622 article EN Science 2008-09-05

<h3>BACKGROUND AND PURPOSE:</h3> Neuropathologic studies in experimental and human glaucoma have demonstrated degenerative changes the optic pathway. The purpose of this study was to assess pathway POAG by using VBM DTI. <h3>MATERIALS METHODS:</h3> Eighteen patients 57.05 ± 11.38 years age with 8.30 5.14 years9 duration 18 control subjects underwent a complete ophthalmologic examination, including quantification RNFLT Stratus OCT 3, brain imaging. imaging protocol consisted T1-weighted...

10.3174/ajnr.a2714 article EN cc-by American Journal of Neuroradiology 2011-11-24

Glioblastoma (GBM) is the most common and aggressive type of glioma has poorest survival. However, a small percentage patients with GBM survive well beyond established median. Therefore, identifying genetic variants that influence this number unusually long-term survivors may provide important insight into tumor biology treatment.Among 590 primary GBM, we evaluated associations survival 100 top-ranking susceptibility single nucleotide polymorphisms from our previous genome-wide association...

10.1200/jco.2009.26.6213 article EN Journal of Clinical Oncology 2010-04-06

To date, many potent compounds have been found which are derived from plants and herbs possess anticancer properties due to their antioxidant effects. 9″-Lithospermic acid methyl ester is an effective natural compound the Thymus thracicus Velen. It has proven that this substantial in different diseases, but its effects cancer not thoroughly evaluated. The aim of work was study (9″-methyl lithospermate) U87 T98 glioblastoma cell lines. Its on cellular viability were assessed via Trypan Blue...

10.3390/ijms25042094 article EN International Journal of Molecular Sciences 2024-02-08

Coagulopathy after traumatic brain injury (TBI) is a frequent event and associated with patients' prognosis. TBI also stress response that includes hyperglycemia. This study investigated if coagulopathy occurrence admission blood glucose levels in patients TBI.This retrospectively evaluated who were admitted to neurosurgical department over 4-year period. was defined as an aPTT >40 seconds and/or INR >1.2 platelet count <120*10(9) per litre.One-hundred forty-nine included the study....

10.3109/02699052.2014.888769 article EN Brain Injury 2014-02-24

Curcumin, a bioactive polyphenol, is known to have anticancer properties. In this study, the effectiveness of curcumin pretreatment as strategy for radio-sensitizing glioblastoma cell lines was explored. For this, U87 and T98 cells were treated with curcumin, exposed 2 Gy or 4 irradiation, combined effect compared antiproliferative each agent when given individually. Cell viability proliferation evaluated trypan blue exclusion assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...

10.3390/biomedicines9111562 article EN cc-by Biomedicines 2021-10-28
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