A5087314005- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Brain Tumor Detection and Classification
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Musculoskeletal pain and rehabilitation
- Management of metastatic bone disease
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
- Medical Imaging and Analysis
- Medical Image Segmentation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Cerebral Venous Sinus Thrombosis
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
Sahlgrenska University Hospital
2016-2025
University of Gothenburg
2016-2025
St Olav's University Hospital
2016-2025
Neuroscience Institute
2023
Swedish Academy
2023
Norwegian University of Science and Technology
2011-2022
Uppsala University
2020
Karolinska University Hospital
2020
Karolinska Institutet
2020
Copenhagen University Hospital
2020
There are no controlled studies on surgical treatment of diffuse low-grade gliomas (LGGs), and management is controversial.To examine survival in population-based parallel cohorts LGGs from 2 Norwegian university hospitals with different strategies.Both neurosurgical departments exclusive providers adjacent geographical regions regional referral practices. In hospital A diagnostic biopsies followed by a "wait scan" approach has been favored (biopsy watchful waiting), while early resections...
Infiltrating low-grade gliomas (LGG; WHO grade 2) typically present with seizures in young adults. LGGs grow continuously and usually transform to higher of malignancy, eventually causing progressive disability premature death. The effect up-front surgery has been controversial the impact molecular biology on is unknown. We now long-term results upfront surgical resection compared watchful waiting light recently established markers.Population-based parallel cohorts were followed from two...
Abstract Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) in clinical development for solid tumors, but yet to be evaluated glioma. Here, we demonstrate that systemic delivery of αCD40 preclinical glioma models induces the formation tertiary lymphoid structures (TLS) proximity meningeal tissue. In treatment-naïve patients, presence TLS correlates with increased T cell infiltration. However, hypofunctional...
PURPOSE In patients with diffuse low-grade glioma (LGG), the extent of surgical tumor resection (EOR) has a controversial role, in part because randomized clinical trial different levels EOR is not feasible. METHODS 20-year retrospective cohort 392 IDH-mutant grade 2 glioma, we analyzed combined effects volumetric and molecular factors on overall survival (OS) progression-free by recursive partitioning analysis. The OS results were validated two external cohorts (n = 365). Propensity score...
Importance The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence its efficacy lacking. Objective To investigate the burst stimulation, which involves placement an implantable pulse generator connected to electrodes with leads that travel into epidural space posterior dorsal columns, in patients radiculopathy degenerative disorders. Design, Setting, and Participants This placebo-controlled, crossover, randomized clinical trial 50...
Glioblastomas are aggressive brain tumors that largely immunotherapy resistant. This is associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T cell infiltration. LIGHT/TNFSF14 can induce high endothelial venules (HEVs) tertiary lymphoid structures (TLS), suggesting its therapeutic expression could promote recruitment. Here, we use cell-targeted adeno-associated viral (AAV) vector to express LIGHT in the glioma vasculature (AAV-LIGHT). We found systemic...
Intraoperative ultrasound imaging is used in brain tumor surgery to identify remnants. The images may some cases be more difficult interpret the later stages of operation than beginning operation. aim this paper explain causes surgically induced artefacts and how they can recognized reduced.The theoretical reasons for are addressed impact discussed. Different setups acquisition different acoustic coupling fluids fill up resection cavity evaluated with respect improved image quality.The...
<b>Objective</b> To test the equivalence for clinical effectiveness between microdecompression and laminectomy in patients with central lumbar spinal stenosis. <b>Design</b> Multicentre observational study. <b>Setting</b> Prospective data from Norwegian Registry Spine Surgery. <b>Participants</b> 885 stenosis of spine who underwent surgery at 34 orthopaedic or neurosurgical departments. Patients were treated October 2006 to December 2011. <b>Interventions</b> Laminectomy microdecompression....
Automatic extraction of features from MRI brain scans and diagnosis Alzheimer's Disease (AD) remain a challenging task. In this paper, we propose an efficient simple three-dimensional convolutional network (3D ConvNet) architecture that is able to achieve high performance for detection AD on relatively large dataset. The proposed 3D ConvNet consists five layers feature extraction, followed by three fully-connected AD/NC classification. main contributions the paper include: (a) novel...
A feature of glioblastoma (GBM) is cellular and molecular heterogeneity, both within between tumors. This variability causes a risk for sampling bias potential tumor escape from future targeted therapy. Heterogeneous intratumor gene expression in GBM well documented, but little known regarding the epigenetic heterogeneity. Variability DNA methylation tumors would have implications diagnostics, as can be used classification, subtyping, determination clinically biomarker O6-methylguanine-DNA...
This paper addresses issues of brain tumor subtype classification using Magnetic Resonance Images (MRIs) from different scanner modalities like T1 weighted, weighted with contrast-enhanced, T2 and FLAIR images. Currently most available glioma datasets are relatively moderate in size, often accompanied incomplete MRIs modalities. To tackle the commonly encountered problems insufficiently large modality image for deep learning, we propose to add augmented MR images enlarge training dataset by...
This paper addresses issues of brain tumor, glioma, grading from multi-sensor images. Different types scanners (or sensors) like enhanced T1-MRI, T2-MRI and FLAIR, show different contrast are sensitive to tissues fluid regions. Most existing works use 3D images single sensor. In this paper, we propose a novel multistream deep Convolutional Neural Network (CNN) architecture that extracts fuses the features multiple sensors for glioma tumor grading/subcategory grading. The main contributions...
Abstract Background This paper addresses issues of brain tumor, glioma, classification from four modalities Magnetic Resonance Image (MRI) scans (i.e., T1 weighted MRI, MRI with contrast-enhanced, T2 and FLAIR). Currently, many available glioma datasets often contain some unlabeled scans, are moderate in size. Methods We propose to exploit deep semi-supervised learning make full use the data. Deep CNN features were incorporated into a new graph-based framework for labels data, where 3D-2D...
In the new WHO 2021 Classification of CNS Tumors chapter "Circumscribed astrocytic gliomas, glioneuronal and neuronal tumors" encompasses several different rare tumor entities, which occur more frequently in children, adolescents, young adults. The Task Force has reviewed evidence diagnostic therapeutic interventions, is low particularly for adult patients, draw recommendations accordingly. Tumor diagnosis, based on 2021, primarily performed using conventional histological techniques;...
Outcome following brain tumor operations is often assessed by health professionals using various gross function scales. However, surprisingly little known about how modern glioma surgery affects quality of life (QOL) as reported the patients themselves. In present study authors aimed to assess changes in QOL after surgery, explore relationship between and traditional outcome parameters, examine possible predictors change QOL.Eighty-eight with were recruited from among those 16 years or older...
Observational multicenter study.To evaluate if the severity of lumbar spinal stenosis (LSS) on magnetic resonance imaging (MRI) correlates with preoperative disability, pain, or surgical outcomes.Surgeons use morphological appearance LSS MRI for clinical decision making. However, associations between radiological and outcomes remain unclear.Evaluation according to Schizas classification. Patient treatment data were retrieved from Norwegian Registry Spine Surgery. Preopertaive outcome...