A5077636380- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Computational Drug Discovery Methods
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Radiopharmaceutical Chemistry and Applications
- Spinal Fractures and Fixation Techniques
- Chemical Reactions and Isotopes
- Cell Image Analysis Techniques
- Neurosurgical Procedures and Complications
- Cardiac Arrest and Resuscitation
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Melanoma and MAPK Pathways
- Nanoparticle-Based Drug Delivery
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury Research
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
- Hip and Femur Fractures
- Trauma Management and Diagnosis
- Cancer, Stress, Anesthesia, and Immune Response
- Extracellular vesicles in disease
- Medical Imaging Techniques and Applications
University of Bergen
2015-2025
Haukeland University Hospital
2015-2025
Clinical Trial Investigators
2023
Metas (Norway)
2023
Addis Ababa University
2022
Goethe University Frankfurt
2015
Luxembourg Institute of Health
2015
University of Tübingen
2015
Czech Academy of Sciences, Institute of Experimental Medicine
2013
Ålesund Hospital
2013
Importance The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence its efficacy lacking. Objective To investigate the burst stimulation, which involves placement an implantable pulse generator connected to electrodes with leads that travel into epidural space posterior dorsal columns, in patients radiculopathy degenerative disorders. Design, Setting, and Participants This placebo-controlled, crossover, randomized clinical trial 50...
Importance Current guidelines for treating small- to medium-sized vestibular schwannoma recommend either upfront radiosurgery or waiting treat until tumor growth has been detected radiographically. Objective To determine whether provides superior volume reduction a wait-and-scan approach schwannoma. Design, Setting, and Participants Randomized clinical trial of 100 patients with newly diagnosed (<6 months) unilateral maximal diameter less than 2 cm in the cerebellopontine angle as...
The histopathological and molecular heterogeneity of glioblastomas represents a major obstacle for effective therapies. Glioblastomas do not develop autonomously, but evolve in unique environment that adapts to the growing tumour mass contributes malignancy these neoplasms. Here, we show patient-derived glioblastoma xenografts generated mouse brain from organotypic spheroids reproducibly give rise three different histological phenotypes: (i) highly invasive phenotype with an apparent normal...
Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14–15 months after surgery, radiation and chemotherapy using temozolomide (TMZ). A major problem is that the tumors acquire resistance to therapy. In effort improve therapeutic efficacy TMZ, we performed genome‐wide RNA interference (RNAi) synthetic lethality screen establish functional gene signature for TMZ sensitivity in human GBM cells. We then queried Connectivity Map database search drugs would induce...
We have previously determined the incidence and prevalence of idiopathic normal pressure hydrocephalus (iNPH) in county Vestfold Norway. This study aimed at determining surgeries for iNPH.Information about age, sex, operation year type was collected retrospectively all patients hospitalized from 2002 to 2006 with any diagnosis iNPH operated insertion a ventriculo-peritoneal or ventriculoatrial shunt system, endoscopic third ventriculostomy Norway's five regional neurosurgical centers.Two...
Abstract Background The harm‐benefit balance for early out‐of‐bed mobilisation of patients with severe acquired brain injury (ABI) in neurointensive care units (neuro‐ICUs) is unclear, and there are no clinical guidelines. This study aimed to survey the current practice perceptions among clinicians involved first Scandinavian neuro‐ICUs. Methods was a cross‐sectional, anonymous, web‐based survey; reporting follows recommended CROSS checklist. Clinicians all 14 neuro‐ICUs were eligible...
Traumatic brain injury (TBI) is a major cause of morbidity and mortality in Western countries. Effective management planning for these patients requires knowledge TBI epidemiology. The purpose this study was to describe analyze the development Nordic countries during period 1987-2001. Data on deaths were retrieved from national official statistical agencies according specified diagnostic codes. We also collected data number operations acute year 2000 all hospitals admitting trauma patients....
Biologic and therapeutic advances in melanoma brain metastasis are hampered by the paucity of reproducible predictive animal models. In this work, we developed a robust model that empowers quantitative tracking cellular dissemination tumor progression. Human cells labeled with superparamagnetic iron oxide nanoparticles (SPION) were injected into left cardiac ventricle mice visualized MRI. We showed SPION exposure did not affect viability, growth, or migration multiple cell lines across...
Our goal was to develop strategies quantify the accumulation of model therapeutics in small brain metastases using multimodal imaging, order enhance potential for successful treatment. Human melanoma cells were injected into left cardiac ventricle immunodeficient mice. Bioluminescent, MR and PET imaging applied evaluate limits detection contrast agent extravasation metastases. A pharmacokinetic estimate vascular permeability. Bioluminescent after injecting d-luciferin (molecular weight (MW)...
Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured weeks or months. Durable disease control within the is impeded by poor drug penetration across blood-brain barrier, as well intrinsic acquired resistance. Augmented mitochondrial respiration key resistance mechanism BRAF-mutant melanomas but, we show this study, dependence on may also be exploited therapeutically. We first used high-throughput pharmacogenomic profiling to...
Oligodendroglioma poses a biological conundrum for malignant adult human gliomas: it is tumor type that universally incurable patients, and yet, only few of the tumors have been established as cell populations in vitro or intracranial xenografts vivo. Their survival, thus, may emerge within specific environmental context. To determine fate oligodendroglioma an experimental model, we studied development anaplastic after implantation into enhanced green fluorescent protein (eGFP) positive...
Melanoma has the highest propensity of all cancers to metastasize brain with a large percentage late-stage patients developing metastases in central nervous system (CNS). It is well known that metastasis establishment, cell survival, and progression are affected by tumour-host interactions where changes host cellular compartments likely play an important role. In this context, miRNAs transferred tumour derived extracellular vesicles (EVs) have previously been shown create favourable...
Objective:The aim of this study was to investigate the influence age on mortality and 3-month outcome in a Norwegian cohort patients with severe traumatic brain injury.Methods: residents ≥ 16 years who were admitted injury country's 4 major trauma centres 2009 2010 included, as adults (16-64 years) elderly (≥ 65 years).Results: Half adult subjects 84% injured by falls.One-third half local hospital before being transported regional hospital.Subdural haematomas more frequent...
A tumor-to-tumor metastasis (TTM) is a rare metastatic process where primary malignant tumor metastasizes to another tumor, most commonly benign such as meningioma. Here, we present two recent cases of tumor-to-meningioma metastases (TMM) from our clinical practice and review literature. The cancers were prostate breast cancer, respectively. We reviewed the electronic medical records patients conducted literature TTM, focusing on biological mechanisms related TMM. Our first patient, man with...
Surgery for chronic subdural hematoma (CSDH) is performed to relieve brain displacement and high intracranial pressure (ICP). However, the intraoperative impression often that inside CSDH low, despite marked clinical symptoms. We wanted quantify relate this radiological characteristics. This prospective, population-based study of unilateral CSDHs was conducted over a 3-year period. were secondary other conditions, re-operations, or requiring procedures than burr hole craniostomy under local...
Patients with melanoma have a high risk of developing brain metastasis, which is associated dismal prognosis. During early stages metastasis development, the blood-brain barrier (BBB) likely intact, inhibits sufficient drug delivery into metastatic lesions. We investigated ability peptide, K16ApoE, to permeabilize BBB for improved treatment targeted therapies preclinically. Dynamic contrast enhanced MRI (DCE-MRI) was carried out on NOD/SCID mice study therapeutic window peptide-mediated...
Ethiopia is a fast-growing economy with rapid urbanization and poor occupational safety measures. Fall injuries are common frequently result in traumatic brain injury (TBI) or spinal cord (SCI). We prospectively included fall victims who were hospital-treated for neurotrauma forensically examined 2017 Addis Ababa, Ethiopia. registered sociodemographic factors, types, injuries, treatment, outcome. 117 treated 51 deceased patients (median age 27 vs. 40 years). Most injured at construction...