A5062403912- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Oral and Maxillofacial Pathology
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- S100 Proteins and Annexins
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Circular RNAs in diseases
- Diamond and Carbon-based Materials Research
- Bone health and treatments
- Nerve injury and regeneration
- Thyroid Cancer Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Protease and Inhibitor Mechanisms
- Synthesis of Tetrazole Derivatives
University of Bergen
2013-2024
Qilu Hospital of Shandong University
2023
Sichuan University
2017
Haukeland University Hospital
2013-2015
St Thomas' Hospital
2013
University of Sheffield
2013
La Trobe University
2013
Cancer Research UK Scotland Institute
2013
Abstract Heterogeneity of carcinoma-associated fibroblasts (CAF) has long been recognized, but the functional significance remains poorly understood. Here, we report distinction two CAF subtypes in oral squamous cell carcinoma (OSCC) that have differential tumor-promoting capability, one with a transcriptome and secretome closer to normal (CAF-N) other more divergent expression pattern (CAF-D). Both supported higher tumor incidence nonobese diabetic/severe combined immunodeficient (NOD/SCID)...
Background Cancer‐associated fibroblasts ( CAF s) were shown to be important for tumour progression in head and neck squamous cell carcinomas HNSCC s). Their heterogeneity lack of specific markers is increasingly recognized. Integrin α11 was recently expressed by s might serve as a marker. Aim To investigate integrin expression its correlation with the well‐known marker , alpha smooth muscle actin (α‐ SMA ), . Methods Fresh frozen FF ) formalin‐fixed paraffin‐embedded FFPE samples from...
Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and head neck squamous carcinoma (HNSCC). In current study, we further analyzed integrin α11 expression 14 tumor types by screening tissue array while using mAb 203E3, newly developed monoclonal antibody human α11. Different degrees were observed breast, ovary, skin, lung, uterus, stomach, pancreatic ductal adenocarcinoma (PDAC) tumors. Co-expression queries...
Altered expression of S100A16 has been reported in human cancers, but its biological role tumorigenesis is not fully understood. This study aimed to investigate the clinical significance and functional oral squamous cell carcinoma (OSCC) suppression. mRNA and/or protein levels were examined by quantitative RT-PCR immunohistochemistry whole- laser microdissected-specimens normal mucosa (NHOM, n = 65), dysplastic lesions (ODL, 21), OSCCs (n 132) positive cervical nodes 17). OSCC was for...
Utilizing nanoparticles as innovative theranostic agents for biomedical applications requires full control over the material’s properties to dictate their interactions within a biological environment. Owing its versatile surface chemistry and high biocompatibility, nanodiamond (ND) represents promising platform novel healthcare treatments. To ensure performance safety of NDs, behavior must remain unchanged upon administration, key challenge in nanomedicine. Recently, zwitterionic...
Utilizing nanoparticles as innovative theranostic agents for biomedical applications requires full control over the material’s properties to dictate their interactions within a biological environment. Owing its versatile surface chemistry and high biocompatibility, nanodiamond (ND) represents promising platform novel healthcare treatments. To ensure performance safety of NDs, behavior must remain unchanged upon administration, key challenge in nanomedicine. Recently, zwitterionic...
Malignant melanoma is the most aggressive type of skin cancer and closely associated with development brain metastases. Despite treatment, prognosis has traditionally been poor, necessitating improved therapies. In melanoma, mitogen activated protein kinase phosphoinositide 3-kinase signaling pathways are commonly altered, therapeutically inhibiting one often upregulates other, leading to resistance. Thus, combined treatment targeting both a promising strategy overcome this. Here, we studied...
Melanoma has the highest propensity of all cancers to metastasize brain with a large percentage late-stage patients developing metastases in central nervous system (CNS). It is well known that metastasis establishment, cell survival, and progression are affected by tumour-host interactions where changes host cellular compartments likely play an important role. In this context, miRNAs transferred tumour derived extracellular vesicles (EVs) have previously been shown create favourable...
Micro-RNAs (miRs) are emerging as important players in carcinogenesis. Their stromal expression has been less investigated part due to lack of methods accurately differentiate between tumor compartments. This study aimed establish a robust method for dual visualization miR and protein (pan-cytokeratin) by combining chromogen-based situ hybridization (ISH) immunohistochemistry (IHC), apply it investigate miR204 putative prognostic biomarker oral squamous cell carcinoma (OSCC). Four different...
This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or nDP and physisorbed BMP-2 (nDP-PHY) enhance osteoinductivity. Culturing early neoplastic dysplastic keratinocytes (DOK(Luc)) on modified reduced significantly their subsequent sphere formation ability decreased cells' proliferation in supra-basal layers vitro 3D oral mucosa (3D-OT) when compared DOK(Luc) previously...
Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation CAFs oral squamous cell carcinoma (OSCC) and its effects on their phenotype invasion adjacent OSCC cells. Expression was first investigated lesions (n = 53) OSCC-derived 15). MiR-138 mimics inhibitors were used functionally the role CAF resulting change ability support invasion. showed marked heterogeneity both tissues cultured...
Melanomas have a high potential to metastasize the brain. Recent advances in targeted therapies and immunotherapies changed therapeutical landscape of extracranial melanomas. However, few patients with melanoma brain metastasis (MBM) respond effectively these treatments new therapeutic strategies are needed. Cabozantinib is receptor tyrosine kinase (RTK) inhibitor, already approved for treatment non-skin-related cancers. The drug targets several proteins that known be dysregulated anti-tumor...
Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative The purpose of this study was to establish an experimental model precise noninvasive evaluation tumorigenic potential microenvironmental cancer.Bioluminescence chosen image tumor formation. Early neoplastic oral keratinocyte (DOK) cells were luciferase-transduced (DOK(Luc) ), then tested nonobese diabetic severe combined immunodeficient IL2rγnull...
Although several markers have been used for enrichment of cells with stem cell-like properties in oral squamous cell carcinoma (OSCC), isolation a pure subpopulation is still challenging task. Normal and esophageal keratinocyte previously isolated using the low-affinity nerve growth factor receptor p75NTR.To investigate potential p75NTR as marker identification cancer properties.Subpopulations high or low expression were sorted from OSCC-derived compared sphere/colony formation, vivo tumor...
Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate dysregulation cancer-associated fibroblasts (CAFs) oral squamous cell carcinoma (OSCC). Methodology: CAF and normal (NOFs) were isolated from biopsies OSCC patients healthy individuals after informed consent grown 3D collagen gels. Total RNA was extracted. Global expression profiled using Illumina version 2 panels. The functional impact altered miR-204 their...
Utilization of nanoparticles as innovative theranostic agent for various biomedical applications requires full control over the materials properties to dictate their interactions and effects within a biological environment. Owing its versatile surface chemistry high biocompatibility, nanodiamond (ND) represents an ideal platform paving way revolutionary treatments in healthcare. To ensure performance safety NDs, it is crucial that behavior remain unaffected upon administration, which...
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