A5042173536- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Extracellular vesicles in disease
- Pituitary Gland Disorders and Treatments
- Telomeres, Telomerase, and Senescence
- Tryptophan and brain disorders
- melanin and skin pigmentation
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Sexual Differentiation and Disorders
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Cell Adhesion Molecules Research
- Myasthenia Gravis and Thymoma
- Estrogen and related hormone effects
- Apelin-related biomedical research
- Biochemical and Structural Characterization
- Glioma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric Pain Management Techniques
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
- Circular RNAs in diseases
University of Luxembourg
2017-2024
Université Sorbonne Nouvelle
2015
Sorbonne Université
2015
Université de Rouen Normandie
2012-2015
Inserm
2012-2015
Institute for Research and Innovation in Biomedicine
2013-2015
Différenciation et Communication Neuronale et Neuroendocrine
2015
Bilateral macronodular adrenal hyperplasia is a rare cause of primary Cushing's syndrome. In this form hyperplasia, hypersecretion cortisol suppresses the release corticotropin by pituitary corticotrophs, which results in low plasma levels. Thus, disease has been termed corticotropin-independent hyperplasia. We examined abnormal production these hyperplastic glands.We obtained specimens tissue from 30 patients with disease. The precursor proopiomelanocortin and expression were assessed means...
Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic events such as invasion, metabolic reprogramming, epithelial-mesenchymal transition, metastasis and resistance to therapy, all favouring cancer progression. Small extracellular vesicles (EV) shuttle various cargos (proteins, miRNAs, DNA others). Tumour-derived EVs can be taken up by neighbouring or distant cells in the tumour microenvironment, thus facilitating intercellular communication. The quantity...
Melanoma has the highest propensity of all cancers to metastasize brain with a large percentage late-stage patients developing metastases in central nervous system (CNS). It is well known that metastasis establishment, cell survival, and progression are affected by tumour-host interactions where changes host cellular compartments likely play an important role. In this context, miRNAs transferred tumour derived extracellular vesicles (EVs) have previously been shown create favourable...
Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown be reversible and cells escaping senescence further enhance the aggressiveness cancers. Chemicals specifically targeting senescent cells, so-called senolytics, constitute a promising avenue for improved treatment in combination with targeted therapies. Understanding how evade is needed optimise clinical benefits this therapeutic approach. Here we characterised response...
Adrenal mast cells can stimulate aldosterone secretion through the local release of serotonin (5-HT) and activation 5-HT4 receptor (5-HT4). In aldosterone-producing adenomas (APAs), is overexpressed administration agonists to patients with APA increases plasma levels. These data well-documented role in tumorigenesis suggest that may be involved pathophysiology APA.The study aimed at investigating occurrence a series tissues examine influence on secretion.The APAs was investigated by...
Early life stress (ELS) leads to a permanent reprogramming of biochemical response cascades that may also be relevant for the processing chronic pain states such as neuropathy. Despite clinical evidence, little is known about ELS-related vulnerability neuropathic and possibly underlying etiology. In framework experimental studies aimed at investigating respective relationships we used established ELS model maternal separation (MS). Rat dams neonates were separated 3 h/day from post-natal day...
The cumulative and match/mismatch hypotheses of stress are still under discussion regarding the effects early life (ELS) on vulnerability or resilience to psychopathology. In this context, an additional in later (second hit) often leads stress-related disorders that frequently include comorbid pain states. We previously observed maternal separation (MS), a model ELS, reduces neuropathic inflammatory rats. present study, we investigated stressor pain. Sprague Dawley pups were divided into 4...
Hirsutism induced by hyperandrogenism can be associated with polycystic ovary syndrome, 21-hydroxylase (OH) deficiency or androgen-secreting tumors, including ovarian and adrenal tumors. Adrenal tumors are frequently malignant. oncocytomas represent rare causes of hyperandrogenism. The aim the study was to investigate steroidogenic enzyme expression steroid secretion in an oncocytoma a young woman presenting hirsutism. Hyperandrogenism diagnosed on basis elevated plasma Δ4-androstenedione...
Background Neutrophils are an important source of pro-inflammatory and immunomodulatory cytokines. This makes neutrophils efficient drivers interactions with immune non-immune cells to maintain homeostasis modulate the inflammatory process by notably regulating release Ca 2+ -dependent regulatory mechanism encompassing cytokine secretion not still identified. In this context, we propose define new insights on role -binding proteins S100A8/A9 miRNA-132-5p, which was identified as a regulator...
Abstract Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown be reversible and cells escaping senescence further enhance the aggressiveness cancers. Together with targeted therapeutics, senolytics, specifically targeting senescent cells, constitute a promising avenue for improved treatments. Understanding how evade is needed optimise clinical benefits this therapeutic approach. Here we characterised response three...
Abstract Melanoma has a high propensity for brain metastasis, occurring in 40% of late-stage patients. The progression secondary tumors the depends on support surrounding microenvironment, emphasizing importance modulating neighboring cells successful metastasis. Tumor-derived extracellular vesicles (EVs) play crucial role creating pre-metastatic niche tumor growth by transferring proteins, RNA, and DNA. This study aims to explore involvement melanoma metastasis (MBM)-derived EVs MBM...