A5003294854- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Vestibular and auditory disorders
- Facial Nerve Paralysis Treatment and Research
- Ophthalmology and Eye Disorders
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Glioma Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Cardiovascular and Diving-Related Complications
- Microtubule and mitosis dynamics
- Multiple Sclerosis Research Studies
- Spinal Cord Injury Research
- Myofascial pain diagnosis and treatment
- Myasthenia Gravis and Thymoma
- Neurological diseases and metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- RNA regulation and disease
- Sarcoma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Hereditary Neurological Disorders
- School Health and Nursing Education
Haukeland University Hospital
2005-2023
Clinical Trial Investigators
2023
University of Bergen
2007-2014
Norwegian Water
1985-2009
The optimal treatment for sporadic vestibular schwannoma (VS) is highly controversial. To date, the majority of studies comparing modalities have focused on a narrow scope technical outcomes including facial function, hearing status, and tumor control. Very few publications investigated health-related quality life (HRQOL) differences between individual groups, none used disease-specific HRQOL instrument.All patients with small- to medium-sized VSs who underwent primary microsurgery,...
OBJECTIVE To conduct a prospective, open, nonrandomized study of treatment-associated morbidity in patients undergoing microsurgery or gamma knife radiosurgery (GKRS) for vestibular schwannomas. METHODS Ninety-one with schwannomas maximum tumor diameter 25 mm the cerebellopontine angle were treated according to prospective protocol either by GKRS (63 patients) open (28 using suboccipital approach. Primary end points included hearing function, Gardner-Robertson scale, and facial nerve...
Material and Results: A retrospective study of 219 VS patients, non-NF 2, mean obs. time: 5.8 yrs. Tumors > 30 mm (n = 30) excluded. There were 189 patients eligible for comparative evaluation. SF-36 Glasgow Benefit Inventory (GBI) questionnaires sent together with a information letter to the 168 living patients. GBI questions reflect general psychosocial health. mental health (MH) vitality (VT).
Importance Current guidelines for treating small- to medium-sized vestibular schwannoma recommend either upfront radiosurgery or waiting treat until tumor growth has been detected radiographically. Objective To determine whether provides superior volume reduction a wait-and-scan approach schwannoma. Design, Setting, and Participants Randomized clinical trial of 100 patients with newly diagnosed (<6 months) unilateral maximal diameter less than 2 cm in the cerebellopontine angle as...
Abstract OBJECTIVE The aim of the present study was to characterise relation between quality life (QOL) and four major complaints (hearing loss, tinnitus, vertigo unsteadiness) caused by unilateral vestibular schwannoma (versus) in a cohort well-characterised untreated patients. METHODS One hundred ninety-nine consecutive patients (91 men, 108 women) with mean age 56.9 years were studied prospectively during 4-year period 2001–2004. average time span from symptom onset radiological diagnosis...
There are few reports about the course of vestibular schwannoma (VS) patients following gamma knife radiosurgery (GKRS) compared with conservative management (CM). In this study, we present prospectively collected data 237 unilateral VS extending outside internal acoustic canal who received either GKRS (113) or CM (124).The aim was to measure effect natural on tumor growth rate and hearing loss. Secondary end points were postinclusion additional treatment, quality life (QoL), symptom...
Objectives/Hypothesis To evaluate outcomes of salvage surgery for vestibular schwannoma (VS) that failed primary stereotactic radiosurgery (SRS). Methods Case‐control study 37 patients who underwent surgical resection sporadic VS following prior SRS at two tertiary academic referral centers between 2003 and 2015. A cohort nonirradiated control subjects, matched according to tumor size, age, treatment center, were used as comparison. Results Thirty‐seven included. The median time from...
OBJECTIVE Vestibular schwannoma (VS) is a benign tumor with associated morbidities and reduced quality of life. Except for mutations in NF2, the genetic landscape VS remains to be elucidated. Little known about effect Gamma Knife radiosurgery (GKRS) on genome. The aim this study was characterize occurring identify new genes signaling pathways important development VS. In addition, authors sought evaluate whether GKRS resulted an increase number mutations. METHODS Forty-six sporadic VSs,...
Previous studies have shown that vertigo is the most powerful negative predictor of quality life in patients with vestibular schwannomas, but variability symptom severity still poorly understood. We wanted to find out whether could be related objective parameters such as tumor size, location, nerve function, hearing, and postural stability untreated schwannomas.Baseline data from prospective cohort study.Tertiary referral center.Four hundred thirty-four consecutive unilateral VS diagnosed on...
Abstract Purpose Standard surgical treatment for symptomatic cervical disc disease has been discectomy and fusion, but the use of arthroplasty, designed to preserve motion, increased, most studies report clinical outcome in its favor. Few these trials, however, blinded patients. We, therefore, conducted Norwegian Cervical Arthroplasty Trial, present 2-year after arthroplasty or fusion. Methods This multicenter trial included 136 patients with single-level disease. The were randomized...
Heterotopic ossification is a phenomenon in cervical arthroplasty. Previous reports have mainly focused on various semiconstrained devices and only few publications around that are nonconstrained. The purpose of this study was to assess the occurrence heterotopic nonconstrained device how it affects clinical outcome 2 years after surgery. Thirty-seven patients were included from larger cohort randomized controlled trial (NORCAT) which compared single-level arthroplasty with fusion. assessed...
To assess the effects of deep saturation dives on pulmonary function, static and dynamic lung volumes, transfer factor for carbon monoxide (T1CO), delta-N2, closing volume (CV) were measured before after eight to pressures 3.1-4.6 MPa. The atmospheres helium-oxygen mixtures with partial oxygen 40-60 kPa. durations 14-30 days. Mean rate decompression was 10.5-13.5 kPa/hour. A total 43 divers examined, six whom took part in two dives, others one only. Dynamic volumes did not change...
ABSTRACT— Two patients, in whom visual disturbance (Case 1) and sudden hemiparalysis due to a hemorrhagic lesion 2) had led craniotomy histological diagnosis of giant cell glioblastoma, each an unexpectedly long survival period 7 9 years, respectively. Radiologically, the tumours were well demarcated, but without any distinguishing features, by comparison with glioblastomas general. The tumours, great extent, consisted cells large, bizarre multiple nuclei. highly pleomorphic displayed strong...
OBJECTIVE Patient-reported outcomes are increasingly used in studies of vestibular schwannoma (VS); however, few have examined self-evaluated facial nerve function and its relation to physician-reported outcomes. The primary objective this study was compare patient self-evaluations disability with physician-evaluated status a healthy control group. second provide insight into the controversial subject optimal initial management small- medium-sized VSs; consequently, authors compared...
OBJECTIVE The aim of the present study was to characterise relation between quality life (QOL) and four major complaints (hearing loss, tinnitus, vertigo unsteadiness) caused by unilateral vestibular schwannoma (versus) in a cohort well-characterised untreated patients. METHODS One hundred ninety-nine consecutive patients (91 men, 108 women) with mean age 56.9 years were studied prospectively during 4-year period 2001–2004. average time span from symptom onset radiological diagnosis 4.2...
Intramedullary spinal cord tumours are rare and account for about 2-4% of primary CNS tumours. Ependymomas astrocytomas most frequent. The aim this study was to evaluate the long-term neurological outcome, quality life (QoL), survival, need additional treatment frequency neuropathic pain in a patient group treated at tertiary university hospital.Retrospective descriptive 52 survivors with intramedullary or filum consenting participate study. Fifty-six operations were performed 48 patients....