A5088646325- Glioma Diagnosis and Treatment
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Schizophrenia research and treatment
- Mesenchymal stem cell research
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Bipolar Disorder and Treatment
- Virus-based gene therapy research
- Microtubule and mitosis dynamics
- Nanoplatforms for cancer theranostics
- Antimicrobial Peptides and Activities
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- Virology and Viral Diseases
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
University of Bergen
2008-2024
Haukeland University Hospital
2021-2024
Abstract Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell-based therapies of injury degenerative diseases. However, extensive expansion ex vivo is a prerequisite obtain the numbers required human therapy protocols. Recent studies indicate that may contribute cancer development progression either acting as cancer-initiating or through interactions with...
Abstract It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result genetic drift the cancer cells. In addition, long‐term cultures harbor risk of cross‐contamination with other lines. The consequences have major impact experimental results obtained various laboratories, where lines no longer reflect original tumors they are supposed to represent. Much neglected scientific community close monitoring by regular phenotypic...
Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer cells with an immature stem-like phenotype hypothesised play role in radioresistance. Since the progenitor marker neuron-glial-2 (NG2) has been shown regulate several aspects GBM progression experimental systems, we that its expression would influence patients....
Background: Several studies have found an association between elevated neutrophil count or neutrophil-to-lymphocyte ratio (NLR) in peripheral blood from patients with schizophrenia. The etiology behind this effect is unknown, and it unclear if changes NLR may be induced by antipsychotics these parameters relate to the diagnosis symptoms of purpose scoping review was map research that explores association, identify gaps current knowledge base. Method: work conducted accordance established...
A NOD/Scid mouse expressing enhanced green fluorescent protein (eGFP) is described, in which human and tumors marked with red can be established vivo, both at subcutaneous orthotopic locations. Using light microscopy as well multiphoton confocal techniques, we visualized detail the intricate colocalization of tumor host cells situ. Moreover, using fluorescence-activated cell sorting (FACS), were able to completely separate from cells, thus providing a system for detailed cellular molecular...
Abstract Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients with SCZ or BD versus healthy controls (HC). analyzed microarray-based global gene expression data whole from a cohort ( N = 329), 203) HC 189). In total, 65 genes were significantly differentially expressed 125 BD, as compared HC, similar ratio up- downregulated both...
Oligodendroglioma poses a biological conundrum for malignant adult human gliomas: it is tumor type that universally incurable patients, and yet, only few of the tumors have been established as cell populations in vitro or intracranial xenografts vivo. Their survival, thus, may emerge within specific environmental context. To determine fate oligodendroglioma an experimental model, we studied development anaplastic after implantation into enhanced green fluorescent protein (eGFP) positive...
Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity the immune system is seen both depression and schizophrenia. We aimed to uncover depressive trajectories a sample 144 adult individuals with disorders followed for one year, order identify possible cytokine profile differences. Patients were assessed longitudinally Positive Negative Syndrome Scale (PANSS) Calgary Schizophrenia (CDSS), where score above 6 predicts depression. The serum...
Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts inflammation markers. Here, we investigate whether time of draw treatment psychiatric medications are related to estimated WBC proportions between SCZ cases controls. DNA methylation data from whole was used estimate six subtypes WBCs patients (n = 333) 396). We tested the association case-control status cell-type neutrophil-to-lymphocyte ratio (NLR) 4 models: with/without adjusting for...
Suicide is a common cause of death in all phases schizophrenia spectrum disorder, particularly the youngest patients. Clinical measures have demonstrated limited value suicide prediction, spurring search for potential biomarkers. The causes suicidal behaviour are complex, but immune system seems to be involved as it reflects or even mental suffering. We aimed identify cytokines with associations suicidality sample patients symptoms active psychosis. Patients disorder (N = 144) participating...
Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented experimental models vitro. amplification, for example, occurs 40 to 50% GBM, yet, is rarely preserved cell cultures derived from tumors. To analyze fate amplified mutated cells culture, we followed development over time xenografts nude rats enriched tumor with patient samples mutations, serum monolayer spheroid suspension under free conditions. We observed conditions,...
Abstract Alpha defensins are anti-microbial peptides of the innate immune system. The defensin A1 and A3 genes located in a repeat array variable copy number (the DEFA1A3 locus) encode human neutrophil 1, 2 3. possibility that variation (CNV) may be associated with infection susceptibility autoimmune pathology motivated study CNV across populations. We enhanced two existing methods (one qPCR-based one sequencing-based) to enable estimation discriminates between DEFA1 DEFA3 genes. used these...