Infiltrating low-grade gliomas (LGG; WHO grade 2) typically present with seizures in young adults. LGGs grow continuously and usually transform to higher of malignancy, eventually causing progressive disability premature death. The effect up-front surgery has been controversial the impact molecular biology on is unknown. We now long-term results upfront surgical resection compared watchful waiting light recently established markers.Population-based parallel cohorts were followed from two...

Background Increasing prevalence of antibiotic resistance especially to clarithromycin and metronidazole has been observed in Helicobacter pylori (H . pylori) Aim To characterize the antimicrobial pattern H before after treatment a cohort patients accumulated over period 15 years an unsuccessful eradication had given comparing sensitivity data from with newly diagnosed infection. A specific objective was look for levofloxacin. Material methods Total 50 infection treated omeprazole...

Abstract DNA methylation has been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and development of ulcerative colitis (UC). Changes correlated gene expression patient samples inactive UC might reveal possible regulatory features important for further treatment options UC. Targeted bisulfite sequencing whole transcriptome were performed on mucosal biopsies from patients active (UC, n = 14), (RM, 20), non-IBD which served as controls (NN,...

Biological therapy for inflammatory bowel disease is efficient in many cases but not all. The underlying molecular mechanisms behind non-response to biological are poorly described. Therefore, we aimed characterize the mucosal cytokine transcript profile non-immunogenic, non-responder patients with adequate trough level.Patients ulcerative colitis (UC) (n = 21) and Crohn's (CD) 12) (anti-tumor necrosis factor (TNF) or vedolizumab) were included. Reference groups A: untreated UC CD at debut...

Background Anti-tumour necrosis factor (TNF) agents play a pivotal role in the treatment of moderate to severe ulcerative colitis (UC), and yet, no international consensus on when discontinue therapy exists. Objective The aim this study is long-term performance algorithm repeated intensified induction with infliximab (IFX) remission, followed by discontinuation patients UC. Patients methods UC were enroled an open prospective design. following was implemented: (a) remission (Ulcerative...

Abstract Background There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim this study was to explore a comprehensive data set identify and validate predictors the first year following Methods Treatment naive-patients with were included initial diagnosis from 2004 2014, followed by validation 2014 2018. Patients treated according guidelines standard step-up regime. categorized treatment level necessary achieve remission: mild,...

Due to the lack of clinical, immunologic, genetic, and laboratory markers predict remission in ulcerative colitis (UC) without relapse, there is no clear recommendation regarding withdrawal therapy. Therefore, this study was investigate if transcriptional analysis together with Cox survival might be able reveal molecular that are specific for duration outcome. Mucosal biopsies from patients active treatment-naïve UC healthy control subjects underwent whole-transcriptome RNA-seq. Principal...

Background and aims Patients that have failed therapy for Helicobacter pylori (H. pylori) infection are incompletely characterized. The aim of this study was to characterize a H. treatment resistant cohort compared the cohorts newly diagnosed, earlier eradicated non-infected. Material methods were selected from routine referrals Endoscopy units at three different Norwegian hospitals. In all four cohorts, gastric biopsies scored according Sydney classification, symptoms Gastrointestinal...

Abstract Background The long-term outcomes of Ulcerative colitis (UC) after discontinuation biological therapy are largely unknown. There is also a lack accurate and validated markers that can predict outcome withdrawal accurately. aims this study were to describe the in UC patients following cessation anti-TNF explore potential biomarkers as an approach towards precision medicine. Methods Seventy-five with moderate severe treated remission anti-tumor necrosis factor (TNF) included study....

One hundred and eight patients with endoscopically proven duodenal ulcers were randomly allocated to treatment cimetidine, either 400mg twice daily or 800 mg at night for 4 8 weeks in a double-blind study. There was no significant difference between the healing rates of two groups. Thus, 45 52 (87%) healed on cimetidine 43 51 (84%) after weeks' treatment. The corresponding (98%) 50 (98%). intensity pain decreased more rapidly group treated night. These results indicate that is as good 400...

Background Moderate to severe ulcerative colitis (UC) is generally treated with a step-up algorithm from 5-aminosalicylic acid (5-ASA) biological agents. There no general recommendation if or when de-escalate discontinue therapy. In this study, we performed therapy anti-tumor necrosis factor (TNF) treatment endoscopic remission followed by discontinuation of This 13- year follow-up study for algorithm. Aim aimed assess whether the outlined above influences UC phenotype toward milder form and...

Abstract Background There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim this study was to explore a comprehensive data set identify and validate predictors the first year following Methods Treatment naive-patients with were included initial diagnosis from 2004-2014, followed by validation 2014-2018. Patients treated according guidelines standard step-up regime. categorized treatment level necessary achieve remission: mild,...

Abstract Epigenetic changes, like DNA methylation, have been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and development of ulcerative colitis (UC). Changes methylation correlated gene expression patient samples inactive UC might reveal possible regulatory features important for further treatment options UC. Bisulfite sequencing whole transcriptome were performed on mucosal biopsies from patients active (UC, n = 14), (RM, 20), non-IBD...

Abstract Background There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim this study was to explore a comprehensive data set identify and validate predictors the first year following Methods Treatment naive-patients with were included initial diagnosis from 2004-2014, followed by validation 2014-2018. Patients treated according guidelines standard step-up regime. categorized treatment level necessary achieve remission: mild,...

Abstract Background There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim this study was to explore a comprehensive data set identify and validate predictors the first year following Methods Treatment naive-patients with were included initial diagnosis from 2004–2014, followed by validation 2014–2018. Patients treated according guidelines standard step-up regime. categorized treatment level necessary achieve remission: mild,...

Abstract Background Biological therapy for ulcerative colitis (UC) such as anti-TNF have shown high efficacy in achieving remission. There is a lack of information about the long-term outcomes after biologic withdrawal and validated clinical, immunologic, genetic or laboratory markers that can predict outcome accurately. The aims this study were to describe discover potential biomarkers remission an approach towards personalized medicine. Methods 75 patients with moderate severe UC treated...