A5044145393- Cervical Cancer and HPV Research
- Genital Health and Disease
- Hepatitis B Virus Studies
- Sarcoma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Molecular Biology Techniques and Applications
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Vascular Tumors and Angiosarcomas
- Reproductive tract infections research
- Immune Cell Function and Interaction
- Endometrial and Cervical Cancer Treatments
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- European and International Law Studies
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
University Hospital of North Norway
2016-2025
Stellenbosch University
2023
UiT The Arctic University of Norway
1996-2022
Tromsø research foundation
2020
Institute of Medical Biology
2012
Posten (Norway)
2010
Centre for Arctic Gas Hydrate, Environment and Climate
1996
The quadrivalent human papillomavirus (qHPV) vaccine prevented HPV type-related infection and disease in young women the 4-year FUTURE II efficacy study (NCT00092534). We report long-term effectiveness immunogenicity at end of 14 years follow-up after enrollment II.Young (16-23 age) from Denmark, Iceland, Norway, Sweden who received three qHPV doses during randomized, double-blind, placebo-controlled base were followed for an additional ≥10 through national registries. Tissue samples...
In recent years, microRNAs (miRNAs) have been found to play an essential role in tumor development. lung tumorigenesis, targets and pathways of miRNAs are being revealed, further translational research this field is warranted. MiR-155 one the most consistently involved various neoplastic diseases. We aimed investigate prognostic impact multifunctional miR-155 non-small cell cancer (NSCLC) patients. Tumor tissue samples from 335 resected stage I IIIA NSCLC patients were obtained microarrays...
Purpose The purpose of this study was to clarify the prognostic significance lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers potentially curable STS should guide therapy after surgical resection. immune status at time resection may be important, but tumor infiltrating lymphocytes is controversial as system has conflicting roles during cancer development. Experimental Design Tissue microarrays from 249 patients with were constructed duplicate cores viable and...
The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence undiagnosed adult CD and examine GFD CD. In total, 12,981 adults participated in health study Tromsø, Norway. Participants with increased levels anti-tissue transglutaminase-2 IgA or anti-deamidated gliadin peptide IgG were invited undergo gastroduodenoscopy both histological immunohistochemical examination small-bowel biopsies. previously...
Abstract BACKGROUND: Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor‐A (VEGF‐A) considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular miR‐126 has related to angiogenesis and regulation VEGF‐A. The authors aimed investigate prognostic impact its co‐expression VEGF‐A nonsmall cell lung cancer (NSCLC) patients. METHODS: Tumor tissue samples from 335 resected stage I IIIA NSCLC patients...
Cervical cancer can be prevented by early detection and treatment for precancerous lesions. Since 1995, there has been a national cervical screening program in Norway, where women aged 25-69 years are recommended to take Pap smears every three years. There 17 cytology laboratories covering population of 5 million people. The rate abnormalities varies from laboratory laboratory. We wanted investigate the accuracy diagnoses four different pathologists at hospitals Norway.One hundred (20...
Abstract Background This study addresses whether existing specific transcriptional profiles can improve and support the current status of definition ulcerative colitis (UC) remission apart from endoscopic, histologic, laboratory scoring systems. For that purpose, a well-stratified UC patient population in was compared to active control patients investigated by applying next-generation technology RNA-Seq. Methods Mucosal biopsies (n = 14), with healthy patientss 16) underwent...
A long-term follow-up (LTFU) of the nine-valent human papillomavirus (9vHPV) vaccine efficacy study in young women aged 16–26 years was initiated to evaluate if effectiveness for up 14 post-vaccination will remain above 90%. Vaccine is measured as percent reduction incidence HPV16/18/31/33/45/52/58-related high-grade cervical dysplasia LTFU cohort relative expected a similar unvaccinated cohort. We report an interim analysis 8 post-vaccination. Overall, 2029 participants from Denmark,...
Background: Human papillomavirus (HPV), the most prevalent sexually transmitted infection globally, is a key risk factor for high-grade cervical lesions and cancer. Since 2009, HPV vaccination has been part of national immunization program girls in 7th grade Norway (women born 1997 later). This study aimed to assess impact on incidence precursors (CIN2+) among women aged 20–25 Troms Finnmark over 15-year period. Materials Methods: In this time series study, we analyzed screening data from...
Background/Objectives: Human papillomavirus (HPV) is the primary cause of high-grade cervical lesions and cancer worldwide. In Norway, HPV vaccination was introduced in 2009 for seventh-grade girls extended through a catch-up program from 2016 to 2019 women born between 1991 1996. This study evaluates impact on incidence Troms Finnmark. Methods: We analyzed data 40,617 aged 26 30 who underwent screening 2023 Finnmark, including 1850 with (CIN2+) biopsy. Using linear regression, we assessed...
Background Human papillomavirus (HPV) testing is included in the cervical cancer screening program triage of women with equivocal (ASC-US) or low-grade (LSIL) cytological lesions. These have an increased risk for developing high grade dysplasia and (CIN2+) compared to normal cytology. However, order avoid unnecessary follow-up, as well overtreatment, a positive predictive value (PPV) test important. Methodology/Principal Findings The HPV PreTect HPV-Proofer, detecting E6/E7 mRNA from types...
Abstract Background HPV self-sampling has been widely supported by the scientific community following a strong body of literature on subject. Self-sampling is important in cervical cancer screening as it shown to improve participation. It well documented that HPV-testing proven superior cytology with regards sensitivity detection CIN and cancer. The value self-collected samples reliant quality molecular testing performed, patients’ preference sampling procedure compliance follow up positive...
Background In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important avoid unnecessary diagnostic therapeutic procedures whereas a low risk high-grade disease among assures safety. Materials Methods At University Hospital North cytology HPV mRNA PreTect HPV-Proofer,...
Purpose The purpose of this study is to clarify the prognostic significance expression Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas (STS). Optimised treatment STS requires better identification high risk patients who will benefit from adjuvant therapy. has not been sufficiently investigated. Experimental Design Tissue microarrays 193 were constructed duplicate cores viable representative neoplastic tumor areas. Immunohistochemistry was used evaluate Skp2. Results In univariate...
The purpose of this study was to clarify the prognostic significance peritumoral lymphocyte infiltration in capsule soft tissue sarcomas (STS). Multiple observations preclinical and clinical studies have shown that immune system has a role controlling tumor growth progression. Prognostic markers potentially curable STS should guide therapy after surgical resection. status at time resection may be important, but lymphocytes is unknown.Tissue microarrays from 80 patients with were constructed...
Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology disease are not fully understood we therefor aim in this study to identify important pathophysiological features UC from proteomics data.Colon mucosa biopsies inflamed tissue untreated patients at diagnosis healthy controls were obtained during colonoscopy. Quantitative protein data was acquired by bottom-up furthermore processed with MaxQuant. quantitative proteome analyzed Perseus...
Background Increasing prevalence of antibiotic resistance especially to clarithromycin and metronidazole has been observed in Helicobacter pylori (H . pylori) Aim To characterize the antimicrobial pattern H before after treatment a cohort patients accumulated over period 15 years an unsuccessful eradication had given comparing sensitivity data from with newly diagnosed infection. A specific objective was look for levofloxacin. Material methods Total 50 infection treated omeprazole...
In non-gastrointestinal stromal tumor soft tissue sarcoma (non-GIST STS) optimal treatment is surgery with wide resection margins. Vascular endothelial growth factors (VEGFs) and receptors (VEGFRs) are known to be key players in the initiation of angiogenesis lymphangiogenesis. This study investigates prognostic impact VEGFs VEGFRs non-GIST STS non-wide margins.Tumor samples from 249 patients were obtained microarrays constructed for each specimen. Immunohistochemistry was used evaluate...
In Norway, women with low-grade squamous intraepithelial lesions (LSIL) are followed up after six months in order to decide whether they should undergo further follow-up or be referred back the screening interval of three years. A high specificity and positive predictive value (PPV) triage test is important avoid unnecessary diagnostic therapeutic procedures.At University Hospital North repeat cytology HPV mRNA PreTect HPV-Proofer, detecting E6/E7 from types 16, 18, 31, 33 45, used ASC-US...
In Norway, repeat cytology and HPV testing comprise delayed triage of women with minor cytological lesions. The objective this study was to evaluate DNA mRNA in an ASC-US/LSIL diagnosis.We used cytology, (Cobas 4800) (PreTect HPV-Proofer) follow up 311 aged 25-69 years index cytology.Of scheduled for secondary screening, 30 (9.6%) had ASC-H/HSIL at 281 (90.4%) or normal cytology. test positive 92 (32.7%) instances, 37 (13.2%) were positive. Of the 132 repeated ASC-US/LSIL, we received...
Background: Mucosal healing is proposed as treat-to-target in ulcerative colitis (UC), even though the definition of mucosal remains contested it has been suggested to be assessed by either endoscopy, histology or both. However, all definitions require an endoscopic evaluation mucosa. As endoscopies are invasive and uncomfortable patient we aimed calibrate noninvasive predictors inflammatory status defined both endoscopy histology.Methods: UC patients (n = 106) undergoing a...
OBJECTIVES: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption mucosal wound healing may lead to severe complications including fibrosis. This study examined gene expression process UC with a special focus on known mediators METHODS: Endoscopic biopsies from patients acute, moderate were analyzed quantitative polymerase chain reaction array for 84 genes involved fibrosis pathways. All treated infliximab (anti– tumor necrosis factor). Biopsies taken...
Background: A plethora of data supports HPV-based screening to be the preferred strategy for cervical cancer prevention. The shift a more sensitive first-line test brings need effective triage up discussion. Currently, most algorithms apply cytology as HPV-DNA positive women. This study compared performance 7-type HPV-mRNA cytology. Methods: From 1 January 2019 until 31 December 2021, samples from 58,029 women were examined at University Hospital North Norway. total 30.5% (17,684/58,029)...