A5075509848- Cervical Cancer and HPV Research
- Genital Health and Disease
- Hepatitis B Virus Studies
- Polyomavirus and related diseases
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- Reproductive tract infections research
- Viral-associated cancers and disorders
- Multiple Sclerosis Research Studies
- Molecular Biology Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Full-Duplex Wireless Communications
- Semantic Web and Ontologies
- Animal Virus Infections Studies
- Genomics and Rare Diseases
- Acute Lymphoblastic Leukemia research
- Nonmelanoma Skin Cancer Studies
- Plant Virus Research Studies
- Parvovirus B19 Infection Studies
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Mycobacterium research and diagnosis
Karolinska Institutet
2013-2022
Karolinska University Hospital
2017-2021
Skåne University Hospital
2013-2020
Lund University
2013
A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) study to evaluate association between tobacco smoking risk cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) invasive cancer (ICC). At baseline, participants completed a questionnaire provided blood samples. During mean follow-up time 9 years, 261 ICC cases 804 CIN3/CIS reported. In nested case-control study, baseline sera 609 1,218 matched controls...
The quadrivalent human papillomavirus (qHPV) vaccine prevented HPV type-related infection and disease in young women the 4-year FUTURE II efficacy study (NCT00092534). We report long-term effectiveness immunogenicity at end of 14 years follow-up after enrollment II.Young (16-23 age) from Denmark, Iceland, Norway, Sweden who received three qHPV doses during randomized, double-blind, placebo-controlled base were followed for an additional ≥10 through national registries. Tissue samples...
The long-term effectiveness of the quadrivalent human papillomavirus (qHPV) vaccine was assessed by monitoring combined incidence cervical intraepithelial neoplasia (CIN2, CIN3), adenocarcinoma in situ (AIS), and cancer related to HPV16 or HPV18.Women from Nordic countries Denmark, Iceland, Norway, Sweden who received a 3-dose regimen qHPV beginning FUTURE II (Females United Unilaterally Reduce Endo/Ectocervical Disease; V501-015, base study NCT00092534) are followed through different...
Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology has remained controversial mainly due to the lack of serological methods that can distinguish two viruses. A novel multiplex assay measuring IgG reactivity against immediate-early protein 1 from HHV-6A (IE1A) and (IE1B) was used a MS cohort (8742 persons with 7215 matched controls), pre-MS (478 individuals 476 controls) investigate this further. The response IE1A positively associated (OR = 1.55, p 9x10-22),...
This quadrivalent human papillomavirus (qHPV) (HPV6, -11, -16, and -18) vaccine long-term follow-up (LTFU) study is an ongoing extension of a pivotal clinical (FUTURE II) taking place in the Nordic region. The LTFU was designed to evaluate effectiveness, immunogenicity, safety qHPV (Gardasil) for at least 10 years following completion base study. current report presents immunogenicity data from testing samples year 5 visit (approximately 9 after vaccination). FUTURE II vaccination arm...
Immunosuppression involves an inability to control virus infections and increased incidence of virus-associated cancers. Some cancers without known viral etiology are also increased, but data on exactly which cancer forms has been inconsistent. To provide a reliable generalizable estimate, with high statistical power long follow-up time, we assessed risks using comprehensive, population-based registries in two different countries from immunosuppressed patient groups (solid organ transplant...
To evaluate prospectively the association between serological markers of selected infections, including HPV, and risk developing cervical cancer (CC) precancer, we performed a nested case–control study within European Prospective Investigation into Cancer Nutrition (EPIC) that included 184 cases invasive CC (ICC), 425 intraepithelial neoplasia (CIN) grade 3 or carcinoma in situ (CIS), 1,218 matched control women. At enrollment participants completed lifestyle questionnaires provided sera....
Background Infection with high-risk human papillomavirus (HPV) is causally related to cervical, vulvar and vaginal pre-invasive neoplasias cancers. Highly effective vaccines against HPV types 16/18 have been available since 2006, are currently used in many countries combination cervical cancer screening control the burden of cancer. We estimated overall age-specific incidence rate (IR) neoplasia Denmark, Iceland, Norway Sweden 2004–2006, prior availability vaccines, order establish a...
Prevalence of different HPV genotypes is changing after vaccination. The associated risks are needed for optimizing cervical cancer screening.To estimate type-specific prevalence, odds ratio (OR), and positive predictive value (PPV) cytological abnormalities, we determined 41 in samples from a population-based sample 8351 women aged 18-51 years before vaccination era (V501-033; NCT01077856).Prevalence HPV16 was 4.9% (95% CI: 4.4-5.5) with the PPV high-grade cytology 11.2%, OR 11.9 8.5-16.5)....
Objective The aim of this research is to implement and reliably evaluate primary human papillomavirus (HPV) screening in an established routinely running organised, large-scale population-based programme. Participants Resident women the Stockholm/Gotland region Sweden, aged 56–60 years were randomised either (1) with cervical cytology, HPV test triage low-grade cytological abnormalities (old policy) or (2) testing, cytology positives (new policy). Outcome evaluation was detection rate...
Biobanks are a critical resource for translational science. Recently, semantic web technologies such as ontologies have been found useful in retrieving research data from biobanks. However, recent has also shown that there is lack of about the administrative aspects These would be helpful to answer research-relevant questions what scope specimens collected biobank, curation status specimens, and contact information curators Our use cases include giving researchers ability retrieve key (e.g....
Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cancer in order assess the potential impact HPV vaccination. In four countries (Denmark, Norway, Sweden, Iceland), we collected consecutive series cancers (n = 639) precancerous lesions 1240) during 2004‐2006 before implementation vaccination subjected specimens standardized...
The effect of cervical screening on adenocarcinoma has been variable, possibly because the risk associated with precursor atypical glandular cells (AGC) is not well known. A cohort all 885 women in capital region Sweden AGC, a concomitant human papillomavirus (HPV) analysis, and histopathology was followed until 2019. Cumulative incidence proportions intraepithelial lesion grade 3 or worse (CIN3+) by HPV type determined 1-Kaplan-Meier estimates. Hazard ratios (HR) for CIN3+ invasive cancer...
Most cancer forms known to be caused by viruses are increased among the immunosuppressed, but several without established viral etiology also increased, notably nonmelanoma skin carcinoma (NMSC). We followed all 13,429 solid organ transplantation patients in Sweden for occurrence after transplantation. requested these tumor specimens and sequenced first 89 received (62 NMSCs, 27 other cancers). The sequences were analyzed based on two bioinformatics algorithms (paracel-blast (sensitive...
Background To enable incremental optimization of screening, regular reporting quality indicators is required. Aim report key and basic statistics about cervical screening in Sweden. Methods We collected individual level data on all cytologies, histopathologies, human papillomavirus tests invitations for Sweden during 2013–2016. Results There were over 2,278,000 samples 2014–2016. Organized (resulting from an invitation) constituted 69% samples. The test coverage resident women aged 23–60 was...
Clinical trials in the research setting have demonstrated that primary human papillomavirus (HPV)-based screening results greater protection against cervical cancer compared with cytology, but evidence from real-life implementation was missing. To evaluate effectiveness of HPV-based within a program, organized, population-based program capital region Sweden offered either HPV- or cytology-based randomized manner through healthcare policy (RHP).A total 395,725 women aged 30 to 64 years were...
Human papillomavirus (HPV)-based cervical screening is a globally recommended health policy. Different HPV types have different risk for cancer. For optimal screening, the sensitivity and specificity each type at viral loads should be known in setting. test results about 1 million samples analyzed during 2006 to 2014 were compared 319 women who had developed invasive cancer up 8.5 years later 1911 matched control women. Detection including low resulted markedly increased only 16 18. Testing...
Human papillomavirus (HPV) vaccines protect against infections with the most oncogenic HPV types, cervical intraepithelial neoplasia (CIN) and cancer. We investigated whether development of lesions in HPV-vaccinated women is associated vaccine-targeted types or not. Linkage Swedish vaccination screening registries identified all females born 1980-2000 who had been vaccinated before December 31, 2014 (n = 305,320) attended 2006-2018 79,491). further selected below 17 years age screened...
Human papillomavirus-vaccinated cohorts, irrespective of age, will likely reduce their subsequent screening requirements, thus opening opportunities for global cost reduction and program sustainability. The determinants uptake completion a 3-dose human papillomavirus vaccination by adult women in European context were estimated.
Merkel cell carcinoma (MCC) is a rare type of skin cancer that has characteristically increased incidence among immunosuppressed subjects. The DNA polyomavirus (MCV) regularly found in most MCC tumors. We investigated whether infection increases the risk for future MCC. Two large biobank cohorts (Southern Sweden Microbiology Biobank and Janus Biobank), containing samples from 856,000 healthy donors, were linked to Cancer Registries Norway identify cases occurring up 30 years after donation...
The globally recommended public health policy for cervical screening is primary human papillomavirus (HPV) with cytology triaging of positives. To ensure optimal quality laboratory services we have conducted regular audits smears taken before cancer or in situ (CIN3+) within an HPV-based program. central Stockholm, Sweden, identified cases CIN3+ who had a previous test up to 3 years and randomly selected 300 liquid-based (LBC) samples auditing. HPV testing Roche Cobas was performed either at...
Studies investigating presence of viruses in cancer often analyze case series cancers, resulting detection many that are not etiologically linked to the tumors where they found. The incidence virus-associated cancers is greatly increased immunocompromised individuals. Non-melanoma skin (NMSC) also and a variety have been detected NMSC. As immunosuppressed patients develop multiple independent NMSCs, we reasoned consistently present might be more likely involved tumorigenesis. We sequenced 8...