Screening for cervical cancer based on testing human papillomavirus (HPV) increases the sensitivity of detection high-grade (grade 2 or 3) intraepithelial neoplasia, but whether this gain represents overdiagnosis protection against future epithelial neoplasia is unknown.

New colposcopy terminology was prepared by the Nomenclature Committee of International Federation Cervical Pathology and Colposcopy after a critical review previous terminologies, online discussions, discussion with national societies individual colposcopists. This document has been expanded to include both cervix vagina. The popular terms "satisfactory colposcopy" "unsatisfactory have replaced. colposcopic examination should be assessed for three variables: 1) adequate or inadequate, reason...

The effectiveness of cervical cancer screening programs differs widely in different populations. reasons for these differences are unclear. Routine and comprehensive audits have been proposed as an ethically required component screening. We performed a nationwide audit the Swedish program. identified all invasive cases that were diagnosed Sweden from January 1, 1999, through December 31, 2001, had reported to Cancer Registry (n = 1230 cases). verified diagnoses by histopathologic rereview...

BackgroundPrimary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cells a Pap test (cytology) has been evaluated in randomized clinical trials. Because the vast majority women positive cytology are also HPV positive, strategies that use as primary may be more effective.

<b>Objective</b> To determine whether detection of invasive cervical cancer by screening results in better prognosis or merely increases the lead time until death. <b>Design</b> Nationwide population based cohort study. <b>Setting</b> Sweden. <b>Participants</b> All 1230 women with diagnosed during 1999-2001 Sweden prospectively followed up for an average 8.5 years. <b>Main outcome measures</b> Cure proportions and five year relative survival ratios, stratified history, mode detection, age,...

To study the long term risk of invasive cancer cervix or vagina after treatment for cervical intraepithelial neoplasia grade 3.Prospective cohort study.Swedish registry.All women in Sweden with severe dysplasia carcinoma situ (equivalent to 3) treated during 1958-2002 (n=132,493) contributing 2,315,724 woman years.Standardised incidence ratios Swedish general female population as reference, and relative risks multivariable log-linear regression model, internal references.Women previous 3 had...

Screening for cervical cancer by testing human papillomavirus (HPV), the major cause of disease, reportedly increases sensitivity detecting high-grade (grade 2 or 3) intraepithelial neoplasia (CIN). It is not clear, however, whether this reflects protection against future CIN cancer, it represents over-diagnosis. This Swedish population-based screening program randomly assigned 12,527 women ranging in age from 32 to 38 years have either an HPV test plus a Pap (n = 6257, intervention group)...

BACKGROUND. The objective of this study was to evaluate whether liquid-based cytology (LBC) can improve high-standard cervical cancer screening further. primary endpoint histopathologic high-grade lesions in current and subsequent rounds. secondary endpoints were cytologic diagnosis inadequate samples. METHODS. Women randomized smear taking by conventional Papanicolaou (Pap) or LBC according the time appointment. Eight thousand eight hundred ten Pap smears 4674 samples included. Evaluations...

RACOMIP is a population-based, randomized trial of the effectiveness and cost-effectiveness different interventions aimed at increasing participation in well-run cervical cancer screening program western Sweden. In this article, we report results from one intervention, offering non-attendees high-risk human papillomavirus (HPV) self-test. Comparison was made with standard invitation routine or plus telephone call. Women (8,800), aged 30-62, were randomly selected among women without...

<b>Objective</b> To determine factors influencing long term risks for acquiring or dying from invasive cervical vaginal cancer in women previously treated intraepithelial neoplasia grade 3 (CIN3). <b>Design</b> Population based cohort study conducted 1958-2008, followed up until 2009 the Swedish Cancer Registry and Cause of Death Register, linked to Register. Standardised incidence mortality ratios were calculated risk cancer, with general female population Sweden as reference. Relative...

Background Cervical screening programs are highly protective for cervical cancer, but only women attending procedure. Objective Identify socio-economic and demographic determinants non-attendance in screening. Methods Design: Population-based case-control study. Setting: Sweden. Population: Source population was all eligible Based on complete records, two groups of aged 30–60 were compared. The case group, non-attending women, (N = 314,302) had no smear registered 6–8 years. control group...

In Brief Objective: It has been suggested that the accuracy of colposcopy is less reliable than once presumed. The Reid colposcopic index most well-known scoring system designed to standardize assessment and assist in prediction histological diagnosis. Strander et al. have devised a new system, Swede score, which includes lesion size as variable. This evaluation aimed validate score within London teaching hospital unit. Methods: An was carried out women undergoing at Royal Free Hospital,...

Background Treatment of cervical intraepithelial neoplasia (CIN) is associated with an increased risk preterm delivery (PTD) although the exact pathomechanism not yet understood. Women untreated CIN also seem to have PTD. It unclear whether this attributable human papillomavirus (HPV) infection or other factors. We aimed investigate HPV shortly before during pregnancy, as well previous treatment for CIN, PTD and adverse obstetric neonatal outcomes. Methods findings This was a retrospective...

Abstract Introduction Most cervical cancer cases in Sweden are diagnosed among women who have failed to attend screening. The objective of this study was analyze the effectiveness offering vaginal HPV (human papillomavirus) self‐samples long‐term non‐attendees as a routine screening program, which had already been targets several interventions. Material and Methods Register data from organized program were used population‐based study. From January 2016 December 2019, 33 881 high‐risk (hr‐)...

Objective. To construct a simple scoring system for colposcopic examination that can facilitate education of colposcopists and increase the accuracy evaluation. Design. Prospective clinical study. Setting population. Two hundred ninety‐seven examinations women referred colposcopy in western Sweden. Methods. Five variables were scored: acetowhiteness, margins surface, vessels, lesion size, iodine staining. Each variable could be assigned one three ordered values. Multiple logistic regression...

Non-participation is the foremost screening-related risk factor for cervical cancer. We studied effectiveness and cost-effectiveness of an intervention to increase participation in context a well-run screening program. Telephone contact with non-attendees, offering appointment take smear, was compared control group population-based randomized trial western Sweden. Of 8,800 randomly selected women aged 30-62, without registered Pap smear two latest rounds, 4,000 were telephone arm, another...

The management of cervical intraepithelial neoplasia grade 2 is a clinical dilemma. Cervical 3 considered cancer precursor and always treated with excision. Most the 1 cases regress spontaneously, it internationally mostly monitored expectant management. Surgical treatment entails increased risk preterm birth in future pregnancies. women aged under 25 years quite well-studied; regression rate high low. above, whom occult higher, has been less studied.

Sensitivity and specificity of colposcopy vary greatly between studies efficacy in clinical seldom corresponds with effectiveness a real-life setting. It is unclear whether colposcopists' experience affects assessment; show divergent results. The study's objective was to investigate the accuracy colposcopies Swedish screening program, variability assessments degree routine setting.Cross-sectional register study. All colposcopic concomitant histopathological sample from women aged at least 18...

Comprehensive nationwide monitoring and evaluation of screening through registry-based review key indicators is necessary for programme optimization, especially as new tests strategies are introduced. We aimed to investigate report on the use these in Swedish programme.Organized population-based cervical targeting women aged 23-50 51-60 every three five years, respectively, regionally implemented Sweden. All cytological histopathological test results invitations exported National Cervical...

Background To enable incremental optimization of screening, regular reporting quality indicators is required. Aim report key and basic statistics about cervical screening in Sweden. Methods We collected individual level data on all cytologies, histopathologies, human papillomavirus tests invitations for Sweden during 2013–2016. Results There were over 2,278,000 samples 2014–2016. Organized (resulting from an invitation) constituted 69% samples. The test coverage resident women aged 23–60 was...

Background: Treatment of cervical intraepithelial neoplasia grade 3 (CIN 3) removes or destroys part the cervix and might subsequently influence pregnancy outcomes. Objective: To investigate outcomes in women diagnosed with CIN 3. Design: Population- sibling-matched cohort study. Setting: Sweden, 1973 to 2018. Participants: The general population comparison included 78 450 singletons born 784 500 matched who had no diagnosis; sibling 23 199 28 135 their sisters without a diagnosis....

Abstract Background Excisional treatment of cervical intraepithelial neoplasia (CIN) has been associated with increased risk preterm delivery (PTD), although the underlying mechanism is as yet unclear. Studies on formalin-fixed excised tissue indicate that increases cone-length, but magnitude increase uncertain, especially in case minor excisions (≤10 mm), well compared to women untreated CIN during pregnancy. This study assesses impact cone-length at previous for diagnosis pregnancy PTD....

An increase in cervical cancer incidence Sweden from 2014 to 2015 has been attributed an false-negative cytological findings before diagnoses. Years later, we performed a long-term follow-up investigate whether the problem persisted. At each calendar year 2016 2020, identified women with prior normal screening results through linkage Swedish National Cervical Screening Registry. We reported their rates (IRs) of invasive consecutive years and compared IRs over time. For there was no overall...