A5037331723- Glioma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Advancements in Solid Oxide Fuel Cells
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Fuel Cells and Related Materials
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Electrocatalysts for Energy Conversion
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Intracranial Aneurysms: Treatment and Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Biomarkers in Disease Mechanisms
- Kruppel-like factors research
Tianjin Medical University General Hospital
2022-2025
First Affiliated Hospital Zhejiang University
2024-2025
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Third Affiliated Hospital of Zhengzhou University
2022-2025
Tianjin Medical University
2025
Science for Life Laboratory
2014-2024
Uppsala University
2014-2024
Ningbo First Hospital
2024
Ningbo University
2024
Cancer produces a variety of collateral effects in patients beyond the malignancy itself, including threats to distal organ functions. However, basis for such effects, associated with either primary or metastatic tumors, are generally poorly understood. In this study, we show how heart and kidney vascular function is impaired by neutrophils that accumulate those tissues as result tumor formation two different transgenic mouse models cancer (RIP1-Tag2 model insulinoma MMTV-PyMT breast...
Passage of systemically delivered pharmacological agents into the brain is largely blocked by blood-brain-barrier (BBB), an organotypic specialization endothelial cells (ECs). Tumor vessels in glioblastoma (GBM), most common malignant tumor humans, are abnormally permeable, but this phenotype heterogeneous and may differ between tumor's center invasive front. Here, through single-cell RNA sequencing (scRNA-seq) freshly isolated ECs from human paired peripheral tissues, we have constructed a...
Abstract Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) in clinical development for solid tumors, but yet to be evaluated glioma. Here, we demonstrate that systemic delivery of αCD40 preclinical glioma models induces the formation tertiary lymphoid structures (TLS) proximity meningeal tissue. In treatment-naïve patients, presence TLS correlates with increased T cell infiltration. However, hypofunctional...
Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) signaling pathway is in clinical use, but its effect on function and tumor microenvironment poorly understood. Here, we investigate cross-talk between VEGF proinflammatory TNF-α cells impact leukocyte recruitment. We found that cotreatment with decreased TNF-α-induced Jurkat cell adhesion to human microvascular by 40%. This was associated inhibition of TNF-α-mediated regulation 86 genes, including 2...
Abstract Glioblastoma are aggressive astrocytic brain tumours characterized by microvascular proliferation and an abnormal vasculature, giving rise to oedema increased patient morbidity. Here, we have the transcriptome of tumour‐associated blood vessels describe a gene signature clearly associated with pleomorphic, pathologically altered in human glioblastoma (grade IV glioma). We identified 95 genes differentially expressed vessels, while no significant differences expression were detected...
Abstract Background Systemic delivery of anti-tumor therapeutic agents to brain tumors is thwarted by the blood-brain barrier (BBB), an organotypic specialization endothelial cells (ECs). A failure pharmacological compounds cross BBB one culprit for dismal prognosis glioblastoma (GBM) patients. Identification novel vascular targets overcome challenges posed in GBM treatment urgently needed. Methods Temozolomide (TMZ) was investigated CT2A and PDGFB-driven RCAS/tv-a orthotopic glioma models....
Glioblastoma is an aggressive brain tumor characterized by abnormal blood vasculature that hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis this setting modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated vascular expression was correlated with poor survival clinical cohort patients high-grade astrocytic glioma. Similarly, intracranial growth the GL261 mouse model glioma delayed significantly CD93(-/-)...
Immune response mediated by macrophages is critical in tumor progression and implicates new targets potential efficient immunotherapies.Tumor associated (TAM) are divided into either polarized M1 or M2 phenotype depending on different regulators of polarization pro-or anti-oncogenic roles they play.Glioma-infiltrated TAMs have been newly reported contrary to the current dogma.Instead, glioma exhibit a continuum between M1-and M2-like TAM that resembling M0 macrophage.Here we proposed an OS...
Abstract The implantation of neural stem cells (NSCs) in artificial scaffolds for peripheral nerve injuries draws much attention. NSCs were ex-vivo expanded hyaluronic acid (HA)-collagen composite with neurotrophin-3, and BrdU-labeled conduit was implanted onto the ends transected facial rabbits. Electromyography demonstrated a progressive decrease current threshold increase voltage amplitude de-innervated rabbits after one, four, eight 12 weeks compared to readouts derived from animals...
Summary Aims The objective of this study was to analyze the efficacy polypyrrole/polylactic acid (PPy/PLA) nanofibrous scaffold cotransplanted with bone marrow stromal cells (BMSCs) in promoting functional recovery a rat spinal cord injury (SCI). Methods Female Sprague‐Dawley rats were randomly divided into three groups (n = 18/group): control group, PPy/PLA and PPy/PLA/BMSCs group. SCI induced all rats. Consequently, group transplanted 1 × 10 5 BMSCs after implantation PPy/PLA, while those...
Salmonella enterica remains one of the leading causes foodborne bacterial disease. Retail meat is a major source human salmonellosis. However, comparative genomic analyses S. isolates from retail different sources in China are lacking. A total 341 strains were isolated sixteen districts Beijing, China, at three time points (January 1st, May and October 1st) 2017. Comparative genomics was performed to investigate genetic diversity, virulence antimicrobial resistance gene (ARG) profiles these...
Acute myeloid leukemia is a malignant hematologic disorder characterized by the excessive proliferation and accumulation of immature cells. This abnormality disrupts normal hematopoiesis, leading to symptoms such as anemia, increased susceptibility infections bleeding. ADP-ribosylation factors (ARFs) are critical in various cellular functions, including vesicular trafficking, membrane dynamics, cytoskeleton organization, signal transduction, endocytosis, exocytosis, maintaining organelle...
Abstract The use of Santulli enterostomy (SE) for necrotizing enterocolitis (NEC) has been limited to a small number studies involving patients and no control group. Our study aimed compare the clinical safety efficacy with those single- or double-lumen neonatal NEC through retrospective cohort study. One hundred ten who met criteria were divided into an SE group (64 patients) conventional (CE) (46 patients). CE underwent enterostomy. There significant differences in complication rates...
ABSTRACT SKA3, an important factor in cell cycle regulation, is involved spindle assembly and kinetochore function, playing a critical role maintaining cancer proliferation division. However, its specific roles regulatory mechanisms remain not fully understood. Large‐scale datasets from multiple public databases, including The Cancer Genome Atlas Genotype‐Tissue Expression, covering various types, were integrated. Systematic analysis revealed that SKA3 exhibits aberrant expression patterns...
// Luuk van Hooren 1, * , Maria Georganaki Hua Huang 1 Sara M. Mangsbo # Anna Dimberg Department of Immunology, Genetics and Pathology, Science for Life Laboratory, The Rudbeck Uppsala University, Uppsala, Sweden These first authors contributed equally to the work have Correspondence to: Dimberg, email: anna.dimberg@igp.uu.se Keywords: CD40, sunitinib, MDSC, endothelial activation, T-cell Received: November 11, 2015 Accepted: June 12, 2016 Published: July ABSTRACT CD40-activating...
CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate recruitment during immune response, but the effect of on tumor endothelial has not been evaluated. Here, we have investigated how transcriptionally respond to isolating from agonistic CD40 mAb- or isotype-treated mice bearing B16-F10 melanoma, performing RNA-sequencing. Gene set enrichment analysis revealed that mAb therapy increased...
Abstract Background Clinical outcomes of patients with glioma are still poor, even after standard treatments, including surgery combined radiotherapy and chemotherapy. New therapeutic strategies targets for urgently needed. Plasminogen activator urokinase receptor (PLAUR), a highly glycosylated integral membrane protein, is reported to modulate plasminogen activation extracellular matrix degradation in many malignant cancers, but its role gliomas remains unclear. Methods Glioma samples mRNA...
Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms. In this study, we describe the inflammatory profile in CCM and show for first time formation of neutrophil extracellular traps (NETs) rodents humans CCM. Through RNA-seq analysis cerebellum endothelial cells from wild-type mice an cell-specific ablation Ccm3 gene (Ccm3iECKO), that Ccm3iECKO have increased expression inflammation-related genes. These genes encode proinflammatory cytokines...
A microchanneled asymmetric dual phase composite membrane of 70 vol % Gd(0.1)Ce(0.9)O(1.95-δ)-30 La(0.6)Sr(0.4)FeO(3-δ) (CGO-LSF) was fabricated by a "one step" phase-inversion tape casting. The sample consists thin dense (100 μm) and porous substrate including "finger-like" microchannels. oxygen permeation flux through the with without catalytic surface layers investigated under variety partial pressure gradients. At 900 °C, bare 1.6 (STP) ml cm(-2) min(-1) for air/He-case 10.10...
Aldehyde dehydrogenases (ALDH) is a family of enzymes including 19 members. For now, ALDH activity had been wildly used as marker cancer stem cells (CSCs). But biological functions relevant isoforms and their clinical applications are still controversial. Here, we investigate the significance potential function ALDH1A3 in gliomas. By whole-genome transcriptome microarray mRNA sequencing analysis, compared expression high- low- grade gliomas well different molecular subtypes. Microarray...
Central nervous system (CNS) blood vessels contain a functional blood-brain barrier (BBB) that is necessary for neuronal survival and activity. Although Wnt/β-catenin signaling essential BBB development, its downstream targets within the neurovasculature remain poorly understood. To identify of underlying maturation, we performed microarray analysis identified Fgfbp1 as novel Wnt/β-catenin-regulated gene in mouse brain endothelial cells (mBECs). expressed CNS endothelium secreted into...