A5085827973- Immune cells in cancer
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
University of Manchester
2018-2021
Science for Life Laboratory
2020
Uppsala University
2019-2020
Novo Nordisk (Denmark)
2019
Alligator Bioscience (Sweden)
2019
Life & Brain (Germany)
2019
Centre for Inflammation Research
2018
Natural Killer (NK) cells can engage multiple virally infected or tumor sequentially and deliver perforin for cytolytic killing of these targets. Using microscopy to visualize degranulation from individual NK cells, we found that repeated activation via the Fc receptor CD16 decreased amount secreted. However, secretion was restored upon subsequent a different activating receptor, NKG2D. Repeated stimulation NKG2D also secretion, but this not rescued by CD16. These outcomes sequential could...
CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate recruitment during immune response, but the effect of on tumor endothelial has not been evaluated. Here, we have investigated how transcriptionally respond to isolating from agonistic CD40 mAb- or isotype-treated mice bearing B16-F10 melanoma, performing RNA-sequencing. Gene set enrichment analysis revealed that mAb therapy increased...
One mechanism by which monoclonal antibodies (mAb) help treat cancer or autoimmune disease is through triggering antibody-dependent cellular cytotoxicity (ADCC) via CD16 on Natural Killer (NK) cells. Afucosylation known to increase the affinity of mAbs for NK cells and here, we set out assess how mAb afucosylation affects dynamics cell interactions, receptor expression effector functions. An IgG1 version a clinically important anti-CD20 was compared its afucosylated counterpart...
Abstract CD40, a tumor necrosis factor receptor superfamily member, is promising immune-boosting target in cancer immunotherapy due to its role promoting antitumor responses of immune cells. CD40 also expressed on endothelial cells but the response tumor-associated vasculature CD40-stimulating has not been studied. Herein, we have performed RNA-sequencing analysis murine (TECs) isolated from B16.F10 melanoma and MB49 bladder treated with agonistic monoclonal antibody (mAb) or isotype...