A5014234836- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Quantum Chromodynamics and Particle Interactions
- Microbial Inactivation Methods
- Advanced Neuroimaging Techniques and Applications
- Nuclear physics research studies
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound and Hyperthermia Applications
- Microfluidic and Bio-sensing Technologies
- High-Energy Particle Collisions Research
- Toxin Mechanisms and Immunotoxins
- Particle physics theoretical and experimental studies
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Nuclear Physics and Applications
- Traumatic Ocular and Foreign Body Injuries
- Lanthanide and Transition Metal Complexes
- Neurological disorders and treatments
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Advanced NMR Techniques and Applications
- Signaling Pathways in Disease
- Electrospun Nanofibers in Biomedical Applications
- Brain Metastases and Treatment
Sheba Medical Center
2015-2024
Tel Aviv University
2015-2024
InSightec (Israel)
2007
Tel Aviv Sourasky Medical Center
2006
Brigham and Women's Hospital
2003-2006
Harvard University
2006
Magen David Adom
2006
Cancer Research Center
2005
Vassar College
1994
Brookhaven National Laboratory
1992-1994
Background— Cell labeling with superparamagnetic iron oxide (SPIO) nanoparticles enables noninvasive MRI and tracking of transplanted stem cells. We sought to determine whether mesenchymal cell (MSC) outcome is affected by SPIO in a rat model myocardial infarction. Methods Results— Rat MSCs were labeled (ferumoxides; Endorem; Guerbet, Villepinte, France). By trypan-blue exclusion assay, almost 100% the cells remained viable after labeling. Seven days MI, rats randomized injections 2×10 6...
To study the feasibility of using diffusion-weighted magnetic resonance imaging (DWMRI), which is sensitive to diffusion water molecules in tissues, for detection early tumor response radiation therapy; and evaluate additional information obtained from high DWMRI, more low-mobility (such as intracellular or bound water), increasing sensitivity response.Standard MRI DWMRI were acquired before at regular intervals after initiating therapy 10 malignant brain lesions eight patients.One week...
OBJECTIVE Magnetic resonance imaging-guided high-intensity focused ultrasound (MRIgFUS) is a novel technique that may have the potential for precise image-guided thermocoagulation of intracranial lesions. The system delivers small volumetric sonications from an phased array transmitter focuses energy selectively to destroy target with verification by magnetic imaging-generated thermal maps. A Phase I clinical study was initiated treat patients recurrent glioma MRIgFUS. METHODS To date, three...
Abstract Background MDNA55 is an interleukin 4 receptor (IL4R)-targeting toxin in development for recurrent GBM, a universally fatal disease. IL4R overexpressed GBM as well cells of the tumor microenvironment. High expression associated with poor clinical outcomes. Methods MDNA55-05 open-label, single-arm phase IIb study (rGBM) patients aggressive form (de novo IDH wild-type, and nonresectable at recurrence) on their 1st or 2nd recurrence. was administered intratumorally single dose...
Diffusion-weighted magnetic resonance imaging (DWMRI) is sensitive to tissues' biophysical characteristics, including apparent diffusion coefficients (ADCs) and volume fractions of water in different populations. In this work, we evaluate the clinical efficacy DWMRI high diffusion-weighted (HDWMRI), acquired up b = 4000 sec/mm2 amplify sensitivity properties, pretreatment prediction brain tumors' response radiotherapy. Twelve patients with 20 lesions were studied. Six ring-enhancing excluded...
PURPOSE: To evaluate the use of diffusion-weighted magnetic resonance (MR) imaging with standard and high b values for pretreatment prediction early detection tumor response to various antineoplastic therapies in an animal model. MATERIALS AND METHODS: Mice bearing C26 colon carcinoma tumors were treated doxorubicin (n = 25) aminolevulinic acid–based photodynamic therapy 23). Fourteen mice served as controls. Conventional T2-weighted fast spin-echo MR images acquired once before at 6, 24, 48...
Background— Activated macrophages have a significant role in wound healing and damaged tissue repair. We sought to explore the ability of ex vivo activated promote repair infarcted myocardium. Methods Results— Human macrophage suspension (AMS) was prepared from whole blood unit obtained young donors closed sterile system by novel method hypo-osmotic shock. The AMS (&4×10 5 cells) included up 43% CD14-positive cells injected into ischemic myocardium rats (n=8) immediately after coronary...
Electroporation, is known to induce cell membrane permeabilization in the reversible (RE) mode and death irreversible (IRE) mode. Using an experimental system designed produce a continuum of IRE followed by RE around single electrode we used MRI study effects electroporation on brain. Fifty-four rats were injected with Gd-DOTA treated G25 implanted 5.5 mm deep into striata. was acquired immediately after treatment, 10 min, 20 30 up three weeks following treatment using: T1W, T2W, Gradient...
Conventional magnetic resonance imaging (MRI) is unable to differentiate tumor/nontumor enhancing tissues. We have applied delayed-contrast MRI for calculating high resolution treatment response assessment maps (TRAMs) clearly differentiating tissues in brain tumor patients. One hundred and fifty patients with primary/metastatic tumors were recruited scanned by perfusion MRI. Of those, 47 underwent resection during their participation the study. Region of interest/threshold analysis was...
High BMI, which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. This study examined of abdominal depots brain volumes whether sex modifies this association.
Abstract Convection-enhanced drug delivery (CED) is a novel approach to directly deliver drugs into brain tissue and tumors. It based on delivering continuous infusion of via intracranial catheters, enabling convective distribution high concentrations over large volumes the target while avoiding systemic toxicity. Efficient formation convection depends various physical physiologic variables. Previous convection-based clinical trials showed significant diversity in extent among patients...
Abstract Cancer cells of different solid and hematopoietic tumors express growth factors in respective stages tumor progression, which by autocrine paracrine effects enable them to grow autonomously. Here we show that the murine B16 melanoma cell line two human primary cultures stomach adenocarcinoma glioblastoma multiforme (GBM) constitutively secrete interleukin (IL)-10 an autocrine/paracrine manner. This cytokine is essential for proliferation because its neutralization decreases...
The blood-brain barrier (BBB) is limiting transcellular and paracellular movement of molecules cells, controls molecular traffic, keeps out toxins. However, this protective function the major hurdle for treating brain diseases such as tumors, Parkinson's disease, Alzheimer's etc. It was previously demonstrated that high pulsed electrical fields (PEFs) can disrupt BBB by inducing electroporation (EP) which increases permeability route. Our goal to study effects low PEFs, well below threshold...
<h2>Abstract</h2><h3>Introduction</h3> : Intracerebral radiation-induced contrast enhancement (RICE) can occur after photon as well proton beam therapy (PBT). This study evaluated the incidence, characteristics and risk factors of RICE PBT delivered to, or in direct proximity brain its impact on health-related quality life (HRQoL). <h3>Material Method</h3> Four hundred twenty-one patients treated by pencil beam-scanning between 2017 2021 were included. Follow-up included clinical evaluation...
Abstract Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There evidence for impaired blood–brain barrier (BBB) in both diseases, but its role the interplay between them not clear. Here, we investigated effects high‐fat diet (HFD), a model T2D, on Tg2576 mouse AD, regard to BBB function. We showed that HFD mice had higher weight, more insulin resistance, and serum HDL cholesterol levels, primarily mice, which also brain lipids content. In terms behavior,...
Abstract Background Electroporation-based therapies such as electrochemotherapy (ECT) and irreversible electroporation (IRE) are emerging promising tools for treatment of tumors. When applied to the brain, can also induce transient blood-brain-barrier (BBB) disruption in volumes extending beyond IRE, thus enabling efficient drug penetration. The main objective this study was develop a statistical model predicting cell death BBB induced by electroporation. This be used individual planning....
Retinal degeneration diseases affect millions of patients worldwide and lead to incurable vision loss. These are caused by pathologies in the retina underlying choroid, located back eye. One major challenges development treatments for these blinding is safe efficient delivery therapeutics into Previous studies demonstrated that narrow size distribution core-shell near infra-red fluorescent iron oxide (IO) nanoparticles (NPs) coated with human serum albumin (HSA, IO/HSA NPs) increase...
INTRODUCTION Magnetic resonance imaging (MRI)-guided focused ultrasound is a novel technique that was developed to enable precise, image-guided targeting and destruction of tumors by thermocoagulation. The system, ExAblate2000, delivery system embedded within the MRI bed conventional diagnostic scanner. device delivers small volumetric sonications from an phased array transmitter converge energy selectively destroy target. Temperature maps generated scanner verify location thermal rise as...