A5073711962- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Tryptophan and brain disorders
- Lanthanide and Transition Metal Complexes
- Neurofibromatosis and Schwannoma Cases
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Ocular Oncology and Treatments
- Boron Compounds in Chemistry
- MXene and MAX Phase Materials
- Solid State Laser Technologies
- Cancer, Stress, Anesthesia, and Immune Response
- Myasthenia Gravis and Thymoma
Paracelsus Medical University
2025
University of Salzburg
2025
MedAustron
2020-2024
Salzburger Landeskliniken
2024
Paul Scherrer Institute
2020
The Maria Sklodowska-Curie National Research Institute of Oncology
2014-2016
Medical University of Lublin
2009
<h2>Abstract</h2><h3>Introduction</h3> : Intracerebral radiation-induced contrast enhancement (RICE) can occur after photon as well proton beam therapy (PBT). This study evaluated the incidence, characteristics and risk factors of RICE PBT delivered to, or in direct proximity brain its impact on health-related quality life (HRQoL). <h3>Material Method</h3> Four hundred twenty-one patients treated by pencil beam-scanning between 2017 2021 were included. Follow-up included clinical evaluation...
Head and neck mucosal melanomas (HNMMs) are aggressive, radiotherapy-resistant cancers. Previous JCROS studies demonstrated improved local control with carbon-ion radiotherapy (CIRT). This study evaluates early outcomes of CIRT for HNMM using the European Japanese relative biological effectiveness (RBE)-adapted dose prescriptions. Between November 2019 April 2023, 14 patients received treatment. Postoperative R2 resection: 9 cases; biopsies only: 5 cases. Immune checkpoint inhibitors used as...
AIM:To investigate the correlations of pre-treatment positron emission tomography-computer tomography (PET-CT) metabolic quantifiers with clinical data unstratified gastric cancer (GC) patients. METHODS:Forty PET-CT scans utilising 18-fluorodeoxyglucose in patients who received no prior treatment were analysed.Analysis involved measurements maximum and mean standardised uptake volumes (SUV), coefficient variation (COV), tumour total lesion glycolysis different thresholds above which tumor...
The aim of this study was to evaluate the outcome patients with head and neck adenoid cystic carcinoma (ACC) treated using pencil beam scanning proton therapy (PBS PT) at our institution. Thirty-five who underwent treatment PBS PT for ACC between 2001 2017 were included. Local control (LC), distant (DC), progression-free survival (PFS), overall (OS) their prognostic factors evaluated. Adverse effects prospectively assessed. median patient follow-up 30 months. Prior PT, 26 (74.3%) surgery...
We analyzed the prognostic significance of indoleamine-2,3-dioxygenase (IDO) and type 1 receptors for transforming growth factor beta (TGF-βR1) interferon gamma (IFN-γR1) in resected nodal metastases 48 malignant melanoma patients. In 32 cases corresponding skin tumors were available. used immunohistochemical (IHC) staining which was assessed by pathologists a computer-aided algorithm that yielded quantitative results, both absolute relative. correlated results with patient outcome....
Grade I meningioma is the most common intracranial tumor in adults. The standard imaging for its radiation treatment planning MRI, and [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated PET/CT can further improve delineation. We investigated impact of on interobserver variability identifying 30 anonymized patients. Four oncologists independently contoured residual volume, first using only MRI subsequently with addition PET/CT. Conformity indices (CIs) were...
Skull base chordomas are radio-resistant tumors that require high-dose, high-precision radiotherapy, as can be delivered by particle therapy (protons and carbon ions). We performed a first clinical outcome analysis of based on the initial 4-years operation.Between August 2017 October 2021, 44 patients were treated with proton (89%) or ion (11%). Prior gross total resection had been in 21% lesions, subtotal 57%, biopsy 12% decompression 10%. The average prescription dose was 75.2 Gy RBE 37...
The overexpression of somatostatin receptor type 2 (SSTR2) is a property various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET 5 SBPGL. Four independent observers were instructed to contour macroscopic volume planning MRI then reassess their volumes with additional...
Brain metastases (BM) in non-small-cell lung cancer (NSCLC) patients present an increasing clinical challenge. Identifying biomarkers which specifically identify at high risk of BM may improve their early diagnosis, is crucial for surgical and radiotherapeutic treatment outcome. Alpha-2,6-sialyltransferase (α-2,6-ST) the primary product its activity, alpha-2,6-galactose-linked sialic acids (α-2,6-GalSA) have been found responsible adhesion tumor cells to brain vessels' endothelium enabling...
To evaluate the accuracy offluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (
Abstract Introduction: Indoleamine-2,3-dioxygense (IDO) is the enzyme that catalyzes first step of tryptophan catabolism pathway in humans. It known to impose a local immunosuppressive effect due hypersensitivity lymphocytes either depletion itself or accumulation metabolic intermediates its pathway. Transforming growth factor beta (TGF-β) and interferon gamma (IFN-γ) are well-recognized positive regulators IDO; both them up-regulate IDO1 gene expression. Physiologically, IDO prevents...