A5015140066- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Epilepsy research and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Adrenal and Paraganglionic Tumors
- Dementia and Cognitive Impairment Research
- Neurotransmitter Receptor Influence on Behavior
Medical University of Vienna
2016-2025
Donauspital
2024-2025
University of Vienna
1999-2022
Peking University
2022
Peking University Third Hospital
2022
Klinik und Poliklinik für Nuklearmedizin
2021
Seoul National University Hospital
2016
Innsbruck Medical University
2005-2015
Universität Innsbruck
2005-2015
Comprehensive Cancer Center Vienna
2013
The present procedural guidelines summarize the current views of EANM Neuro-Imaging Committee (NIC). purpose these is to assist nuclear medicine practitioners in making recommendations, performing, interpreting, and reporting results [18F]FDG-PET imaging brain. aim help achieve a high-quality standard [18F]FDG brain further increase diagnostic impact this technique neurological, neurosurgical, psychiatric practice. document replaces former version that have been published 2009. These new...
To provide practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor (SSTR) ligands. This joint standard was collaboratively developed by the European Association Nuclear Medicine (EANM), Society Molecular Imaging (SNMMI), Neurooncology (EANO), PET task force Response Assessment in Working Group (PET/RANO). Positron emission tomography (PET) ligands can detect meningioma tissue with high sensitivity specificity...
Intraoperative identification of anaplastic foci in diffusely infiltrating gliomas (DIG) with non-significant contrast-enhancement on MRI is indispensible to avoid histopathological undergrading and subsequent treatment failure. Recently, we found that 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence can visualize areas increased proliferative metabolic activity such intraoperatively. As DIG predominantely based World Health Organisation (WHO) parameters, analyzed...
Abstract Dopamine transporter imaging is widely used for the differential diagnosis of parkinsonism. Only limited data are available on relationship between striatal dopamine binding and dopaminergic cell loss in substantia nigra (SN). We analyzed postmortem SN counts patients who had previously undergone single‐photon emission computed tomography (SPECT). Pathological diagnoses included Parkinson's disease (n = 1), dementia with Lewy bodies 2), multiple system atrophy corticobasal...
Gliomas are the most common type of tumor in brain. Although definite diagnosis is routinely made ex vivo by histopathologic and molecular examination, diagnostic work-up patients with suspected glioma mainly done using MRI. Nevertheless, l-S-methyl-11C-methionine (11C-MET) PET holds great potential characterization gliomas. The aim this study was to establish machine-learning-driven survival models for built on 11C-MET characteristics, patient characteristics. Methods: included 70 a...
Abstract Epilepsy is one of the most frequent neurological conditions with an estimated prevalence more than 50 million people worldwide and annual incidence two million. Although pharmacotherapy anti-seizure medication (ASM) treatment choice, ~30% patients epilepsy do not respond to ASM become drug resistant. Focal form epilepsy. In drug-resistant focal epilepsy, surgery a option depending on localisation seizure focus for relief or freedom consecutive improvement in quality life. Beside...
Positron emission tomography (PET) has been widely used in paediatric oncology. 2-Deoxy-2-[
The nervous and circulatory system interconnects the various organs of human body, building hierarchically organized subsystems, enabling fine-tuned, metabolically expensive brain-body inter-organ crosstalk to appropriately adapt internal external demands. A deviation or failure in function a single organ subsystem could trigger unforeseen biases dysfunctions entire network, leading maladaptive physiological psychological responses. Therefore, quantifying these networks healthy individuals...
Summary Purpose The current concept for hemispherotomy includes various lateral techniques and the vertical perithalamic introduced by Delalande in 1992. We have chosen approach because of advantages that possibly influence outcome: possibility to completely disconnect hemisphere at level thalamus obviating both need resect insula open dissect subarachnoid space Sylvian fissure. Methods retrospectively analyzed prospectively collected data all patients who underwent Vienna pediatric epilepsy...
Selective serotonin reuptake inhibitors (SSRIs) modulate serotonergic neurotransmission by blocking of from the extracellular space. Up to now, it has been unclear how SSRIs achieve their antidepressant effect. However, task-based and resting state functional MRI studies, have demonstrated connectivity changes between brain regions. Here, we use positron emission tomography (PET) quantify SSRI's main target, transporter (SERT), assess treatment-induced molecular in interregional relation...
Absolute quantification of PET brain imaging requires the measurement an arterial input function (AIF), typically obtained invasively via cannulation. We present approach to automatically calculate image-derived (IDIF) and cerebral metabolic rates glucose (CMRGlc) from [18F]FDG data using integrated PET/MRI system. Ten healthy controls underwent test–retest dynamic [18F]FDG-PET/MRI examinations. The protocol consisted a 60-min list-mode acquisition together with time-of-flight MR angiography...
Abstract Purpose There is evidence that mild cognitive impairment (MCI) or Alzheimer's disease (AD) accompanied by alterations in the retina. The current study was performed to investigate structural and functional changes patients with systemic neurodegenerative disease. Methods A total of 47 either MCI AD 43 healthy age‐ sex‐matched control subjects were included. Inclusion criteria for abnormal memory function a mini‐mental state examination (MMSE) score >26 points, diagnosis probable...
Positron emission tomography (PET) provides precise molecular information on physiological processes, but its low temporal resolution is a major obstacle. Consequently, we characterized the metabolic response of human brain to working memory performance using an optimized functional PET (fPET) framework at 3 s.
Abstract Purpose Functional PET (fPET) is a novel technique for studying dynamic changes in brain metabolism and neurotransmitter signaling. Accurate quantification of fPET relies on measuring the arterial input function (AIF), traditionally achieved through invasive blood sampling. While non-invasive image-derived functions (IDIF) offer an alternative, they suffer from limited spatial resolution field view. To overcome these issues, we developed validated scan protocol utilizing cardiac...
Long acting somatostatin-14 (SST) analogs are used clinically to inhibit tumor growth and proliferation of various types via binding specific receptors (R). We have developed a 111In-/90Y-labeled SST analog, DOTA-(d)βNal1-lanreotide (DOTALAN), for diagnosis therapy. 111In-/90Y-DOTALAN bound with high affinity (dissociation constant, Kd, 1–12 nm) number primary human tumors (n = 31) such as intestinal adenocarcinoma 17; 150-4000 fmol/mg protein) or breast cancer 4; 250-9000 protein)....
Outcomes following functional hemispherotomy in patients with drug-resistant epilepsy have been well described. However, studies reporting long-term longitudinal outcomes after subhemispheric disconnective surgery are still limited.The authors conducted a retrospective review of prospectively collected data 10 children who underwent temporoparietooccipital (TPO) at the Vienna Pediatric Epilepsy Center.There were 3 males and 7 females (median age 8.7 years; range 4.2-22.1 years). The affected...
Attention-deficit/hyperactivity disorder (ADHD) research has long focused on the dopaminergic system's contribution to pathogenesis, although results have been inconclusive. However, a case made for involvement of noradrenergic system, which modulates cognitive processes, such as arousal, working memory, and response inhibition, all are typically affected in ADHD. Furthermore, norepinephrine transporter (NET) is an important target frequently prescribed medication Therefore, NET suggested...