A5009110604- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Birth, Development, and Health
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Postharvest Quality and Shelf Life Management
- Plant Physiology and Cultivation Studies
- Plant Surface Properties and Treatments
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Antioxidant Activity and Oxidative Stress
- Lipid metabolism and biosynthesis
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects of Natural Compounds
- Eicosanoids and Hypertension Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet and metabolism studies
- Caveolin-1 and cellular processes
- Lipid Membrane Structure and Behavior
- Photosynthetic Processes and Mechanisms
- Ginseng Biological Effects and Applications
- Alcohol Consumption and Health Effects
Tel Aviv University
2014-2023
Sheba Medical Center
2013-2023
Alzheimer's Association of Israel
2018
Arthur M. Sackler Gallery
2015
Agricultural Research Organization
1997-1999
Changes in the degree of fatty acid (FA) desaturation are implicated plant responses to various abiotic stresses, including heat, salt and drought. However, it is still not known whether decreased levels linolenic acid, found many plants subjected drought stress, reflect a mechanism defence or damage. We addressed this question by generating tobacco cells ectopically overexpressing two FA desaturases: cytosolic FAD3 plastidic FAD8. A remarkable increase ratio total linoleic acids resulted...
Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) exert health benefits which are dependent upon their incorporation into blood, cells and tissues. Plasma tissue deposition of LC PUFA from oils extracted the micro-algae Nannochloropsis oculata krill were compared in rats. The algal oil provides eicosapentaenoic acid (EPA) partly conjugated (15%) to phospholipids glycolipids but no docosahexaenoic (DHA), whereas both EPA DHA part (40%) phospholipids. Rats fed a standard diet...
In females, hyperglycemia abolishes estrogen-vascular protection, leading to inflammation and oxidative stress that are related diabetes-associated cardiovascular complications. Such knowledge led us examine the potential of glabridin, as a replacement estrogen anti-inflammatory activity under high-glucose conditions.In macrophage-like cells, chronic glucose (28 44 mM) upregulated inducible nitric oxide synthase (iNOS) mRNA expression by 42 189%, respectively. Pretreatment with stress,...
Abstract Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There evidence for impaired blood–brain barrier (BBB) in both diseases, but its role the interplay between them not clear. Here, we investigated effects high‐fat diet (HFD), a model T2D, on Tg2576 mouse AD, regard to BBB function. We showed that HFD mice had higher weight, more insulin resistance, and serum HDL cholesterol levels, primarily mice, which also brain lipids content. In terms behavior,...
Cognitive decline, the primary clinical phenotype of Alzheimer's disease (AD), is currently attributed mainly to amyloid and tau protein deposits. However, a growing body evidence converging on brain lipids, blood-brain barrier (BBB) dysfunction, as crucial players involved in AD development. The critical role lipids metabolism its vascular barrier, constant modifications particularly throughout development, warrants investigation lipid high value therapeutic target. Yet, there limited...
Fatty acid bile conjugates (FABACs) are a new family of synthetic molecules designed to solubilize biliary cholesterol. They were shown prevent and dissolve cholesterol gallstones in inbred C57L/J mice fed lithogenic, high-fat diet (HFD). In these mice, fatty liver was observed the controls but not FABAC-treated ones. The present study effect FABAC (arachidyl-amido-cholanoic acid) on diet-induced rats, hamsters, mice. score (on scale 0-4 by light microscopy) 4.0 control hamsters 0.3...
Scope Hyperglycemia is associated with oxidative stress, which accelerates cardiovascular complications. This study investigates the potential of glabridin to regulate paraoxonase 2 (PON2) levels, in vivo, and explores protective effect on PON2 through tryptophan‐fluorescence quenching mass spectrometry. Methods results Adult mouse offspring saturated fatty acids fed mothers, developed hyperglycemia after exposure a high fat diet their adult life, had lower levels heart mRNA protein...
Alpha linolenic acid (ALA, 18:3) in maternal diets has been shown to attenuate obesity associated insulin resistance (IR) adult offspring mice. The objective the present study was detect early effects of dietary saturated fatty acids (SFA) and their partial substitution with ω-3 ALA, docosa hexenoic (DHA,22:6) eicosapentenoic 20:5 (EPA,20:5) on HOMA index, liver lipids desaturases at weaning. 3 month old C57Bl6/J female mice were fed containing normal amount calories but rich SFA alone or...
SUMMARY The preformed (Z,Z)-1-acetoxy-2-hydroxy-4-oxo-heneicosa-12,15-diene (AFD) is the most active antifungal compound in avocado; it affects quiescence of Colletotrichum gloeosporioides unripe fruit. One genes encoding Delta(12) fatty acid desaturase (avfad12) was hypothesized to take part biosynthesis AFD, and its expression pattern enzymatic activity were determined relation content AFD. Using avfad12-3 as a probe, high levels detected young fruits leaves, where level AFD highest. In...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic in industrialized countries. It has no accepted medical therapy. Fatty acid-bile acid conjugates (FABACs) were proven to prevent diet-induced NAFLD rodents.This study was undertaken test whether oral FABACs are also effective reducing fat preestablished NAFLD.NAFLD induced mice and rats by a high-fat diet maintained various proportions thereof. The used of cholic with either arachidic or stearic acids.FABAC therapy reduced...
Objective: Our objective was to test the contribution of dietary enrichment in essential or saturated fatty acids, normocaloric diets, on lipid accumulation and insulin resistance adult offspring a C57Bl6/J mice model. Methods: Pregnant mothers were fed diets containing 6% fat enriched acids (EFA): alpha-linolenic (ALA-18:3, n-3), linoleic (LA-18:2, n-6), (SFA). After washing-out period with regular diet, received high-fat diet before euthanization. Results: Adult maternal ALA showed lower...
Obesity promotes the biogenesis of adipose tissue (AT) foam cells (FC), which contribute to AT insulin resistance. Autophagy, an evolutionarily-conserved house-keeping process, was implicated in cellular lipid handling by either feeding and/or degrading lipid-droplets (LDs). We hypothesized that beyond phagocytosis dead adipocytes, AT-FC is supported microenvironment regulating autophagy. Non-polarized ("M0") RAW264.7 macrophages exposed conditioned media (AT-CM) exhibited a markedly...
The insulin-like growth factor (IGF) system plays a critical role in normal and development as well malignant states. Most of the biological activities IGFs are mediated by IGF-IR, which is over-expressed most tumours cancer cell lines. Fatty acids have roles both systemic physiological processes (e.g. metabolism) cellular events proliferation, apoptosis, signal transduction, gene expression). Alpha-linolenic acid (ALA) linoleic (LA) essential fatty omega-3 omega-6 families, respectively....
Streptozotocin (STZ)-induced diabetes in mice progresses with decreased desaturase activities and alterations the metabolism of essential fatty acids (EFA). Objectives: Based on our previous studies soybean oil that ameliorated STZ damage mice, we tested here accountability its main EFA components, i.e. linoleic acid (LA) alpha linolenic (ALA), prevention pancreas Δ6 decrease. Materials methods: Seven days after injection gavage, ICR were sacrificed. Plasma glucose insulin levels, histology...
We have recently synthesized fatty acid bile conjugates (FABAC) that were able to reduce and retard cholesterol crystallization in model human biles. When given orally, they prevented the formation of crystals hamsters. The aim present study was determine whether FABAC are solubilizers, can dissolve pre-existing crystals, prevent gallstones, investigate optimal type bond between acid. presence determined by light microscopy, total crystal mass precipitated measured chemical means. Inbred...
Preoperative chemotherapy for hepatic resection of colorectal liver metastases is associated with the development chemotherapy-associated steatohepatitis (CASH). This increases risk perioperative morbidity and mortality. To authors' knowledge, an animal model CASH has not been described previously. It established that fatty acid bile conjugates (FABACs) prevent formation diet-induced liver. The current study was designed to establish use effect FABACs on its occurrence.C57BL/6 mice were...
<b><i>Background/Aims:</i></b> Lipid metabolic disarray in the liver of young and adult mice offspring is induced by saturated fatty acids (SFA) but prevented α-linolenic acid (ALA, 18:3 &#x03C9;-3) maternal diet during pregnancy lactation. The aim present study was to analyze impact dietary ALA compared an SFA on gene expression newborn offspring. <b><i>Methods:</i></b> C57Bl6/J dams were fed with diets normal calories rich or before...
Gallstones, mostly cholesterol stones, affect some 15% of the population. Oral bile salts dissolve human gallstones, but with low efficacy, and surgery remains main therapeutic option. Fatty acid conjugates (FABACs) were shown to prevent formation gallstones in experimental animals. The aim this study was test whether these compounds could preexisting via oral administration. Inbred, gallstone-susceptible C57J/L mice given a lithogenic diet for 2 months, presence ascertained. then switched...