A5083837661- Gut microbiota and health
- Sleep and related disorders
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Coffee research and impacts
- Advanced Glycation End Products research
- Gestational Diabetes Research and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Food Allergy and Anaphylaxis Research
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Paraoxonase enzyme and polymorphisms
- Pharmacological Effects of Natural Compounds
- Hemoglobin structure and function
- Agriculture Sustainability and Environmental Impact
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Medicinal Plant Extracts Effects
- Eosinophilic Esophagitis
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Attention Deficit Hyperactivity Disorder
- Nutritional Studies and Diet
- Child and Adolescent Psychosocial and Emotional Development
- Animal and Plant Science Education
Tel Hai Academic College
2019-2024
Migal - Galilee Technology Center
2015-2024
Western Galilee Hospital
2015-2017
Bar-Ilan University
2014-2017
Objective Gestational diabetes mellitus (GDM) is a condition in which women without are diagnosed with glucose intolerance during pregnancy, typically the second or third trimester. Early diagnosis, along better understanding of its pathophysiology first trimester may be effective reducing incidence and associated short-term long-term morbidities. Design We comprehensively profiled gut microbiome, metabolome, inflammatory cytokines, nutrition clinical records 394 before GDM diagnosis. then...
Abstract Background Multiple studies suggest a key role for gut microbiota in IgE-mediated food allergy (FA) development, but to date, none has studied it the persistent state. Methods To characterize composition and short-chain fatty acid (SCFAs) profiles associated with major groups, we recruited 233 patients FA including milk ( N = 66), sesame 38), peanut 71), tree nuts 58), non-allergic controls 58). DNA was isolated from fecal samples, 16S rRNA gene sequences were analyzed. SCFAs stool...
Abstract Physical activity (PA) can improve functional abilities, well-being, and independence in older adults with insomnia. Studies have shown that PA may be linked to changes the gut microbiota composition its metabolites’ concentrations. This association among insomnia, however, is yet determined. We explored relationships between physical levels, composition, short-chain fatty acid (SCFA) levels this population. Forty-nine community-dwelling insomnia symptoms, aged 65 older,...
Insomnia is a disorder characterized by difficulty falling asleep and poor sleep continuity associated with increased risks for physical cognitive decline. short duration considered the most biologically severe phenotype of disorder. Evidence suggests that short-chain fatty acids (SCFAs), main byproducts fiber fermentation in gut, may affect via gut-brain communications. This study explores associations between SCFAs compares SCFA concentrations vs. normal insomnia phenotypes older adults....
Attention-Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder with complex genetic and environmental underpinnings. Emerging evidence suggests significant role of gut microbiota in ADHD pathophysiology. This study investigates variations composition Short-Chain Fatty Acid (SCFA) profiles between children adolescents healthy controls.
As part of the quest for sustainable food choices, edible insects draw increasing attention. Nevertheless, not enough is known regarding their digestive fate and specifically little on colonic fermentability or chitin, which found in many crustaceans. This study interrogated properties powders from crickets (Acheta domestica), silkworm pupae (Bombyx mori) isolated chitin. was done following vitro oral, gastric intestinal digestion subsequent fermentation anaerobic bioreactors inoculated with...
Recent evidence suggests that the gut microbiota plays a role in insomnia pathogenesis. This study compared dietary habits and metabolites of older adults with short vs. normal sleep duration (ISSD INSD, respectively). Data collection included assessment through actigraphy, analysis using Food Frequency Questionnaire, metabolomic profiling stool samples. The results show ISSD individuals had higher body mass index greater prevalence hypertension. Significant differences were observed, group...
Hypoalbuminemia of Hemodialysis (HD) patients is an independent cardiovascular risk factor, however, there no mechanistic explanation between hypoalbuminemia and vascular injury. In the event oxidative stress inflammation to which HD are exposed, albumin oxidized undetected by common laboratory methods, rendering apparent hypoalbuminemia. We wanted show that these circulating modified molecules cause direct damage, mediating inflammation. Once in-vivo modifications were reduced in- vitro,...
Scope Hyperglycemia is associated with oxidative stress, which accelerates cardiovascular complications. This study investigates the potential of glabridin to regulate paraoxonase 2 (PON2) levels, in vivo, and explores protective effect on PON2 through tryptophan‐fluorescence quenching mass spectrometry. Methods results Adult mouse offspring saturated fatty acids fed mothers, developed hyperglycemia after exposure a high fat diet their adult life, had lower levels heart mRNA protein...
Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. The mechanism underlying this comorbidity not fully understood. A growing literature suggests the importance gut microbiota for brain function. We tested associations between sleep quality and performance with in adults insomnia.Seventy-two insomnia (age 73.2 ± 5.73 years, 56 females) provided stool samples microbial sequencing. Microbiota profile was determined using DADA2 bioinformatics...
Introduction The impact of diet on mental well-being and gut microorganisms in humans is well recognized. However, research the connections between food nutrients, microbiota, health remains limited. To address this, present study aimed to assess effects a personalized diet, based individual needs aligned with Mediterranean principles, depression symptoms, quality life, nutritional intake, microbiota changes among older adults living community. Methods intervention involved regular visits...
Energy drink (ED) consumption among Israeli-Arab adolescents is widespread. This study aimed to investigate the acute glycemic and insulin effects of EDs in healthy adolescents. Seventy-one (56% girls, average age 16.04 ± 1.03 years) participated a non-randomized, case-controlled, open-label study. Participants consumed ED (n = 36) or volume- carbohydrate-matched non-caffeinated soft (SD, n 35), followed by 2 h glucose tolerance test. Blood was measured at baseline 15, 30, 60, 120 min...
Energy drink (ED) consumption among Israeli-Arab adolescents is widespread. This study aimed to investigate the acute glycemic and insulin effects of EDs in healthy adolescents. Seventy-one (56% girls, average age 16.04±1.03 years) participated a non-randomized, case-controlled, open-label study. Participants consumed ED (n=36) or volume- carbohydrate-matched non-caffeinated soft (SD, n=35), followed by 2 h glucose tolerance test. Blood was measured at baseline 15, 30, 60, 120...
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition often persisting into adulthood, characterized by inattention, impulsivity, and hyperactivity. Emerging research suggests connection between ADHD gut microbiota, highlighting probiotics as potential therapeutic agents. This study involved double-blind, randomized controlled trial where college students with received either multi-strain probiotic supplement or placebo daily for three months. symptoms were...
Abstract Gestational diabetes mellitus (GDM) is a condition in which non-diabetic women are diagnosed with glucose intolerance during pregnancy, typically the second trimester. GDM can lead to wide range of obstetrical and metabolic complications for both mother neonate 1 . Early identification risk, along better understanding its pathophysiology first trimester may be effective reducing incidence, as well associated short long term morbidities 2 Here, we comprehensively profiled gut...