A5047270400- Gut microbiota and health
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Salivary Gland Disorders and Functions
- Head and Neck Cancer Studies
- Clostridium difficile and Clostridium perfringens research
- Oral health in cancer treatment
- Gestational Diabetes Research and Management
- Mycobacterium research and diagnosis
- Phytochemicals and Antioxidant Activities
- Diabetes Management and Education
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal motility and disorders
- Tea Polyphenols and Effects
- Food composition and properties
- Birth, Development, and Health
- Sirtuins and Resveratrol in Medicine
- Neutropenia and Cancer Infections
- Essential Oils and Antimicrobial Activity
- Anesthesia and Neurotoxicity Research
- Phytochemistry and Biological Activities
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
Bar-Ilan University
2018-2024
Objective Gestational diabetes mellitus (GDM) is a condition in which women without are diagnosed with glucose intolerance during pregnancy, typically the second or third trimester. Early diagnosis, along better understanding of its pathophysiology first trimester may be effective reducing incidence and associated short-term long-term morbidities. Design We comprehensively profiled gut microbiome, metabolome, inflammatory cytokines, nutrition clinical records 394 before GDM diagnosis. then...
Abstract Oral mucositis (OM) is a common debilitating dose-limiting toxicity of cancer treatment, including hematopoietic stem cell transplantation (HSCT). We hypothesized that the oral microbiome disturbed during allogeneic HSCT, partially accounting for variability in OM severity. Using 16S ribosomal RNA gene sequence analysis, metabolomic profiling, and computational methods, we characterized behavior salivary metabolome 184 patients pre- post-HSCT. Transplantation was associated with...
The consumption of teff (Eragrostis tef), a gluten-free cereal grain, has increased due to its dense nutrient composition including complex carbohydrates, unsaturated fatty acids, trace minerals (especially Fe), and phytochemicals. This study utilized the clinically-validated Gallus gallus intra amniotic feeding model assess effects intra-amniotic administration extracts versus controls using seven groups: (1) non-injected; (2) 18Ω H2O injected; (3) 5% inulin; (4) extract 1%; (5) 2.5%; (6)...
Objectives To investigate the role of gut microbiota (GM) in pathogenesis idiopathic short stature (ISS) by comparing GM ISS children to their normal-height siblings. Methods This case-control study, conducted at Schneider Children’s Medical Center’s Institute for Endocrinology and Diabetes between 4/2018-11/2020, involved 30 pairs healthy pre-pubertal siblings aged 3-10 years, each comprising one sibling with normal height. Outcome measures from fecal analysis both included composition...
BMI and diabetes can affect the gut microbiome composition. Bariatric surgery has large variabilities in outcome.
This efficacy trial evaluated the effects of two polyphenolic stilbenes, resveratrol and pterostilbene, mostly found in grapes, on brush border membrane functionality, morphology gut microbiome. study applied validated Gallus gallus intra-amniotic approach to investigate stilbene administration versus controls. Three treatment groups (5% resveratrol; 5% pterostilbene; synergistic: 4.75% 0.25% pterostilbene) three controls (18 MΩ H2O; no injection; inulin) were employed. We observed...
Abstract We observed high rates of bloodstream infections (BSIs) following fecal microbiota transplantation (FMT) for graft-versus-host-disease (33 events in 22 patients). To trace the BSIs' origin, we applied a metagenomic bioinformatic pipeline screening donor and recipient stool samples bacteremia-causing strains 13 cases. Offending were not detected FMT donations. Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii could be before emerging blood. In...
Phenolic acids, in free soluble form and cell wall-bound, were extracted from leaves stems 40 genetic variants 25 populations of Mentha longifolia native to Israel. Rosmarinic caffeic acid the most abundant freely acids whereas was among wall-bound phenolic acids. Assessment total antioxidant efficacy, based on reduction 1,1-diphenyl-2-picryldrazyl (DPPH), revealed high activity by tissues many M. variants, stemming part, rosmarinic acid. Although extractable comprise a major portion found...
Background Oral mucositis (OM) is a debilitating multifactorial complication of hematopoietic stem cell transplantation (HSCT). We hypothesized that the oral microbiome disturbed during and may partially account for variability in OM severity across patients. Methods In this single-center study, we prospectively collected saliva samples weekly cohort 184 adults undergoing allogeneic HSCT. A total 625 were starting from 7 days before HSCT to 34 post-transplant. Samples underwent 16S rRNA gene...
Abstract Gestational diabetes mellitus (GDM) is a condition in which non-diabetic women are diagnosed with glucose intolerance during pregnancy, typically the second trimester. GDM can lead to wide range of obstetrical and metabolic complications for both mother neonate 1 . Early identification risk, along better understanding its pathophysiology first trimester may be effective reducing incidence, as well associated short long term morbidities 2 Here, we comprehensively profiled gut...
Abstract Background: Bariatric surgery is often the preferred method to resolve obesity and diabetes, with ~800,000 cases worldwide yearly high outcome variability. The ability predict long-term BMI change following has important implications on individuals health care system in general. Given tight connection between eating habits, sugar consumption, gut microbiome, we tested whether microbiome before any treatment associated different outcomes, as well other intakes (HDL, Triglycerides,...
Abstract Background Bariatric surgery is often the preferred method to resolve obesity and diabetes, with ~800,000 cases worldwide yearly high outcome variability. The ability predict long-term Body Mass Index (BMI) change following has important implications on individuals health care system in general. Given tight connection between eating habits, sugar consumption, BMI, gut microbiome, we tested whether microbiome before any treatment associated different outcomes, as well other intakes...