A5088169519- Fungal Biology and Applications
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Polysaccharides and Plant Cell Walls
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Ion Transport and Channel Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Infant Nutrition and Health
- Estrogen and related hormone effects
- Diet and metabolism studies
- Cell death mechanisms and regulation
- Nutritional Studies and Diet
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Cancer-related Molecular Pathways
- Probiotics and Fermented Foods
- Biochemical Analysis and Sensing Techniques
Hebrew University of Jerusalem
2016-2025
New York University Press
2010
Cambridge University Press
2010
The University of Texas MD Anderson Cancer Center
2007
National Cancer Institute
2006
Ben-Gurion University of the Negev
1980-1998
Soroka Medical Center
1982-1998
Objective Gestational diabetes mellitus (GDM) is a condition in which women without are diagnosed with glucose intolerance during pregnancy, typically the second or third trimester. Early diagnosis, along better understanding of its pathophysiology first trimester may be effective reducing incidence and associated short-term long-term morbidities. Design We comprehensively profiled gut microbiome, metabolome, inflammatory cytokines, nutrition clinical records 394 before GDM diagnosis. then...
Allicin (diallyl thiosulfinate) is the best-known biologically active component in freshly crushed garlic extract. We developed a novel, simple method to isolate allicin, which yielded stable compound aqueous solution amenable for use vitro and vivo studies. focused on effects of allicin cell proliferation colon cancer lines HCT-116, LS174T, HT-29, Caco-2 assessed underlying mechanisms. This preparation exerted time- dose-dependent cytostatic effect these cells at concentrations ranging from...
Genistein, like other phytochemicals, has beneficial health effects, but its bioavailability is limited. This research studied the effect of complexation genistein with starch on bioavailability. Genistein release from these complexes was tested in vitro under simulated intestinal conditions and vivo rats fed high-amylose corn (HACS)-genistein (experimental group) as compared to those a physical mixture HACS (controls). In results showed that sustained fits normal transit time food...
Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder leading to high morbidity and mortality rates. A growing body of evidence demonstrate the key role Toll like receptor 4 (TLR4) in NEC. This membranal recognizes lipopolysaccharides (LPS) from bacterial wall triggers an response. The aim present study was elucidate effect LPS on paracellular permeability known be severely affected IEC-18 cells were treated with effects morphology, their associated gene protein expressions...
Menopause and estrogen deficiency are associated with apparent intestinal resistance to vitamin D, which can be reversed by replacement. The in vivo influence of estrogens on duodenal D receptor (VDR) was studied three groups rats: ovariectomized (OVX), sham-operated, rats treated daily (40 microg/kg BW) for 2 weeks (OVX + E). Estrogen administration OVX resulted a 2-fold increase VDR messenger RNA transcripts. 1,25(OH)2D3 shown bind specifically one class receptors mucosal extracts,...
Leptin serum levels are about 5 times higher in obese people than normal individuals. We aimed at investigating the signaling pathways induced by leptin human colonic cell lines LS174T and HM7. Both cells expressed transmembrane Ob-receptor. activated mitogen-activated protein kinase pathway, invasion of concomitantly increased formation lamellipodial structures. A direct novel dose- time-dependent activation RhoA, Cdc42 Rac1 is demonstrated these aggressive colon cancer cells. The Rho...
Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering health and survival preterm infants. It well established that gut barrier severely damaged in NEC patients, nonetheless an depth investigation modifications at transcriptional translational levels tight junction genes proteins during are still missing. The aim this study was to investigate changes expression junctions other associated determine their correlation disease severity.We examined...
The present study was aimed at evaluating the effect of high intracolonic butyrate concentrations, either through fermentation a soluble fiber-enriched diet or via instillation, on colon cancer in chemically induced (dimethylhydrazine) rat model. effects were tested four groups dimethylhydrazine-treated rats: (i) rats fed standard diet, (ii) enriched with 15% citrus pectin, fiber that ferments and produces concentration butyrate, (iii) intrarectally instilled sodium solution (50 mM), (iv)...
Extracellular zinc promotes cell proliferation and its deficiency leads to impairment of this process, which is particularly important in epithelial cells. We have recently characterized a zinc-sensing receptor (ZnR) linking extracellular intracellular release calcium. In the present study, we addressed role zinc, acting via ZnR, regulating MAP kinase pathway Na+/H+ exchange colonocytes. demonstrate that Ca2+ release, mediated by induces phosphorylation ERK1/2, highly metal-specific,...
We previously demonstrated that 17beta-estradiol (E2) regulates the transcription and expression of vitamin D receptor (VDR) in rat colonocytes duodenocytes vivo. The aim present study was to assess whether extracellular signal-regulated kinase (ERK) induced by E2 is involved regulating VDR expression. compared E2-associated signaling activity HT29 colon cancer cells, a non-classical E2-target, with MCF-7 breast natural targets hormone. did not affect proliferation but enhanced cells....
Polysaccharides are one of the most potent mushroom-derived substances exhibiting anti-inflammatory and immunomodulatory properties. The aims present study were to determine whether orally administered glucans from edible mushroom Pleurotus pulmonarius could attenuate or prevent development experimental colitis in mice. Colonic inflammation was induced mice by treatment with 3·5 % dextran sulfate sodium (DSS) for 18 d. Before after DSS administration, given hot water solubles (HWS) mycelium...