A5082266686- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Free Radicals and Antioxidants
- Antimicrobial agents and applications
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Silicone and Siloxane Chemistry
- Advanced Polymer Synthesis and Characterization
- DNA and Nucleic Acid Chemistry
- Luminescence and Fluorescent Materials
- Machine Learning in Materials Science
- Antioxidant Activity and Oxidative Stress
- Photodynamic Therapy Research Studies
- Ferrocene Chemistry and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Coenzyme Q10 studies and effects
- Biochemical Acid Research Studies
University of Łódź
2016-2025
Medical University of Lodz
2024
General Directorate for Environmental Protection
2020
Leibniz Institute of Polymer Research
2015
Rzeszów University
2002
Lodz University of Technology
1998
Czech Academy of Sciences, Institute of Physics
1998
AbstractFour spectrophotometric methods of determination antioxidant capacity: a method based on the scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, ''ferric-reducing ability plasma'' (FRAP), reduction 2,2'-azinobis (3-ethylbenzthiazolinesulfonate) radical (ABTS ” + ) and kinetic oxidation dihydro-2,7- dichlorofluorescein by 2,2'-azobis (2-amidopropane) (ABAP) were compared with respect to standard antioxidants (ascorbate, glutathione, Trolox urate) human blood plasma....
The severe side effects of systemic chemotherapy for cervical cancer encourage the use topical intravaginal drug delivery systems. 5-fluorouracil, 5-FU, is an anticancer accepted in clinical therapy colorectal, gastric, and hepatocellular carcinoma. However, it shows low activity against cells (HeLa) thus requires usage additional drugs to support therapy, which associated with effects. We report on polyglycidol/polyacrylamide-based hydrogel carrier providing effective monotherapy cells,...
Abstract Dendrimers are highly branched macromolecules with the potential to be used for biomedical applications. Several dendrimers toxic owing their positively charged surfaces. However, this toxicity can reduced by coating these peripheral cationic groups carbohydrate residues. In study, of three types 4th generation poly (propyleneimine) were investigated in vivo ; uncoated (PPI‐g4) dendrimers, and which 25% or 100% surface amino coated maltotriose (PPI‐g4‐25%m PPI‐g4‐100%m),...
Conjugation of nanocarriers with antibodies that bind to specific membrane receptors are overexpressed in cancer cells enables targeted delivery. In the present study, we developed and synthesised two PAMAM dendrimer-trastuzumab conjugates carried docetaxel or paclitaxel, specifically which HER-2.The 1H NMR, 13C FTIR RP-HPLC were used analyse characteristics products assess their purity. The toxicity PAMAM-trastuzumab, PAMAM-doc-trastuzumab PAMAM-ptx-trastuzumab was determined using MTT...
In order to enhance intracellular uptake and accumulation of therapeutic nucleic acids for improved gene therapy methods, numerous delivery vectors have been elaborated. Based on their origin, carriers are generally classified as viral or non-viral vectors. Due significantly reduced immunogenicity highly optimized methods synthesis, nanoparticles (especially those imitating natural biomolecules) constitute a promising alternative virus-based devices. Thus, we set out develop innovative...
The disruption of the cellular pathways protein biosynthesis through mechanism RNA interference has been recognized as a tool great diagnostic and therapeutic significance. However, in order to fully exploit potential this phenomenon, efficient safe carriers capable overcoming extra- intracellular barriers delivering siRNA target cells are needed. Recently, attention focused on possibility application multifunctional nanoparticles, dendrimers, delivery devices for siRNA. aim present work was...
Characterization of dendrimers as potential therapeutics or drug carriers is complete only when toxicity assessed. There are numerous studies on the influence surface modification PAMAM and PPI their cytotoxic properties but without proposing a mechanism for toxic effect. In this study cytotoxicity profiles acid-terminated G3.5 amino-terminated G4 in comparison to unmodified PPI-G4 maltotriose modified were checked. Also cell death Chinese hamster ovary (CHO) human ovarian carcinoma (SKOV3)...
Prevention of amyloidosis by chemical compounds is a potential therapeutic strategy in Alzheimer's, prion and other neurodegenerative diseases. Regularly branched dendrimers less regular hyperbranched polymers have been suggested as promising inhibitors amyloid aggregation. As demonstrated our previous studies, some widely used (PAMAM, PPI) could not only inhibit aggregation solution but also dissolve mature fibrils. In this study we performed computer simulation polylysine 3rd 5th...
The strategy utilizing trastuzumab, a humanized monoclonal antibody against human epidermal growth receptor 2 (HER-2), as therapeutic agent in HER-2 positive breast cancer therapy seems to have advantage over traditional chemotherapy, especially when given combination with anticancer drugs. However, the effectiveness of single or conjugated chemotherapeutics is still far from ideal. Antibody⁻dendrimer conjugates hold potential improve targeting and release active substance at tumor site. In...
In order to overcome the obstacles and side effects of classical chemotherapy, numerous studies have been performed develop treatment based on targeted transport active compounds directly site action. Since tumor cells are featured with intensified glucose metabolism, we set out innovative, glucose-modified PAMAM dendrimer for delivery doxorubicin breast cancer cells.PAMAM-dox-glc conjugate was synthesized characterized by 1H NMR, FT-IR, size zeta potential measurements. The drug release...
Poly(propylene imine) dendrimers have been investigated for their biological applications but antibacterial activity has not extensively explored. Thus, the fourth generation of poly(propylene (PPI-G4) and PPI with a surface modified by attaching maltose in 25% 100% (PPI-25%mG4 PPI-100%mG4, respectively) was evaluated against Gram-positive bacteria: Staphylococcus aureus ATCC 6538, epidermidis 12228, Gram-negative Escherichia coli 25922, Pseudomonas aeruginosa 15442 yeast Candida albicans...
Oligosaccharide-modified poly(propylene imine) dendrimers are promising candidates as drug carriers and anti-prion agents. Here, we report the biodistribution of maltotriose-modified 4th generation (PPI) their ability to cross blood–brain–barrier that is important if these glycodendrimers considered potential therapeutic agents in central nervous system (CNS).
We have shown that clotrimazole formulations encapsulated in polyether-based unimolecular micelles significantly higher antitumour activity than the drug itself.
In the face of severe side effects systemic chemotherapy used in cervical cancer, topical selective drug carriers with long-lasting are being sought. Hydrogels suitable platforms, but their use is problematic case delivery hydrophobic drugs anticancer activity. Herein, hydrogels constructed unimolecular micelles displaying enhanced solubilization aromatic lipophilic bioactive compounds presented. Star-shaped poly(benzyl glycidyl ether)-block-poly(glycidyl glycerol ether) an aryl-enriched...
A simple spectrophotometric method of determination peroxyl radical-trapping capacity (PRTC) body fluids and food products is proposed. In this method, decomposition 2,2'-azobis(2-amidopropane) hydrochloride (ABAP) the source alkoxyl radicals which oxidize 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) to a green cation radical. Antioxidant present in sample inhibit reaction; induction time reaction proposed as parameter enabling antioxidant content. Standard assay conditions...
Glioblastoma (GBM) is the most frequent and aggressive primary tumor of brain averages a life expectancy in diagnosed patients only 15 months. Hence, more effective therapies against this malignancy are urgently needed. Several diseases, including cancer, featured by high levels reactive oxygen species (ROS), which possible GBM hallmarks to target or benefit from. Therefore, covalent linkage drugs ROS-responsive molecules can be exploited aiming for selective drug release within relevant...